Anesthesiology and Pain Medicine

Published by: Kowsar

Analgesic Effects of Paracetamol and Morphine After Elective Laparotomy Surgeries

Mahzad Alimian 1 , Alireza Pournajafian 2 , * , Alireza Kholdebarin 2 , Mohammadreza Ghodraty 2 , Faranak Rokhtabnak 2 and Payman Yazdkhasti 2
Authors Information
1 Department of Anesthesiology, Rasool Akram Medical Center, Iran University of Medical Sciences, Tehran, Iran
2 Department of Anesthesiology and pain, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran
Article information
  • Anesthesiology and Pain Medicine: May 01, 2014, 4 (2); e12912
  • Published Online: March 8, 2014
  • Article Type: Research Article
  • Received: June 13, 2013
  • Revised: August 3, 2013
  • Accepted: August 10, 2013
  • DOI: 10.5812/aapm.12912

To Cite: Alimian M, Pournajafian A, Kholdebarin A, Ghodraty M, Rokhtabnak F, et al. Analgesic Effects of Paracetamol and Morphine After Elective Laparotomy Surgeries, Anesth Pain Med. 2014 ; 4(2):e12912. doi: 10.5812/aapm.12912.

Copyright © 2014, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Imani F. Postoperative pain management. Anesth Pain Med. 2011; 1(1): 6-7[DOI]
  • 2. Van Aken H, Thys L, Veekman L, Buerkle H. Assessing analgesia in single and repeated administrations of propacetamol for postoperative pain: comparison with morphine after dental surgery. Anesth Analg. 2004; 98(1): 159-65[PubMed]
  • 3. Ong CKS, Seymour RA, Lirk P, Merry AF. Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain. Anesth Analg. 2010; 110(4): 1170-9
  • 4. Hurley RW, Wu CL. Acute postoperative pain. Ronald D. miller, Anesthesia. 7th edition, Philadelphia, Churchil Livingstone. 2010; : 2758-9
  • 5. Imani F, Safari S. “Pain Relief is an Essential Human Right”, We Should be Concerned about It. Anesth Pain Med. 2011; 1(2): 55-7[DOI]
  • 6. Moller PL, Juhl GI, Payen-Champenois C, Skoglund LA. Intravenous acetaminophen (paracetamol): comparable analgesic efficacy, but better local safety than its prodrug, propacetamol, for postoperative pain after third molar surgery. Anesth Analg. 2005; 101(1): 90-6[DOI][PubMed]
  • 7. Graham GG, Scott KF. Mechanism of action of paracetamol. Am J Ther. 2005; 12(1): 46-55[PubMed]
  • 8. Moffat AC, Kenny GN, Prentice JW. Postoperative nefopam and diclofenac. Evaluation of their morphine-sparing effect after upper abdominal surgery. Anaesthesia. 1990; 45(4): 302-5[PubMed]
  • 9. Cataldo PA, Senagore AJ, Kilbride MJ. Ketorolac and patient controlled analgesia in the treatment of postoperative pain. Surg Gynecol Obstet. 1993; 176(5): 435-8[PubMed]
  • 10. Hernandez-Palazon J, Tortosa JA, Martinez-Lage JF, Perez-Flores D. Intravenous administration of propacetamol reduces morphine consumption after spinal fusion surgery. Anesth Analg. 2001; 92(6): 1473-6[PubMed]
  • 11. Etches RC, Warriner CB, Badner N, Buckley DN, Beattie WS, Chan VW, et al. Continuous intravenous administration of ketorolac reduces pain and morphine consumption after total hip or knee arthroplasty. Anesth Analg. 1995; 81(6): 1175-80[PubMed]
  • 12. Parker RK, Holtmann B, Smith I, White PF. Use of ketorolac after lower abdominal surgery. Effect on analgesic requirement and surgical outcome. Anesthesiology. 1994; 80(1): 6-12[PubMed]
  • 13. Ang ET, Goldfarb G, Boccard E. Analgesic efficacy of propacetamol hydrochlorate 2 g versus pentazocine 30 mg after orthopedic surgery. Eur J Pain. 1990; 11: 137-42
  • 14. Farkas JC, Larrouturou P, Morin JP. Analgesic efficacy of an injectable Acetaminophen versus a dipyrone plus pitofenona plus fenpiverinium association After abdominal aortic repair. Curr Ther Res. 1992; 51: 19 –27
  • 15. Sevarino FB, Sinatra RS, Paige D, Silverman DG. Intravenous ketorolac as an adjunct to patient-controlled analgesia (PCA) for management of postgynecologic surgical pain. J Clin Anesth. 1994; 6(1): 23-7[PubMed]
  • 16. Schug SA, Sidebotham DA, McGuinnety M, Thomas J, Fox L. Acetaminophen as an adjunct to morphine by patient-controlled analgesia in the management of acute postoperative pain. Anesth Analg. 1998; 87(2): 368-72[PubMed]
  • 17. Hynes D, McCarroll M, Hiesse-Provost O. Analgesic efficacy of parenteral paracetamol (propacetamol) and diclofenac in post-operative orthopaedic pain. Acta Anaesthesiol Scand. 2006; 50(3): 374-81[DOI][PubMed]
  • 18. Gousheh SM, Nesioonpour S, Javaher Foroosh F, Akhondzadeh R, Sahafi SA, Alizadeh Z. Intravenous paracetamol for postoperative analgesia in laparoscopic cholecystectomy. Anesth Pain Med. 2013; 3(1): 214-8[DOI][PubMed]
  • 19. Mathiesen O, Rasmussen ML, Dierking G, Lech K, Hilsted KL, Fomsgaard JS, et al. Pregabalin and dexamethasone in combination with paracetamol for postoperative pain control after abdominal hysterectomy. A randomized clinical trial. Acta Anaesthesiol Scand. 2009; 53(2): 227-35[DOI][PubMed]
  • 20. Schmidt A, Bjorkman S, Akeson J. Preoperative rectal diclofenac versus paracetamol for tonsillectomy: effects on pain and blood loss. Acta Anaesthesiol Scand. 2001; 45(1): 48-52[PubMed]
  • 21. Borisov DB, Levin AV, Vyl'iurov IV, Sokolov AV, Nedashkovskii EV. [Efficiency of preemptive intravenous paracetamol analgesia in abdominal surgery]. Anesteziol Reanimatol. 2007; (5): 38-40[PubMed]
  • 22. Morgan S. Intravenous paracetamol in patients with renal colic. Emerg Nurse. 2011; 18(9): 22-5[DOI][PubMed]
  • 23. Imani F, Rahimzadeh P, Hamid Reza Faiz S. Comparison of the efficacy of adding clonidine, chlorpromazine, promethazine, and midazolam to morphine pumps in postoperative pain control of addicted patients. Anesth Pain Med. 2011; 1(1): 10-4[DOI]
  • 24. Moradi M, Esmaeili S, Shoar S, Safari S. Use of Oxycodone in Pain Management. Anesth Pain Med. 2012; 1(4): 262-4[DOI]
  • 25. Imani F, Rahimzadeh P. Gabapentinoids: gabapentin and pregabalin for postoperative pain management. Anesth Pain Med. 2012; 2(2): 52-3[DOI][PubMed]
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