Anesthesiology and Pain Medicine

Published by: Kowsar

The Contribution of NMDA Receptors in Antinociceptive Effect of Pregabalin: Comparison of Two Models of Pain Assessment

Manzumeh Shamsi Meymandi 1 , Fariborz Keyhanfar 2 , * , Gholam Reza Sepehri 1 , Gioia Heravi 1 and Omid Yazdanpanah 1
Authors Information
1 Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran
2 Pharmacology Department, Iran University of Medical Sciences, Tehran, Iran
Article information
  • Anesthesiology and Pain Medicine: June 2017, 7 (3); e14602
  • Published Online: June 21, 2017
  • Article Type: Research Article
  • Received: November 21, 2016
  • Revised: January 23, 2017
  • Accepted: March 8, 2017
  • DOI: 10.5812/aapm.14602

To Cite: Meymandi M S, Keyhanfar F, Sepehri G R, Heravi G, Yazdanpanah O. The Contribution of NMDA Receptors in Antinociceptive Effect of Pregabalin: Comparison of Two Models of Pain Assessment, Anesth Pain Med. 2017 ; 7(3):e14602. doi: 10.5812/aapm.14602.

Abstract
Copyright © 2017, Anesthesiology and Pain Medicine. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Acknowledgements
Footnote
References
  • 1. Woolf CJ, American College of P, American Physiological S. Pain: moving from symptom control toward mechanism-specific pharmacologic management. Ann Intern Med. 2004; 140(6): 441-51[PubMed]
  • 2. Gajraj NM. Pregabalin: its pharmacology and use in pain management. Anesth Analg. 2007; 105(6): 1805-15[DOI][PubMed]
  • 3. Moore RA, Straube S, Wiffen PJ, Derry S, McQuay HJ. Pregabalin for acute and chronic pain in adults. Cochrane Database Syst Rev. 2009; (3)[DOI][PubMed]
  • 4. Tuchman M, Barrett JA, Donevan S, Hedberg TG, Taylor CP. Central sensitization and Ca(V)alpha(2)delta ligands in chronic pain syndromes: pathologic processes and pharmacologic effect. J Pain. 2010; 11(12): 1241-9[DOI][PubMed]
  • 5. Gale JD, Houghton LA. Alpha 2 Delta (alpha(2)delta) Ligands, Gabapentin and Pregabalin: What is the Evidence for Potential Use of These Ligands in Irritable Bowel Syndrome. Front Pharmacol. 2011; 2: 28[DOI][PubMed]
  • 6. Blommel ML, Blommel AL. Pregabalin: an antiepileptic agent useful for neuropathic pain. Am J Health Syst Pharm. 2007; 64(14): 1475-82[DOI][PubMed]
  • 7. Joshi SS, Jagadeesh AM. Efficacy of perioperative pregabalin in acute and chronic post-operative pain after off-pump coronary artery bypass surgery: a randomized, double-blind placebo controlled trial. Ann Card Anaesth. 2013; 16(3): 180-5[DOI][PubMed]
  • 8. Imani F, Rahimzadeh P. Gabapentinoids: gabapentin and pregabalin for postoperative pain management. Anesth Pain Med. 2012; 2(2): 52-3[DOI][PubMed]
  • 9. Luszczki JJ. Dose-response relationship analysis of pregabalin doses and their antinociceptive effects in hot-plate test in mice. Pharmacol Rep. 2010; 62(5): 942-8[PubMed]
  • 10. Luszczki JJ, Florek-Luszczki M. Synergistic interaction of pregabalin with the synthetic cannabinoid WIN 55,212-2 mesylate in the hot-plate test in mice: an isobolographic analysis. Pharmacol Rep. 2012; 64(3): 723-32[PubMed]
  • 11. Meymandi MS, Keyhanfar F. Pregabalin antinociception and its interaction with tramadol in acute model of pain. Pharmacol Rep. 2012; 64(3): 576-85[PubMed]
