Anesthesiology and Pain Medicine

Published by: Kowsar

Addition of Intrathecal Magnesium Sulfate to Bupivacaine for Spinal Anesthesia in Cesarean Section

Nadia Banihashem 1 , Bahman Hasannasab 1 , * , Ali Esmaeili 1 and Borhaneh Hasannasab 2
Authors Information
1 Department of Anesthesiology, Babol University of Medical Sciences, Babol, IR Iran
2 Department of Pharmacology, Babol University of Medical Sciences, Babol, IR Iran
Article information
  • Anesthesiology and Pain Medicine: June 01, 2015, 5 (3); e22798
  • Published Online: June 22, 2015
  • Article Type: Research Article
  • Received: August 20, 2014
  • Revised: October 12, 2014
  • Accepted: November 2, 2014
  • DOI: 10.5812/aapm.5(3)2015.22798

To Cite: Banihashem N, Hasannasab B, Esmaeili A, Hasannasab B. Addition of Intrathecal Magnesium Sulfate to Bupivacaine for Spinal Anesthesia in Cesarean Section, Anesth Pain Med. 2015 ; 5(3):e22798. doi: 10.5812/aapm.5(3)2015.22798.

Copyright © 2015, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
4. Results
5. Discussion
  • 1. Roelants F. The use of neuraxial adjuvant drugs (neostigmine, clonidine) in obstetrics. Curr Opin Anaesthesiol. 2006; 19(3): 233-7[PubMed]
  • 2. Rasooli S, Parish M, Mahmoodpoor A, Moslemi F, Sanaie S. Effect of spinal low dose bupivacaine-sufentanyl for cesarean section in preeclamptic parturients on neonatal outcome. Shiraz E Med J. 2009; 10(4): 201-8
  • 3. Saxena AK, Arava SK. Current concepts in neuraxial administration of opioids and non-opioids: An overview and future perspectives. Indian J Anaesth. 2004; 48(1): 13-24
  • 4. Faiz SH, Rahimzadeh P, Imani F, Bakhtiari A. Intrathecal injection of magnesium sulfate: shivering prevention during cesarean section: a randomized, double-blinded, controlled study. Korean J Anesthesiol. 2013; 65(4): 293-8[PubMed]
  • 5. Lee AR, Yi HW, Chung IS, Ko JS, Ahn HJ, Gwak MS, et al. Magnesium added to bupivacaine prolongs the duration of analgesia after interscalene nerve block. Can J Anaesth. 2012; 59(1): 21-7[DOI][PubMed]
  • 6. Pascual-Ramirez J, Gil-Trujillo S, Alcantarilla C. Intrathecal magnesium as analgesic adjuvant for spinal anesthesia: a meta-analysis of randomized trials. Minerva Anestesiol. 2013; 79(6): 667-78[PubMed]
  • 7. Faiz SH, Rahimzadeh P, Sakhaei M, Imani F, Derakhshan P. Anesthetic effects of adding intrathecal neostigmine or magnesium sulphate to bupivacaine in patients under lower extremities surgeries. J Res Med Sci. 2012; 17(10): 918-22[PubMed]
  • 8. Khalili G, Janghorbani M, Sajedi P, Ahmadi G. Effects of adjunct intrathecal magnesium sulfate to bupivacaine for spinal anesthesia: a randomized, double-blind trial in patients undergoing lower extremity surgery. J Anesth. 2011; 25(6): 892-7[PubMed]
  • 9. Koinig H, Wallner T, Marhofer P, Andel H, Horauf K, Mayer N. Magnesium sulfate reduces intra- and postoperative analgesic requirements. Anesth Analg. 1998; 87(1): 206-10[PubMed]
  • 10. Tramer MR, Schneider J, Marti RA, Rifat K. Role of magnesium sulfate in postoperative analgesia. Anesthesiology. 1996; 84(2): 340-7[PubMed]
  • 11. Ozalevli M, Cetin TO, Unlugenc H, Guler T, Isik G. The effect of adding intrathecal magnesium sulphate to bupivacaine-fentanyl spinal anaesthesia. Acta Anaesthesiol Scand. 2005; 49(10): 1514-9[DOI][PubMed]
  • 12. Shoeibi G, Firozian A, Tabassomi F. The Additional Effect of Magnesium Sulfate to Lidocaine in Spinal Anesthesia for Cesarean Section. Int J Pharmacol. 2007; 3(5): 425-7[DOI]
  • 13. Shariat Moharari R, Motalebi M, Najafi A, Zamani MM, Imani F, Etezadi F, et al. Magnesium Can Decrease Postoperative Physiological Ileus and Postoperative Pain in Major non Laparoscopic Gastrointestinal Surgeries: A Randomized Controlled Trial. Anesth Pain Med. 2014; 4(1)[DOI][PubMed]
  • 14. Arcioni R, Palmisani S, Tigano S, Santorsola C, Sauli V, Romano S, et al. Combined intrathecal and epidural magnesium sulfate supplementation of spinal anesthesia to reduce post-operative analgesic requirements: a prospective, randomized, double-blind, controlled trial in patients undergoing major orthopedic surgery. Acta Anaesthesiol Scand. 2007; 51(4): 482-9[DOI][PubMed]
  • 15. Ghrab BE, Maatoug M, Kallel N, Khemakhem K, Chaari M, Kolsi K, et al. [Does combination of intrathecal magnesium sulfate and morphine improve postcaesarean section analgesia?]. Ann Fr Anesth Reanim. 2009; 28(5): 454-9[DOI][PubMed]
  • 16. Buvanendran A, McCarthy RJ, Kroin JS, Leong W, Perry P, Tuman KJ. Intrathecal magnesium prolongs fentanyl analgesia: a prospective, randomized, controlled trial. Anesth Analg. 2002; 95(3): 661-6[PubMed]
  • 17. Jabalameli M, Pakzadmoghadam SH. Adding different doses of intrathecal magnesium sulfate for spinal anesthesia in the cesarean section: A prospective double blind randomized trial. Adv Biomed Res. 2012; 1: 7[DOI][PubMed]
  • 18. Unlugenc H, Ozalevli M, Gunduz M, Gunasti S, Urunsak IF, Guler T, et al. Comparison of intrathecal magnesium, fentanyl, or placebo combined with bupivacaine 0.5% for parturients undergoing elective cesarean delivery. Acta Anaesthesiol Scand. 2009; 53(3): 346-53[PubMed]
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