Anesthesiology and Pain Medicine

Published by: Kowsar

Evolution and Mode of Action of Pulsed Radiofrequency

Menno E. Sluijter 1 , * and Farnad Imani 2
Authors Information
1 Department of Pain Medicine, Swiss Paraplegic Center, Nottwil, Switzerland
2 Department of Anesthesiology and Pain Medicine, Rasoul Akram Medical Center, Iran University of Medical Sciences (IUMS), Tehran, IR Iran
Article information
  • Anesthesiology and Pain Medicine: April 6, 2013, 2 (4); 139-41
  • Published Online: March 26, 2013
  • Article Type: Editorial
  • Received: January 4, 2013
  • Accepted: January 14, 2013
  • DOI: 10.5812/aapm.10213

To Cite: E. Sluijter M, Imani F. Evolution and Mode of Action of Pulsed Radiofrequency, Anesth Pain Med. 2013 ; 2(4):139-41. doi: 10.5812/aapm.10213.

Copyright © 2013, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
  • 1. Sluijter ME, Teixeira A, Serra V, Balogh S, Schianchi P. Intra-articular application of pulsed radiofrequency for arthrogenic pain--report of six cases. Pain Pract. 2008; 8(1): 57-61[DOI][PubMed]
  • 2. Schianchi PM, Sluijter ME, Balogh SE. The Treatment of Joint Pain with Intra-articular Pulsed Radiofrequency. Anesth Pain. 2013;
  • 3. Teixeira A, Sluijter ME. Intravenous application of pulsed radiofrequency- 4 case reports. Anesth Pain. 2013;
  • 4. Maier SF, Watkins LR. Cytokines for psychologists: implications of bidirectional immune-to-brain communication for understanding behavior, mood, and cognition. Psychol Rev. 1998; 105(1): 83-107[PubMed]
  • 5. McEwen BS. Stress, adaptation, and disease. Allostasis and allostatic load. Ann N Y Acad Sci. 1998; 840: 33-44[PubMed]
  • 6. Higuchi Y, Nashold BS, Jr., Sluijter M, Cosman E, Pearlstein RD. Exposure of the dorsal root ganglion in rats to pulsed radiofrequency currents activates dorsal horn lamina I and II neurons. Neurosurgery. 2002; 50(4): 850-5[PubMed]
  • 7. Erdine S, Bilir A, Cosman ER, Cosman ER, Jr. Ultrastructural changes in axons following exposure to pulsed radiofrequency fields. Pain Pract. 2009; 9(6): 407-17[DOI][PubMed]
  • 8. Erdine S, Yucel A, Cimen A, Aydin S, Sav A, Bilir A. Effects of pulsed versus conventional radiofrequency current on rabbit dorsal root ganglion morphology. Eur J Pain. 2005; 9(3): 251-6[DOI][PubMed]
  • 9. Imani F, Gharaei H, Rezvani M. Pulsed Radiofrequency of Lumbar Dorsal Root Ganglion for Chronic Postamputation Phantom Pain. Anesth Pain. 2012; 1(3): 194-7
  • 10. Hai Liang Chua N, Halim W, Beems T, Vissers KCP. Pulsed Radiofrequency Treatment for Trigeminal Neuralgia. Anesth Pain. 2012; 1(4): 257-61[DOI]
  • 11. Cosman ER, Jr., Cosman ER, Sr. Electric and thermal field effects in tissue around radiofrequency electrodes. Pain Med. 2005; 6(6): 405-24[DOI][PubMed]
  • 12. Imani F. Using Pulsed Radiofrequency for Chronic Pain. Anesth Pain. 2012; 1(3): 155-6[DOI]
  • 13. Cahana A, Vutskits L, Muller D. Acute differential modulation of synaptic transmission and cell survival during exposure to pulsed and continuous radiofrequency energy. J Pain. 2003; 4(4): 197-202[PubMed]
  • 14. Taverner MG, Ward TL, Loughnan TE. Transcutaneous pulsed radiofrequency treatment in patients with painful knee awaiting total knee joint replacement. Clin J Pain. 2010; 26(5): 429-32[DOI][PubMed]
  • 15. Van Duijn B. Exploration of anti-inflammatory effect of PRF at the cellular level.
  • 16. Czura CJ, Tracey KJ. Autonomic neural regulation of immunity. J Intern Med. 2005; 257(2): 156-66[DOI][PubMed]
  • 17. Hagiwara S, Iwasaka H, Takeshima N, Noguchi T. Mechanisms of analgesic action of pulsed radiofrequency on adjuvant-induced pain in the rat: roles of descending adrenergic and serotonergic systems. Eur J Pain. 2009; 13(3): 249-52[DOI][PubMed]
  • 18. Callard R, George AJ, Stark J. Cytokines, chaos, and complexity. Immunity. 1999; 11(5): 507-13[PubMed]
  • 19. Meisel C, Meisel A. Suppressing immunosuppression after stroke. N Engl J Med. 2011; 365(22): 2134-6[DOI][PubMed]
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