  • 12. Ohashi-Doi K, Gale JD, Kurebayashi Y. Pregabalin inhibits accelerated defecation and decreased colonic nociceptive threshold in sensitized rats. Eur J Pharmacol. 2010; 643(1): 107-12[DOI][PubMed]
  • 13. Keyhanfar F, Shamsi Meymandi M, Sepehri G, Rastegaryanzadeh R, Heravi G. Evaluation of Antinociceptive Effect of Pregabalin in Mice and its Combination with Tramadol using Tail Flick Test. Iran J Pharm Res. 2013; 12(3): 483-93[PubMed]
  • 14. Shamsi Meymandi M, Keyhanfar F. Assessment of the antinociceptive effects of pregabalin alone or in combination with morphine during acetic acid-induced writhing in mice. Pharmacol Biochem Behav. 2013; 110: 249-54[DOI][PubMed]
  • 15. Sikandar S, Dickenson AH. Pregabalin modulation of spinal and brainstem visceral nociceptive processing. Pain. 2011; 152(10): 2312-22[DOI][PubMed]
  • 16. McRoberts JA, Ennes HS, Marvizon JC, Fanselow MS, Mayer EA, Vissel B. Selective knockdown of NMDA receptors in primary afferent neurons decreases pain during phase 2 of the formalin test. Neuroscience. 2011; 172: 474-82[DOI][PubMed]
  • 17. Willert RP, Woolf CJ, Hobson AR, Delaney C, Thompson DG, Aziz Q. The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-D-aspartate receptor. Gastroenterology. 2004; 126(3): 683-92[PubMed]
  • 18. Petrenko AB, Yamakura T, Baba H, Shimoji K. The role of N-methyl-D-aspartate (NMDA) receptors in pain: a review. Anesth Analg. 2003; 97(4): 1108-16[PubMed]
  • 19. Parsons CG. NMDA receptors as targets for drug action in neuropathic pain. Eur J Pharmacol. 2001; 429(1-3): 71-8[PubMed]
  • 20. Bennett GJ. Update on the neurophysiology of pain transmission and modulation: focus on the NMDA-receptor. J Pain Symptom Manage. 2000; 19(1 Suppl)-6[PubMed]
  • 21. Katzung BG. Basic and clinical pharmacology. 2007;
  • 22. Liu XJ, White TD, Sawynok J. Intraplantar injection of glutamate evokes peripheral adenosine release in the rat hind paw: involvement of peripheral ionotropic glutamate receptors and capsaicin-sensitive sensory afferents. J Neurochem. 2002; 80(4): 562-70[PubMed]
  • 23. Zhou Q, Nicholas Verne G. NMDA Receptors and Colitis: Basic Science and Clinical Implications. Rev Analg. 2008; 10(1): 33-43[PubMed]
  • 24. Shamsi Meymandi M, Keyhanfar F. Relative potency of pregabalin, gabapentin, and morphine in a mouse model of visceral pain. Can J Anaesth. 2013; 60(1): 44-9[DOI][PubMed]
  • 25. Le Bars D, Gozariu M, Cadden SW. Animal models of nociception. Pharmacol Rev. 2001; 53(4): 597-652[PubMed]
  • 26. Kumar N, Laferriere A, Yu JS, Leavitt A, Coderre TJ. Evidence that pregabalin reduces neuropathic pain by inhibiting the spinal release of glutamate. J Neurochem. 2010; 113(2): 552-61[DOI][PubMed]
  • 27. Rahimzadeh P. Gabapentinoids in pain setting. J Pain Relief. 2013; 2(2): 114
  • 28. Al-Amin HA, Saade NE, Khani M, Atweh S, Jaber M. Effects of chronic dizocilpine on acute pain and on mRNA expression of neuropeptides and the dopamine and glutamate receptors. Brain Res. 2003; 981(1-2): 99-107[PubMed]
  • 29. Nakama-Kitamura M. The N-Methyl-D-aspartate receptor antagonist dizocilpine inhibits associative antinociceptive tolerance to morphine in mice: relation with memory. J Pharmacol Sci. 2005; 97(1): 75-82[PubMed]
