Anesthesiology and Pain Medicine

Published by: Kowsar

The Effects of Topical Sesame (Sesamum indicum) Oil on Pain Severity and Amount of Received Non-Steroid Anti-Inflammatory Drugs in Patients With Upper or Lower Extremities Trauma

Marzieh Beigom Bigdeli Shamloo 1 , Morteza Nasiri 2 , * , Aazam Dabirian 3 , Ali Bakhtiyari 4 , Faraz Mojab 5 and Hamid Alavi Majd 6
Authors Information
1 Department of Nursing, Nursing and Midwifery School, Dezful University of Medical Sciences, Dezful, Iran
2 Department of Nursing, Nursing and Midwifery School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Department of Pharmacognosy, Nursing and Midwifery School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Department of Emergency Medicine, Medicine School, Dezful University of Medical Sciences, Dezful, Iran
5 Pharmacy School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6 Department of Epidemiology and Statistic, Health School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Article information
  • Anesthesiology and Pain Medicine: June 01, 2015, 5 (3); e25085
  • Published Online: June 22, 2015
  • Article Type: Research Article
  • Received: November 2, 2014
  • Revised: November 27, 2014
  • Accepted: January 7, 2015
  • DOI: 10.5812/aapm.25085v2

To Cite: Bigdeli Shamloo M B, Nasiri M, Dabirian A, Bakhtiyari A, Mojab F, et al. The Effects of Topical Sesame (Sesamum indicum) Oil on Pain Severity and Amount of Received Non-Steroid Anti-Inflammatory Drugs in Patients With Upper or Lower Extremities Trauma, Anesth Pain Med. 2015 ; 5(3):e25085. doi: 10.5812/aapm.25085v2.

