Anesthesiology and Pain Medicine

Published by: Kowsar

Magnesium Can Decrease Postoperative Physiological Ileus and Postoperative Pain in Major non Laparoscopic Gastrointestinal Surgeries: A Randomized Controlled Trial

Reza Shariat Moharari 1 , Majid Motalebi 1 , Atabak Najafi 1 , Mohammad Mahdi Zamani 2 , Farsad Imani 1 , Farhad Etezadi 1 , Pejman Pourfakhr 1 and Mohammad Reza Khajavi 1 , *
Authors Information
1 Department of Anesthesiology and Critical Care, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Anesthesiology and Critical Care, Iran University of Medical Sciences, Tehran, Iran
Article information
  • Anesthesiology and Pain Medicine: February 01, 2014, 4 (1); e12750
  • Published Online: December 6, 2013
  • Article Type: Research Article
  • Received: June 25, 2013
  • Revised: August 25, 2013
  • Accepted: August 29, 2013
  • DOI: 10.5812/aapm.12750

To Cite: Shariat Moharari R, Motalebi M, Najafi A, Zamani M M, Imani F, et al. Magnesium Can Decrease Postoperative Physiological Ileus and Postoperative Pain in Major non Laparoscopic Gastrointestinal Surgeries: A Randomized Controlled Trial, Anesth Pain Med. 2014 ; 4(1):e12750. doi: 10.5812/aapm.12750.

Copyright © 2013, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Iseri LT, French JH. Magnesium: nature's physiologic calcium blocker. Am heart J. 1984; 108(1): 188-93
  • 2. Koinig H, Wallner T, Marhofer P, Andel H, Horauf K, Mayer N. Magnesium sulfate reduces intra- and postoperative analgesic requirements. Anesth Analg. 1998; 87(1): 206-10[PubMed]
  • 3. Dube L, Granry JC. The therapeutic use of magnesium in anesthesiology, intensive care and emergency medicine: a review. Can J Anaesth. 2003; 50(7): 732-46[DOI][PubMed]
  • 4. Wong CH, Dey P, Yarmush J, Wu WH, Zbuzek VK. Nifedipine-induced analgesia after epidural injection in rats. Anesth Analg. 1994; 79(2): 303-6[PubMed]
  • 5. Santillan R, Maestre JM, Hurle MA, Florez J. Enhancement of opiate analgesia by nimodipine in cancer patients chronically treated with morphine: a preliminary report. Pain. 1994; 58(1): 129-32[PubMed]
  • 6. Coderre TJ, Katz J, Vaccarino AL, Melzack R. Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain. 1993; 52(3): 259-85[PubMed]
  • 7. Woolf CJ, Thompson SW. The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states. Pain. 1991; 44(3): 293-9[PubMed]
  • 8. Thompson SW, Moscicki JC, DiFazio CA. The anesthetic contribution of magnesium sulfate and ritodrine hydrochloride in rats. Anesth Analg. 1988; 67(1): 31-4[PubMed]
  • 9. Telci L, Esen F, Akcora D, Erden T, Canbolat AT, Akpir K. Evaluation of effects of magnesium sulphate in reducing intraoperative anaesthetic requirements. Br J Anaesth. 2002; 89(4): 594-8[PubMed]
  • 10. Tramer MR, Schneider J, Marti RA, Rifat K. Role of magnesium sulfate in postoperative analgesia. Anesthesiology. 1996; 84(2): 340-7[PubMed]
  • 11. Shoar S, Esmaeili S, Safari S. Pain Management After Surgery: A Brief Review. Anesth Pain . 2012; 1(3): 184-186
  • 12. Levaux Ch, Bonhomme V, Dewandre PY, Brichant JF, Hans P. Effect of intra-operative magnesium sulphate on pain relief and patient comfort after major lumbar orthopaedic surgery. Anaesthesia. 2003; 58(2): 131-5[PubMed]
  • 13. Imani F, Najafi A, Hossein Sadr-al-sadat S, Khajavi MR, Moharrari RS, Azimi K. [Evaluation of analgesic effect of Magne-sium sulfate in postoperative pain in lumbar spine surgery]. J Iran Society Anasthesiol Intensive Care. 2006; 53(1): 36-41
  • 14. Morimoto H, Cullen JJ, Messick JRJM, Kelly KA. Epidural analgesia shortens postoperative ileus after ileal pouch-anal canal anastomosis. Am J Surg. 1995; 169(1): 79
  • 15. Albrecht E, Kirkham KR, Liu SS, Brull R. Peri-operative intravenous administration of magnesium sulphate and postoperative pain: a meta-analysis. Anaesthesia. 2013; 68(1): 79-90[DOI][PubMed]
  • 16. Ghodraty MR, Saif AA, Kholdebarin AR, Rokhtabnak F, Pournajafian AR, Nikzad-Jamnani AR, et al. The effects of magnesium sulfate on neuromuscular blockade by cisatracurium during induction of anesthesia. J Anesth. 2012; 26(6): 858-63[DOI][PubMed]
  • 17. Seyhan TO, Tugrul M, Sungur MO, Kayacan S, Telci L, Pembeci K, et al. Effects of three different dose regimens of magnesium on propofol requirements, haemodynamic variables and postoperative pain relief in gynaecological surgery. Br J Anaesth. 2006; 96(2): 247-52[DOI][PubMed]
  • 18. Sanchez-Capuchino A, McConachie I. Peri-operative effect of major gastrointestinal surgery on serum magnesium. Anaesthesia. 1994; 49(10): 912-4[PubMed]
  • 19. Nimmo WS, Heading RC, Wilson J, Tothill P, Prescott LF. Inhibition of gastric emptying and drug absorption by narcotic analgesics. Br J Clin Pharmacol. 1975; 2(6): 509-13[PubMed]
  • 20. Fotiadis RJ, Badvie S, Weston MD, Allen-Mersh TG. Epidural analgesia in gastrointestinal surgery. Br J Surg. 2004; 91(7): 828-41[DOI][PubMed]
  • 21. Yousef AA, Al-deeb AE. A double-blinded randomised controlled study of the value of sequential intravenous and oral magnesium therapy in patients with chronic low back pain with a neuropathic component. Anaesthesia. 2013; 68(3): 260-6[DOI][PubMed]
  • 22. Fawcett WJ, Haxby EJ, Male DA. Magnesium: physiology and pharmacology. Br J Anaesth. 1999; 83(2): 302-20[PubMed]
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