  • 30. Malec D, Poleszak E. Adenosine receptor ligands and dizocilpine-induced antinociception in mice. Int J Neurosci. 2005; 115(4): 511-22[DOI][PubMed]
  • 31. Gaudreau GA, Plourde V. Involvement of N-methyl-d-aspartate (NMDA) receptors in a rat model of visceral hypersensitivity. Behav Brain Res. 2004; 150(1-2): 185-9[DOI][PubMed]
  • 32. Ji Y, Traub RJ. Spinal NMDA receptors contribute to neuronal processing of acute noxious and nonnoxious colorectal stimulation in the rat. J Neurophysiol. 2001; 86(4): 1783-91[PubMed]
  • 33. Zhou S, Bonasera L, Carlton SM. Peripheral administration of NMDA, AMPA or KA results in pain behaviors in rats. Neuroreport. 1996; 7(4): 895-900[PubMed]
  • 34. Lawand NB, Willis WD, Westlund KN. Excitatory amino acid receptor involvement in peripheral nociceptive transmission in rats. Eur J Pharmacol. 1997; 324(2-3): 169-77[PubMed]
  • 35. Nemmani KV, Grisel JE, Stowe JR, Smith-Carliss R, Mogil JS. Modulation of morphine analgesia by site-specific N-methyl-D-aspartate receptor antagonists: dependence on sex, site of antagonism, morphine dose, and time. Pain. 2004; 109(3): 274-83[DOI][PubMed]
  • 36. Bryant CD, Eitan S, Sinchak K, Fanselow MS, Evans CJ. NMDA receptor antagonism disrupts the development of morphine analgesic tolerance in male, but not female C57BL/6J mice. Am J Physiol Regul Integr Comp Physiol. 2006; 291(2)-26[DOI][PubMed]
  • 37. Yoon MH, Bae HB, Choi JI. Antinociceptive interactions between intrathecal gabapentin and MK801 or NBQX in rat formalin test. J Korean Med Sci. 2005; 20(2): 307-12[DOI][PubMed]
  • 38. Berrino L, Oliva P, Massimo F, Aurilio C, Maione S, Grella A, et al. Antinociceptive effect in mice of intraperitoneal N-methyl-D-aspartate receptor antagonists in the formalin test. Eur J Pain. 2003; 7(2): 131-7[DOI][PubMed]
  • 39. Sabetkasaie M, Khansefid N, Ladgevardi MA. Possible role of NMDA receptors in antinociception induced by rilmenidine in mice in the formalin test. Eur J Pain. 2007; 11(5): 535-41[DOI][PubMed]
  • 40. McRoberts JA, Coutinho SV, Marvizon JC, Grady EF, Tognetto M, Sengupta JN, et al. Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats. Gastroenterology. 2001; 120(7): 1737-48[PubMed]
  • 41. Zhou Q, Price DD, Caudle RM, Verne GN. Spinal NMDA NR1 subunit expression following transient TNBS colitis. Brain Res. 2009; 1279: 109-20[DOI][PubMed]
  • 42. Tsukamoto M, Kiso T, Shimoshige Y, Aoki T, Matsuoka N. Spinal mechanism of standard analgesics: evaluation using mouse models of allodynia. Eur J Pharmacol. 2010; 634(1-3): 40-5[DOI][PubMed]
  • 43. Quintero JE, Dooley DJ, Pomerleau F, Huettl P, Gerhardt GA. Amperometric measurement of glutamate release modulation by gabapentin and pregabalin in rat neocortical slices: role of voltage-sensitive Ca2+ alpha2delta-1 subunit. J Pharmacol Exp Ther. 2011; 338(1): 240-5[DOI][PubMed]
  • 44. Singh NS, Paul RK, Torjman MC, Wainer IW. Gabapentin and (S)-pregabalin decrease intracellular D-serine concentrations in PC-12 cells. Neurosci Lett. 2013; 535: 90-4[DOI][PubMed]
  • 45. Micheva KD, Taylor CP, Smith SJ. Pregabalin reduces the release of synaptic vesicles from cultured hippocampal neurons. Mol Pharmacol. 2006; 70(2): 467-76[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments