Anesthesiology and Pain Medicine

Published by: Kowsar

The Effect of Intravenous Magnesium Sulfate and Lidocaine in Hemodynamic Responses to Endotracheal Intubation in Elective Coronary Artery Bypass Grafting: A Randomized Controlled Clinical Trial

Mehrdad Mesbah Kiaee 1 , Saeid Safari 1 , Gholam Reza Movaseghi 1 , Mahmoud Reza Mohaghegh Dolatabadi 1 , Masoud Ghorbanlo 1 , Mehrnoosh Etemadi 2 , Seyed Arash Amiri 1 and Mohammad Mahdi Zamani 1 , 2 , *
Authors Information
1 Department of Anesthesiology and Pain Medicine, Iran University of Medical Sciences, Tehran, Iran
2 Students' Scientific Research Centre, Tehran University of Medical Sciences, Tehran, Iran
Article information
  • Anesthesiology and Pain Medicine: August 01, 2014, 4 (3); e15905
  • Published Online: June 21, 2014
  • Article Type: Research Article
  • Received: November 1, 2013
  • Revised: December 21, 2013
  • Accepted: January 8, 2014
  • DOI: 10.5812/aapm.15905

To Cite: Mesbah Kiaee M, Safari S, Movaseghi G R, Mohaghegh Dolatabadi M R, Ghorbanlo M, et al. The Effect of Intravenous Magnesium Sulfate and Lidocaine in Hemodynamic Responses to Endotracheal Intubation in Elective Coronary Artery Bypass Grafting: A Randomized Controlled Clinical Trial, Anesth Pain Med. 2014 ; 4(3):e15905. doi: 10.5812/aapm.15905.

