Anesthesiology and Pain Medicine

Published by: Kowsar

The Effect of Single-Dose Administration of Dexamethasone on Postoperative Pain in Patients Undergoing Laparoscopic Cholecystectomy

Ahmadreza Mohtadi 1 , 2 , Sholeh Nesioonpour 1 , 2 , * , Amir Salari 1 , 2 , Reza Akhondzadeh 1 , 2 , Babak Masood Rad 1 , 2 and Seyed Mohammad Mehdi Aslani 1 , 2
Authors Information
1 Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Department of Anesthesiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Article information
  • Anesthesiology and Pain Medicine: August 01, 2014, 4 (3); e17872
  • Published Online: August 13, 2014
  • Article Type: Research Article
  • Received: February 25, 2014
  • Revised: April 26, 2014
  • Accepted: June 11, 2014
  • DOI: 10.5812/aapm.17872

To Cite: Mohtadi A, Nesioonpour S, Salari A, Akhondzadeh R, Masood Rad B, et al. The Effect of Single-Dose Administration of Dexamethasone on Postoperative Pain in Patients Undergoing Laparoscopic Cholecystectomy, Anesth Pain Med. 2014 ; 4(3):e17872. doi: 10.5812/aapm.17872.

Copyright © 2014, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Gousheh SM, Nesioonpour S, Javaher Foroosh F, Akhondzadeh R, Sahafi SA, Alizadeh Z. Intravenous paracetamol for postoperative analgesia in laparoscopic cholecystectomy. Anesth Pain Med. 2013; 3(1): 214-8[DOI][PubMed]
  • 2. Arroyo-Novoa CM, Figueroa-Ramos MI, Miaskowski C, Padilla G, Paul SM, Rodriguez-Ortiz P, et al. Efficacy of small doses of ketamine with morphine to decrease procedural pain responses during open wound care. Clin J Pain. 2011; 27(7): 561-6[DOI][PubMed]
  • 3. Benitez-Rosario MA, Salinas-Martin A, Gonzalez-Guillermo T, Feria M. A strategy for conversion from subcutaneous to oral ketamine in cancer pain patients: effect of a 1:1 ratio. J Pain Symptom Manage. 2011; 41(6): 1098-105[DOI][PubMed]
  • 4. Hessami MA, Yari M. Granisetron versus dexamethasone in prophylaxis of nausea and vomiting after laparoscopic cholecystectomy. Anesth Pain Med. 2012; 2(2): 81-4[DOI][PubMed]
  • 5. Lepner U, Goroshina J, Samarutel J. Postoperative pain relief after laparoscopic cholecystectomy: a randomised prospective double-blind clinical trial. Scand J Surg. 2003; 92(2): 121-4[PubMed]
  • 6. Sarvestani AS, Amini S, Kalhor M, Roshanravan R, Mohammadi M, Lebaschi AH. Intraperitoneal hydrocortisone for pain relief after laparoscopic cholecystectomy. Saudi J Anaesth. 2013; 7(1): 14-7[DOI][PubMed]
  • 7. Golubovic S, Golubovic V, Cindric-Stancin M, Tokmadzic VS. Intraperitoneal analgesia for laparoscopic cholecystectomy: bupivacaine versus bupivacaine with tramadol. Coll Antropol. 2009; 33(1): 299-302[PubMed]
  • 8. Nesioonpour S, Akhondzadeh R, Pipelzadeh MR, Rezaee S, Nazaree E, Soleymani M. The effect of preemptive analgesia with bupivacaine on postoperative pain of inguinal hernia repair under spinal anesthesia: a randomized clinical trial. Hernia. 2013; 17(4): 465-70[DOI][PubMed]
  • 9. Lim SH, Jang EH, Kim MH, Cho K, Lee JH, Lee KM, et al. Analgesic effect of preoperative versus intraoperative dexamethasone after laparoscopic cholecystectomy with multimodal analgesia. Korean J Anesthesiol. 2011; 61(4): 315-9[DOI][PubMed]
  • 10. De Oliveira GS, Jr, Ahmad S, Fitzgerald PC, Marcus RJ, Altman CS, Panjwani AS, et al. Dose ranging study on the effect of preoperative dexamethasone on postoperative quality of recovery and opioid consumption after ambulatory gynaecological surgery. Br J Anaesth. 2011; 107(3): 362-71[DOI][PubMed]
  • 11. Khalaj AR, Miri SR, Porlashkari M, Mohammadi A. Prophylactic Anti-Emetic Effect of Dexamethasone and Metoclopramide on the Nausea and Vomiting Induced by Laparoscopic Cholecystectomy: A Randomized, Double Blind, Placebo-Controlled Trial. J Minim Invasive Surg Sci. 2013; 2(1): 18-22
  • 12. Fukami Y, Terasaki M, Okamoto Y, Sakaguchi K, Murata T, Ohkubo M, et al. Efficacy of preoperative dexamethasone in patients with laparoscopic cholecystectomy: a prospective randomized double-blind study. J Hepatobiliary Pancreat Surg. 2009; 16(3): 367-71[DOI][PubMed]
  • 13. Elhakim M, Nafie M, Mahmoud K, Atef A. Dexamethasone 8 mg in combination with ondansetron 4 mg appears to be the optimal dose for the prevention of nausea and vomiting after laparoscopic cholecystectomy. Can J Anaesth. 2002; 49(9): 922-6[DOI][PubMed]
  • 14. Bisgaard T, Klarskov B, Rosenberg J, Kehlet H. Characteristics and prediction of early pain after laparoscopic cholecystectomy. Pain. 2001; 90(3): 261-9[PubMed]
  • 15. Murphy GS, Szokol JW, Greenberg SB, Avram MJ, Vender JS, Nisman M, et al. Preoperative dexamethasone enhances quality of recovery after laparoscopic cholecystectomy: effect on in-hospital and postdischarge recovery outcomes. Anesthesiology. 2011; 114(4): 882-90[DOI][PubMed]
  • 16. Callery MP. Preoperative steroids for laparoscopic surgery. Ann Surg. 2003; 238(5): 661-2[DOI][PubMed]
  • 17. Hargreaves KM, Costello A. Glucocorticoids suppress levels of immunoreactive bradykinin in inflamed tissue as evaluated by microdialysis probes. Clin Pharmacol Ther. 1990; 48(2): 168-78[PubMed]
  • 18. Waldron NH, Jones CA, Gan TJ, Allen TK, Habib AS. Impact of perioperative dexamethasone on postoperative analgesia and side-effects: systematic review and meta-analysis. Br J Anaesth. 2013; 110(2): 191-200[DOI][PubMed]
  • 19. De Oliveira GS, Jr, Almeida MD, Benzon HT, McCarthy RJ. Perioperative single dose systemic dexamethasone for postoperative pain: a meta-analysis of randomized controlled trials. Anesthesiology. 2011; 115(3): 575-88[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments