Anesthesiology and Pain Medicine

Published by: Kowsar

The Effect of Premenstrual Syndrome and Menstrual Phase on Postoperative Pain

Maliheh Arab 1 , 2 , * , Alireza Mirkheshti 3 , Giti Noghabaei 1 , Adeleh Ashori 1 , Tahereh Ghasemi 1 and Seyed Mostafa Hosseini-Zijoud 4
Authors Information
1 Preventative Gynecology Research Center (PGRC), Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Imam Hossein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Social Development and Health Promotion Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Article information
  • Anesthesiology and Pain Medicine: April 3, 2015, 5 (2); e19333
  • Published Online: April 20, 2015
  • Article Type: Research Article
  • Received: April 9, 2014
  • Revised: July 12, 2014
  • Accepted: October 19, 2014
  • DOI: 10.5812/aapm.19333

To Cite: Arab M, Mirkheshti A, Noghabaei G, Ashori A, Ghasemi T, et al. The Effect of Premenstrual Syndrome and Menstrual Phase on Postoperative Pain, Anesth Pain Med. 2015 ; 5(2):e19333. doi: 10.5812/aapm.19333.

Copyright © 2015, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Freeman EW. Premenstrual syndrome and premenstrual dysphoric disorder: definitions and diagnosis. Psychoneuroendocrinology. 2003; 28 Suppl 3: 25-37[PubMed]
  • 2. American College of Obstetrics and Gynecology . premenstrual syndrome. 2000;
  • 3. Derman O, Kanbur NO, Tokur TE, Kutluk T. Premenstrual syndrome and associated symptoms in adolescent girls. Eur J Obstet Gynecol Reprod Biol. 2004; 116(2): 201-6[DOI][PubMed]
  • 4. Ginsburg KA. Practical Strategies in Obstetrics and Gynecology. 2000;
  • 5. Halbreich U, Borenstein J, Pearlstein T, Kahn LS. The prevalence, impairment, impact, and burden of premenstrual dysphoric disorder (PMS/PMDD). Psychoneuroendocrinology. 2003; 28 Suppl 3: 1-23[PubMed]
  • 6. Hanci V, Ayoglu H, Yilmaz M, Yurtlu S, Okyay RD, Erdogan G, et al. Effect of menstrual cycle on the injection pain due to propofol. Eur J Anaesthesiol. 2010; 27(5): 425-7[DOI][PubMed]
  • 7. Halbreich U, Monacelli E. Some clues to the etiology of premenstrual syndrome/premenstrual dysphoric disorder. Prim Psychiatry. 2004; 11: 33-40
  • 8. Dickerson LM, Mazyck PJ, Hunter MH. Premenstrual syndrome. Am Fam Physician. 2003; 67(8): 1743-52[PubMed]
  • 9. Giannini AJ, Martin DM, Turner CE. Beta-endorphin decline in late luteal phase dysphoric disorder. Int J Psychiatry Med. 1990; 20(3): 279-84[PubMed]
  • 10. O'Brien S, Rapkin A, Dennerstein L, Nevatte T. Diagnosis and management of premenstrual disorders. BMJ. 2011; 342[DOI][PubMed]
  • 11. Beers MH, Fletcher AJ, Jones T, Porter R. Merck Manual Professional - Menstrual Abnormalitie. 2007;
  • 12. Rhudy JL, Bartley EJ. The effect of the menstrual cycle on affective modulation of pain and nociception in healthy women. Pain. 2010; 149(2): 365-72[DOI][PubMed]
  • 13. Hellstrom B, Anderberg UM. Pain perception across the menstrual cycle phases in women with chronic pain. Percept Mot Skills. 2003; 96(1): 201-11[DOI][PubMed]
  • 14. Sener EB, Kocamanoglu S, Cetinkaya MB, Ustun E, Bildik E, Tur A. Effects of menstrual cycle on postoperative analgesic requirements, agitation, incidence of nausea and vomiting after gynecological laparoscopy. Gynecol Obstet Invest. 2005; 59(1): 49-53
  • 15. Yamamoto K, Okazaki A, Sakamoto Y, Funatsu M. The relationship between premenstrual symptoms, menstrual pain, irregular menstrual cycles, and psychosocial stress among Japanese college students. J Physiol Anthropol. 2009; 28(3): 129-36[PubMed]
  • 16. ACOG . Premenstrual Syndrome - Faculty asked questions. 2011;
  • 17. Winderlich M. Stress and Your Menstrual Period: A Cycle That You Can Break. Everyday Health Media. 2013;
  • 18. Blue LS. tress Leads to Worse PMS Symptoms, Study Finds. 2010;
  • 19. Arab M, Manochehrian N, Mehrangiz Z. The Effect of Bupivacaine Infiltration on Postoperative Tubal-Ligation Pain. J Pain Symptom Manage. 2003; 3(1): 1-8
  • 20. Erden V, Yangin Z, Erkalp K, Delatioglu H, Bahceci F, Seyhan A. Increased progesterone production during the luteal phase of menstruation may decrease anesthetic requirement. Anesth Analg. 2005; 101(4): 1007-11[DOI][PubMed]
  • 21. Riley J3, Robinson ME, Wise EA, Price DD. A meta-analytic review of pain perception across the menstrual cycle. Pain. 1999; 81(3): 225-35[PubMed]
  • 22. Veith JL, Anderson J, Slade SA, Thompson P, Laugel GR, Getzlaf S. Plasma beta-endorphin, pain thresholds and anxiety levels across the human menstrual cycle. Physiol Behav. 1984; 32(1): 31-4[PubMed]
  • 23. Pfleeger M, Straneva PA, Fillingim RB, Maixner W, Girdler SS. Menstrual cycle, blood pressure and ischemic pain sensitivity in women: a preliminary investigation. Int J Psychophysiol. 1997; 27(2): 161-6[PubMed]
  • 24. Lenzmeier B, Moore RL, Cordts P, Garrett N. Menstrual cycle-related variations in postoperative analgesia with the preemptive use of N-methyl D-aspartate antagonist ketamine: a pilot study. Dimens Crit Care Nurs. 2008; 27(6): 271-6[DOI][PubMed]
  • 25. Ahmed A, Khan F, Ali M, Haqnawaz F, Hussain A, Azam SI. Effect of the menstrual cycle phase on post-operative pain perception and analgesic requirements. Acta Anaesthesiol Scand. 2012; 56(5): 629-35[DOI][PubMed]
  • 26. Macintyre PE, Schug SA. Acute Pain Management: A Practical Guide. 2007;
  • 27. Viana Ede S, da Silva SB, de Sousa MB. [Perception of ischemic and pressing pain in young women during menstrual cycle. Association with humor and cortisol levels]. Acta Cir Bras. 2005; 20 Suppl 1: 220-6[PubMed]
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