Anesthesiology and Pain Medicine

Published by: Kowsar

Attenuation of Cisplathin-Induced Toxic Oxidative Stress by Propofol

Ghazaleh Taheri Moghadam 1 , Seyed-Mostafa ‎Hosseini-Zijoud 2 , Tavakol Heidary Shayesteh 3 , Hassan Ghasemi 1 and Akram Ranjbar 3 , *
Authors Information
1 Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran
2 Clinical Research Development Unit, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan ‎University of Medical Sciences, Hamadan, Iran
Article information
  • Anesthesiology and Pain Medicine: October 01, 2014, 4 (4); e14221
  • Published Online: September 9, 2014
  • Article Type: Research Article
  • Received: August 14, 2013
  • Revised: April 7, 2014
  • Accepted: April 23, 2014
  • DOI: 10.5812/aapm.14221

To Cite: Taheri Moghadam G, ‎Hosseini-Zijoud S, Heidary Shayesteh T, Ghasemi H, Ranjbar A. Attenuation of Cisplathin-Induced Toxic Oxidative Stress by Propofol, Anesth Pain Med. 2014 ; 4(4):e14221. doi: 10.5812/aapm.14221.

Copyright © 2014, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Boulikas T, Vougiouka M. Cisplatin and platinum drugs at the molecular level. (Review). Oncol Rep. 2003; 10(6): 1663-82[PubMed]
  • 2. Yao X, Panichpisal K, Kurtzman N, Nugent K. Cisplatin nephrotoxicity: a review. Am J Med Sci. 2007; 334(2): 115-24[DOI][PubMed]
  • 3. Rybak LP, Mukherjea D, Jajoo S, Ramkumar V. Cisplatin ototoxicity and protection: clinical and experimental studies. Tohoku J Exp Med. 2009; 219(3): 177-86[PubMed]
  • 4. Ravi R, Somani SM, Rybak LP. Mechanism of cisplatin ototoxicity: antioxidant system. Pharmacol Toxicol. 1995; 76(6): 386-94[PubMed]
  • 5. Arjumand W, Seth A, Sultana S. Rutin attenuates cisplatin induced renal inflammation and apoptosis by reducing NFkappaB, TNF-alpha and caspase-3 expression in wistar rats. Food Chem Toxicol. 2011; 49(9): 2013-21[DOI][PubMed]
  • 6. Antunes LM, Darin JD, Bianchi MD. Protective effects of vitamin c against cisplatin-induced nephrotoxicity and lipid peroxidation in adult rats: a dose-dependent study. Pharmacol Res. 2000; 41(4): 405-11[DOI][PubMed]
  • 7. Marik PE. Propofol: An Immunomodulating Agent. Pharmacy. 2005; 25(5 Part 2): 28S-33S[DOI]
  • 8. Ansley DM, Lee J, Godin DV, Garnett ME, Qayumi AK. Propofol enhances red cell antioxidant capacity in swine and humans. Can J Anaesth. 1998; 45(3): 233-9[PubMed]
  • 9. Tesauro M, Thompson WC, Moss J. Effect of staurosporine-induced apoptosis on endothelial nitric oxide synthase in transfected COS-7 cells and primary endothelial cells. Cell Death Differ. 2006; 13(4): 597-606[DOI][PubMed]
  • 10. Xu JJ, Wang YL. Propofol attenuation of hydrogen peroxide-mediated oxidative stress and apoptosis in cultured cardiomyocytes involves haeme oxygenase-1. Eur J Anaesthesiol. 2008; 25(5): 395-402[DOI][PubMed]
  • 11. Kobayashi K, Yoshino F, Takahashi SS, Todoki K, Maehata Y, Komatsu T, et al. Direct assessments of the antioxidant effects of propofol medium chain triglyceride/long chain triglyceride on the brain of stroke-prone spontaneously hypertensive rats using electron spin resonance spectroscopy. Anesthesiology. 2008; 109(3): 426-35[DOI][PubMed]
  • 12. Chen J, Gu Y, Shao Z, Luo J, Tan Z. Propofol protects against hydrogen peroxide-induced oxidative stress and cell dysfunction in human umbilical vein endothelial cells. Mol Cell Biochem. 2010; 339(1-2): 43-54[DOI][PubMed]
  • 13. Ulu R, Dogukan A, Tuzcu M, Gencoglu H, Ulas M, Ilhan N, et al. Regulation of renal organic anion and cation transporters by thymoquinone in cisplatin induced kidney injury. Food Chem Toxicol. 2012; 50(5): 1675-9[DOI][PubMed]
  • 14. Chirino YI, Pedraza-Chaverri J. Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity. Exp Toxicol Pathol. 2009; 61(3): 223-42[DOI][PubMed]
  • 15. Ozturk E, Demirbilek S, Koroglu A, But A, Begec ZO, Gulec M, et al. Propofol and erythropoietin antioxidant properties in rat brain injured tissue. Prog Neuropsychopharmacol Biol Psychiatry. 2008; 32(1): 81-6[DOI][PubMed]
  • 16. Ranjbar A, Ghahremani MH, Sharifzadeh M, Golestani A, Ghazi-Khansari M, Baeeri M, et al. Protection by pentoxifylline of malathion-induced toxic stress and mitochondrial damage in rat brain. Hum Exp Toxicol. 2010; 29(10): 851-64[DOI][PubMed]
  • 17. Abdollahi M, Ranjbar A, Shadnia S, Nikfar S, Rezaie A. Pesticides and oxidative stress: a review. Med Sci Monit. 2004; 10(6)-7[PubMed]
  • 18. Moore K, Roberts LJ. Measurement of Lipid Peroxidation. Free Radical Res. 1998; 28(6): 659-71[DOI]
  • 19. Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem. 1996; 239(1): 70-6[DOI][PubMed]
  • 20. Hu M, Dillard C. Plasma SH and GSH measurement. Methods Enzymol. 1994; 233(385): 87
  • 21. Bayona NA, Gelb AW, Jiang Z, Wilson JX, Urquhart BL, Cechetto DF. Propofol neuroprotection in cerebral ischemia and its effects on low-molecular-weight antioxidants and skilled motor tasks. Anesthesiology. 2004; 100(5): 1151-9[PubMed]
  • 22. Abderrezak A, Bourassa P, Mandeville JS, Sedaghat-Herati R, Tajmir-Riahi HA. Dendrimers bind antioxidant polyphenols and cisplatin drug. PLoS One. 2012; 7(3)[DOI][PubMed]
  • 23. Naziroglu M, Karaoglu A, Aksoy AO. Selenium and high dose vitamin E administration protects cisplatin-induced oxidative damage to renal, liver and lens tissues in rats. Toxicology. 2004; 195(2-3): 221-30[PubMed]
  • 24. Kahraman S, Kilinc K, Dal D, Erdem K. Propofol attenuates formation of lipid peroxides in tourniquet-induced ischaemia-reperfusion injury. Br J Anaesth. 1997; 78(3): 279-81[PubMed]
  • 25. Goode HF, Cowley HC, Walker BE, Howdle PD, Webster NR. Decreased antioxidant status and increased lipid peroxidation in patients with septic shock and secondary organ dysfunction. Crit Care Med. 1995; 23(4): 646-51[PubMed]
  • 26. Eriksson O. Effects of the general anaesthetic Propofol on the Ca2+-induced permeabilization of rat liver mitochondria. FEBS Letters. 1991; 279(1): 45-8[DOI]
  • 27. Dogukan A, Tuzcu M, Agca CA, Gencoglu H, Sahin N, Onderci M, et al. A tomato lycopene complex protects the kidney from cisplatin-induced injury via affecting oxidative stress as well as Bax, Bcl-2, and HSPs expression. Nutr Cancer. 2011; 63(3): 427-34[DOI][PubMed]
  • 28. Kruidering M, Van de Water B, de Heer E, Mulder GJ, Nagelkerke JF. Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain. J Pharmacol Exp Ther. 1997; 280(2): 638-49[PubMed]
  • 29. Yousef MI, Saad AA, El-Shennawy LK. Protective effect of grape seed proanthocyanidin extract against oxidative stress induced by cisplatin in rats. Food Chem Toxicol. 2009; 47(6): 1176-83[DOI][PubMed]
  • 30. Silici S, Ekmekcioglu O, Kanbur M, Deniz K. The protective effect of royal jelly against cisplatin-induced renal oxidative stress in rats. World J Urol. 2011; 29(1): 127-32[DOI][PubMed]
  • 31. Branca D, Roberti MS, Lorenzin P, Vincenti E, Scutari G. Influence of the anesthetic 2,6-diisopropylphenol on the oxidative phosphorylation of isolated rat liver mitochondria. Biochem Pharmacy. 1991; 42(1): 87-90[DOI]
  • 32. Tsujimoto Y, Shimizu S. Role of the mitochondrial membrane permeability transition in cell death. Apoptosis. 2007; 12(5): 835-40[DOI][PubMed]
  • 33. Javadov S. Protection of hearts from reperfusion injury by propofol is associated with inhibition of the mitochondrial permeability transition. Cardiovasc Res. 2000; 45(2): 360-9[DOI]
  • 34. Crompton M. The mitochondrial permeability transition pore and its role in cell death. Biochem J. 1999; 341 ( Pt 2): 233-49[PubMed]
  • 35. Szymonik-Lesiuk S, Czechowska G, Stryjecka-Zimmer M, Slomka M, Madro A, Celinski K, et al. Catalase, superoxide dismutase, and glutathione peroxidase activities in various rat tissues after carbon tetrachloride intoxication. J Hepatobiliary Pancreat Surg. 2003; 10(4): 309-15[DOI][PubMed]
  • 36. Pace A, Giannarelli D, Galie E, Savarese A, Carpano S, Della Giulia M, et al. Vitamin E neuroprotection for cisplatin neuropathy: a randomized, placebo-controlled trial. Neurology. 2010; 74(9): 762-6[DOI][PubMed]
  • 37. Mise T, Yasumoto T. Simultaneous Treatment of Cancer Cells Lines with the Anticancer Drug Cisplatin and the Antioxidant Fucoxanthin. Br Pharmacol J. 2011;
  • 38. Durak I, Ozbek H, Karaayvaz M, Ozturk HS. Cisplatin induces acute renal failure by impairing antioxidant system in guinea pigs: effects of antioxidant supplementation on the cisplatin nephrotoxicity. Drug Chem Toxicol. 2002; 25(1): 1-8[DOI][PubMed]
  • 39. Kim HS, Chang WC, Hwang KC, Choi IG, Park WK. Effect of propofol on calcium homeostasis in hypoxia-reoxygenated neonatal rat cardiomyocytes. Eur J Pharmacol. 2008; 594(1-3): 139-45[DOI][PubMed]
  • 40. Noh HS, Shin IW, Ha JH, Hah YS, Baek SM, Kim DR. Propofol protects the autophagic cell death induced by the ischemia/reperfusion injury in rats. Mol Cells. 2010; 30(5): 455-60[DOI][PubMed]
  • 41. Ko SH, Yu C, Lee SK, Choe H, Chung MJ, Kwak YG, et al. Propofol Attenuates Ischemia-Reperfusion Injury in the Isolated Rat Heart. Anesth Analg. 1997; 85(4): 719-24[DOI]
  • 42. Xia WF, Liu Y, Zhou QS, Tang QZ, Zou HD. Comparison of the effects of propofol and midazolam on inflammation and oxidase stress in children with congenital heart disease undergoing cardiac surgery. Yonsei Med J. 2011; 52(2): 326-32[DOI][PubMed]
  • 43. Lai HC, Yeh YC, Wang LC, Ting CT, Lee WL, Lee HW, et al. Propofol ameliorates doxorubicin-induced oxidative stress and cellular apoptosis in rat cardiomyocytes. Toxicol Appl Pharmacol. 2011; 257(3): 437-48[DOI][PubMed]
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