Copyright © 2015, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Probst C, Pape HC, Hildebrand F, Regel G, Mahlke L, Giannoudis P, et al. 30 years of polytrauma care: An analysis of the change in strategies and results of 4849 cases treated at a single institution. Injury. 2009; 40(1): 77-83[DOI][PubMed]
  • 2. Norouzi V, Feizi I, Vatankhah S, Pourshaikhian M. Calculation of the probability of survival for trauma patients based on trauma score and the injury severity score model in fatemi hospital in ardabil. Arch Trauma Res. 2013; 2(1): 30-5[DOI][PubMed]
  • 3. Mock C, Cherian MN. The global burden of musculoskeletal injuries: challenges and solutions. Clin Orthop Relat Res. 2008; 466(10): 2306-16[DOI][PubMed]
  • 4. Ootes D, Lambers KT, Ring DC. The epidemiology of upper extremity injuries presenting to the emergency department in the United States. Hand (N Y). 2012; 7(1): 18-22[DOI][PubMed]
  • 5. Lambers K, Ootes D, Ring D. Incidence of patients with lower extremity injuries presenting to US emergency departments by anatomic region, disease category, and age. Clin Orthop Relat Res. 2012; 470(1): 284-90[DOI][PubMed]
  • 6. Adib-Hajbaghery M, Maghaminejad F. Epidemiology of patients with multiple trauma and the quality of their prehospital respiration management in kashan, iran: six months assessment. Arch Trauma Res. 2014; 3(2)[DOI][PubMed]
  • 7. Hanche-Olsen TP, Alemu L, Viste A, Wisborg T, Hansen KS. Trauma care in Africa: a status report from Botswana, guided by the World Health Organization's "Guidelines for Essential Trauma Care". World J Surg. 2012; 36(10): 2371-83[DOI][PubMed]
  • 8. Fraga GP, Quintas ML, Abib Sde C. Trauma and emergency: is the unified health system (SUS) the solution in Brazil? Rev Col Bras Cir. 2014; 41(4): 232-3[PubMed]
  • 9. Rosenbloom BN, Khan S, McCartney C, Katz J. Systematic review of persistent pain and psychological outcomes following traumatic musculoskeletal injury. J Pain Res. 2013; 6: 39-51[DOI][PubMed]
  • 10. Castillo RC, MacKenzie EJ, Wegener ST, Bosse MJ, Leap Study Group . Prevalence of chronic pain seven years following limb threatening lower extremity trauma. Pain. 2006; 124(3): 321-9[DOI][PubMed]
  • 11. Rivara FP, Mackenzie EJ, Jurkovich GJ, Nathens AB, Wang J, Scharfstein DO. Prevalence of pain in patients 1 year after major trauma. Arch Surg. 2008; 143(3): 282-7[DOI][PubMed]
  • 12. Kaske S, Lefering R, Trentzsch H, Driessen A, Bouillon B, Maegele M, et al. Quality of life two years after severe trauma: A single centre evaluation. Injury. 2014; 45 Suppl 3-5[DOI][PubMed]
  • 13. Dijkstra BM, Berben SA, van Dongen RT, Schoonhoven L. Review on pharmacological pain management in trauma patients in (pre-hospital) emergency medicine in the Netherlands. Eur J Pain. 2014; 18(1): 3-19[DOI][PubMed]
  • 14. Crofford LJ. Adverse effects of chronic opioid therapy for chronic musculoskeletal pain. Nat Rev Rheumatol. 2010; 6(4): 191-7[DOI][PubMed]
  • 15. Pountos I. Nonsteroidal anti-inflammatory drugs: prostaglandins, indications, and side effects. IJIM. 2011; 3(1): 19-27
  • 16. Teslim OA. Side Effects of Non-Steroidal Anti-Inflammatory Drugs: The Experience of Patients with Musculoskeletal Disorders. American J Health Res. 2014; 2(4): 106[DOI]
  • 17. Labianca R, Sarzi-Puttini P, Zuccaro SM, Cherubino P, Vellucci R, Fornasari D. Adverse effects associated with non-opioid and opioid treatment in patients with chronic pain. Clin Drug Invest. 2012; 32(1): 53-63
  • 18. Cantor JB, Gumber S. Use of Complementary and Alternative Medicine in Treating Individuals with Traumatic Brain Injury. Curr Phys Med Rehabil Rep. 2013; 1(3): 159-68
  • 19. Ernst E, Chrubasik S. Phyto-anti-inflammatories. A systematic review of randomized, placebo-controlled, double-blind trials. Rheum Dis Clin North Am. 2000; 26(1): 13-27[PubMed]
  • 20. Kucera M, Barna M, Horacek O, Kovarikova J, Kucera A. Efficacy and safety of topically applied Symphytum herb extract cream in the treatment of ankle distortion: results of a randomized controlled clinical double blind study. Wien Med Wochenschr. 2004; 154(21-22): 498-507[PubMed]
  • 21. Koll R, Buhr M, Dieter R, Pabst H, Predel HG, Petrowicz O, et al. Efficacy and tolerance of a comfrey root extract (Extr. Rad. Symphyti) in the treatment of ankle distorsions: results of a multicenter, randomized, placebo-controlled, double-blind study. Phytomedicine. 2004; 11(6): 470-7[DOI][PubMed]
  • 22. Predel HG, Giannetti B, Koll R, Bulitta M, Staiger C. Efficacy of a comfrey root extract ointment in comparison to a diclofenac gel in the treatment of ankle distortions: results of an observer-blind, randomized, multicenter study. Phytomedicine. 2005; 12(10): 707-14[DOI][PubMed]
  • 23. Hsu DZ, Chen SJ, Chu PY, Liu MY. Therapeutic effects of sesame oil on monosodium urate crystal-induced acute inflammatory response in rats. Springerplus. 2013; 2: 659[DOI][PubMed]
  • 24. Saleem TSM, Basha SD, Mahesh G, Rani PVS, Kumar NS, Chetty CM. Analgesic, anti-pyretic and anti-inflammatory activity of dietary sesame oil in experimental animal models. Pharmacologia. 2011; 2(6): 172-7
  • 25. Monteiro EM, Chibli LA, Yamamoto CH, Pereira MC, Vilela FM, Rodarte MP, et al. Antinociceptive and anti-inflammatory activities of the sesame oil and sesamin. Nutrients. 2014; 6(5): 1931-44[DOI][PubMed]
  • 26. Gauthaman K. Nutraceutical value of sesame oil. Pharmacognosy Rev. 2009; 3(6): 264
  • 27. Sadeghi N, Oveisi MR, Hajimahmoodi M, Jannat B, Mazaheri M, Mansouri S. The contents of sesamol in Iranian sesame seeds. Iranian J Pharm Res. 2010; : 101-5
  • 28. Reiser MC. Comparing the visual analog scale and verbally administered numeric rating scale in traumatic versus non-traumatic causes of pain in an academic medical level 1 trauma emergency department. 2010;
  • 29. Eftekhar Sadat B, Khadem Haghighian M, Alipoor B, Malek Mahdavi A, Asghari Jafarabadi M, Moghaddam A. Effects of sesame seed supplementation on clinical signs and symptoms in patients with knee osteoarthritis. Int J Rheum Dis. 2013; 16(5): 578-82[DOI][PubMed]
  • 30. Nekuzad N, Ashke Torab T, Mojab F, Alavi-Majd H, Azadeh P, Ehtejab G. Effect of external use of sesame oil in the prevention of chemotherapy-induced phlebitis. Iran J Pharm Res. 2012; 11(4): 1065-71[PubMed]
  • 31. Newman DJ, Cragg GM. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod. 2012; 75(3): 311-35[DOI][PubMed]
  • 32. Hirsch T, Ashkar W, Schumacher O, Steinstraesser L, Ingianni G, Cedidi C. Moist exposed burn ointment (mebo) in partial thickness burns. Eur J Med Res. 2008; 13: 505-10
  • 33. Rangkadilok N, Pholphana N, Mahidol C, Wongyai W, Saengsooksree K, Nookabkaew S, et al. Variation of sesamin, sesamolin and tocopherols in sesame (Sesamum indicum L.) seeds and oil products in Thailand. Food Chemistry. 2010; 122(3): 724-30[DOI]
  • 34. Deciga-Campos M, Montiel-Ruiz RM, Navarrete-Vazquez G, Lopez-Munoz FJ. Palmitic acid analogues exhibiting antinociceptive activity in mice. Proc West Pharmacol Soc. 2007; 50: 75-7[PubMed]
  • 35. Carvalho RHR, Galvão EL, Barros JC, Conceição MM, Sousa EMBD. Extraction, fatty acid profile and antioxidant activity of sesame extract (Sesamum Indicum L.). Braz J Chem Eng. 2012; 29(2): 409-20[DOI]
  • 36. Kupeli E, Erdemoglu N, Yesilada E, Sener B. Anti-inflammatory and antinociceptive activity of taxoids and lignans from the heartwood of Taxus baccata L. J Ethnopharmacol. 2003; 89(2-3): 265-70[PubMed]
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