Copyright © 2014, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Montes FR, Giraldo JC, Betancur LA, Rincon JD, Rincon IE, Vanegas MV, et al. Endotracheal intubation with a lightwand or a laryngoscope results in similar hemodynamic variations in patients with coronary artery disease. Can J Anaesth. 2003; 50(8): 824-8[PubMed]
  • 2. Puri GD, Marudhachalam KS, Chari P, Suri RK. The effect of magnesium sulphate on hemodynamics and its efficacy in attenuating the response to endotracheal intubation in patients with coronary artery disease. Anesth Analg. 1998; 87(4): 808-11[PubMed]
  • 3. Dube L, Granry JC. The therapeutic use of magnesium in anesthesiology, intensive care and emergency medicine: a review. Can J Anaesth. 2003; 50(7): 732-46[DOI][PubMed]
  • 4. Khalili G, Janghorbani M, Sajedi P, Ahmadi G. Effects of adjunct intrathecal magnesium sulfate to bupivacaine for spinal anesthesia: a randomized, double-blind trial in patients undergoing lower extremity surgery. J Anesth. 2011; 25(6): 892-7[DOI][PubMed]
  • 5. Mayer ML, Westbrook GL, Guthrie PB. Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones. Nature. 1984; 309(5965): 261-3[PubMed]
  • 6. Magnesium sulphate as a novel treatment in resistant tic douloureux. Minerva anestesiologica. 2013; : 1
  • 7. James MF, Beer RE, Esser JD. Intravenous magnesium sulfate inhibits catecholamine release associated with tracheal intubation. Anesth Analg. 1989; 68(6): 772-6[PubMed]
  • 8. Laurant P, Touyz RM, Schiffrin EL. Effect of magnesium on vascular tone and reactivity in pressurized mesenteric resistance arteries from spontaneously hypertensive rats. Can J Physiol Pharmacol. 1997; 75(4): 293-300[PubMed]
  • 9. Jolliffe CT, Leece EA, Adams V, Marlin DJ. Effect of intravenous lidocaine on heart rate, systolic arterial blood pressure and cough responses to endotracheal intubation in propofol-anaesthetized dogs. Vet Anaesth Analg. 2007; 34(5): 322-30[DOI][PubMed]
  • 10. Mikawa K, Nishina K, Takao Y, Shiga M, Maekawa N, Obara H. Attenuation of cardiovascular responses to tracheal extubation: comparison of verapamil, lidocaine, and verapamil-lidocaine combination. Anesth Analg. 1997; 85(5): 1005-10[PubMed]
  • 11. Altura BT, Altura BM. Endothelium-dependent relaxation in coronary arteries requires magnesium ions. Br J Pharmacol. 1987; 91(3): 449-51[PubMed]
  • 12. Sanders GM, Sim KM. Is it feasible to use magnesium sulphate as a hypotensive agent in oral and maxillofacial surgery? Ann Acad Med Singapore. 1998; 27(6): 780-5[PubMed]
  • 13. Wong CH, Dey P, Yarmush J, Wu WH, Zbuzek VK. Nifedipine-induced analgesia after epidural injection in rats. Anesth Analg. 1994; 79(2): 303-6[PubMed]
  • 14. Do SH. Magnesium: a versatile drug for anesthesiologists. Korean J Anesthesiol. 2013; 65(1): 4-8[DOI][PubMed]
  • 15. Crozier TA, Radke J, Weyland A, Sydow M, Seyde W, Markakis E, et al. Haemodynamic and endocrine effects of deliberate hypotension with magnesium sulphate for cerebral-aneurysm surgery. Eur J Anaesthesiol. 1991; 8(2): 115-21[PubMed]
  • 16. Elsharnouby NM, Elsharnouby MM. Magnesium sulphate as a technique of hypotensive anaesthesia. Br J Anaesth. 2006; 96(6): 727-31[DOI][PubMed]
  • 17. Nakaigawa Y, Akazawa S, Shimizu R, Ishii R, Ikeno S, Inoue S, et al. Effects of magnesium sulphate on the cardiovascular system, coronary circulation and myocardial metabolism in anaesthetized dogs. Br J Anaesth. 1997; 79(3): 363-8[PubMed]
  • 18. Moharari RS, Motalebi M, Najafi A, Zamani M, Imani F, Etezadi F, et al. Magnesium Can Decrease Postoperative Physiological Ileus and Postoperative Pain in Major non Laparoscopic Gastrointestinal Surgeries: A Randomized Controlled Trial. Anesth Pain Med. 2014; 4(1)
  • 19. Shin YH, Choi SJ, Jeong HY, Kim MH. Evaluation of dose effects of magnesium sulfate on rocuronium injection pain and hemodynamic changes by laryngoscopy and endotracheal intubation. Korean J Anesthesiol. 2011; 60(5): 329-33[DOI][PubMed]
  • 20. Nastou H, Sarros G, Nastos A, Sarrou V, Anastassopoulou J. Prophylactic effects of intravenous magnesium on hypertensive emergencies after cataract surgery. A new contribution to the pharmacological use of magnesium in anaesthesiology. Magnes Res. 1995; 8(3): 271-6[PubMed]
  • 21. Delhumeau A, Granry J, Cottineau C, Bukowski J, Corbeau J, Moreau X. Comparative Vascular Effects of Magnesium Sulphate and Nicardipine during Cardiopulmonary Bypass. Ann Fr Anesth Re'anim. 1995; 141
  • 22. Ferasatkish R, Dabbagh A, Alavi M, Mollasadeghi G, Hydarpur E, Moghadam AA, et al. Effect of magnesium sulfate on extubation time and acute pain in coronary artery bypass surgery. Acta Anaesthesiol Scand. 2008; 52(10): 1348-52[DOI][PubMed]
  • 23. Yorukoglu D, Asik Y, Okten F. Rocuronium combined with i.v. lidocaine for rapid tracheal intubation. Acta Anaesthesiol Scand. 2003; 47(5): 583-7[PubMed]
  • 24. Pandey CK, Raza M, Ranjan R, Singhal V, Kumar M, Lakra A, et al. Intravenous lidocaine 0.5 effectively suppresses fentanyl-induced cough. Can J Anaesth. 2005; 52(2): 172-5[DOI][PubMed]
  • 25. Hassani V, Movassaghi G, Goodarzi V, Safari S. Comparison of fentanyl and fentanyl plus lidocaine on attenuation of hemodynamic responses to tracheal intubation in controlled hypertensive patients undergoing general anesthesia. Anesth Pain Med. 2013; 2(3): 115-8[DOI][PubMed]
  • 26. Miller CD, Warren SJ. IV lignocaine fails to attenuate the cardiovascular response to laryngoscopy and tracheal intubation. Br J Anaesth. 1990; 65(2): 216-9[PubMed]
  • 27. Singh H, Vichitvejpaisal P, Gaines GY, White PF. Comparative effects of lidocaine, esmolol, and nitroglycerin in modifying the hemodynamic response to laryngoscopy and intubation. J Clin Anesth. 1995; 7(1): 5-8[PubMed]
  • 28. Panda NB, Bharti N, Prasad S. Minimal effective dose of magnesium sulfate for attenuation of intubation response in hypertensive patients. J Clin Anesth. 2013; 25(2): 92-7[DOI][PubMed]
  • 29. Nooraei N, Dehkordi ME, Radpay B, Teimoorian H, Mohajerani SA. Effects of Intravenous Magnesium Sulfate and Lidocaine on Hemodynamic Variables Following Direct Laryngoscopy and Intubation in Elective Surgery Patients. Tanaffos. 2013; 12(1)
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments