Anesthesiology and Pain Medicine

Published by: Kowsar

Comparison of the Effects of Magnesium Sulfate and Remifentanil on Hemodynamic Responses During Tracheal Extubation After Laparotomy: A Randomized Double-blinded Trial

Seyed Mojtaba Marashi 1 , Reza Hassan Nikkhouei 1 , Ali Movafegh 1 , Gita Shoeibi 1 and Shaqayeq Marashi 1 , *
Authors Information
1 Anesthesiology Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Article information
  • Anesthesiology and Pain Medicine: August 01, 2015, 5 (4); e25276
  • Published Online: August 26, 2015
  • Article Type: Research Article
  • Received: November 11, 2014
  • Revised: February 15, 2015
  • Accepted: April 12, 2015
  • DOI: 10.5812/aapm.25276

To Cite: Marashi S M, Hassan Nikkhouei R, Movafegh A, Shoeibi G, Marashi S. Comparison of the Effects of Magnesium Sulfate and Remifentanil on Hemodynamic Responses During Tracheal Extubation After Laparotomy: A Randomized Double-blinded Trial, Anesth Pain Med. 2015 ; 5(4):e25276. doi: 10.5812/aapm.25276.

Copyright © 2015, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
4. Results
5. Discussion
  • 1. Artime CA, Hagberg CA. Tracheal extubation. Respir Care. 2014; 59(6): 991-1002[DOI][PubMed]
  • 2. Cavallone LF, Vannucci A. Review article: Extubation of the difficult airway and extubation failure. Anesth Analg. 2013; 116(2): 368-83[DOI][PubMed]
  • 3. Asai T, Koga K, Vaughan RS. Respiratory complications associated with tracheal intubation and extubation. Br J Anaesth. 1998; 80(6): 767-75[PubMed]
  • 4. Rassam S, Sandbythomas M, Vaughan RS, Hall JE. Airway management before, during and after extubation: a survey of practice in the United Kingdom and Ireland. Anaesthesia. 2005; 60(10): 995-1001[DOI][PubMed]
  • 5. Miller KA, Harkin CP, Bailey PL. Postoperative tracheal extubation. Anesth Analg. 1995; 80(1): 149-72[PubMed]
  • 6. Magnusson L, Spahn DR. New concepts of atelectasis during general anaesthesia. Br J Anaesth. 2003; 91(1): 61-72[PubMed]
  • 7. van Zijl DH, Gordon PC, James MF. The comparative effects of remifentanil or magnesium sulfate versus placebo on attenuating the hemodynamic responses after electroconvulsive therapy. Anesth Analg. 2005; 101(6): 1651-5[DOI][PubMed]
  • 8. Dube L, Granry JC. The therapeutic use of magnesium in anesthesiology, intensive care and emergency medicine: a review. Can J Anaesth. 2003; 50(7): 732-46[DOI][PubMed]
  • 9. Prielipp RC, Zaloga GP, Butterworth J, Robertie PG, Dudas LM, Black KW, et al. Magnesium inhibits the hypertensive but not the cardiotonic actions of low-dose epinephrine. Anesthesiology. 1991; 74(6): 973-9[PubMed]
  • 10. Shariat Moharari R, Motalebi M, Najafi A, Zamani MM, Imani F, Etezadi F, et al. Magnesium Can Decrease Postoperative Physiological Ileus and Postoperative Pain in Major non Laparoscopic Gastrointestinal Surgeries: A Randomized Controlled Trial. Anesth Pain Med. 2014; 4(1)[DOI][PubMed]
  • 11. Mayer DB, Miletich DJ, Feld JM, Albrecht RF. The effects of magnesium salts on the duration of epinephrine-induced ventricular tachyarrhythmias in anesthetized rats. Anesthesiology. 1989; 71(6): 923-8[PubMed]
  • 12. Beers R, Camporesi E. Remifentanil update: clinical science and utility. CNS Drugs. 2004; 18(15): 1085-104[PubMed]
  • 13. Michelsen LC. The pharmakokionetics of remifentanil. J Clin Anesth. 1996; 8: 679-82[DOI]
  • 14. Scholz J, Steinfath M. [Is remifentanil an ideal opioid for anesthesiologic management in the 21st century?]. Anasthesiol Intensivmed Notfallmed Schmerzther. 1996; 31(10): 592-607[DOI][PubMed]
  • 15. Smith T. Ethics in medical research. 1990; : 12–49
  • 16. Lim SH, An DG, Choi SW, Lee SE, Kim YH, Lee JH, et al. The Comparison of Magnesium Sulfate and Remifentanil in Attenuating Hemodynamic Response to Endotracheal Intubation. Korean J Anesthesiol. 2007; 53(5): 577-82
  • 17. Kim SY, Yang SY, Na SW, Jo YY, Koh SO. Low-dose remifentanil infusion during ventilator weaning and tracheal extubation in postoperative intensive care unit patients sedated with propofol-remifentanil: a randomised clinical trial. Anaesth Intensive Care. 2012; 40(4): 656-62[PubMed]
  • 18. Wu J, Liu L, Yang F. [Effect of small-dose remifentanil on cardiovascular response to tracheal extubation after general anesthesia]. Nan Fang Yi Ke Da Xue Xue Bao. 2012; 32(9): 1316-8[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments