Anesthesiology and Pain Medicine

Published by: Kowsar

Efficacy of Pregabalin in the Treatment of Radicular Pain: Results of a Controlled Trial

Khalid M. Malik 1 , * , Ariana M. Nelson 1 , Michael J. Avram 1 , Sabrina Lee Robak 1 and Honorio T. Benzon 1
Authors Information
1 Department of Anesthesiology, Northwestern University, Chicago IL, USA
Article information
  • Anesthesiology and Pain Medicine: August 01, 2015, 5 (4); e28110
  • Published Online: August 22, 2015
  • Article Type: Research Article
  • Received: February 24, 2015
  • Accepted: March 29, 2015
  • DOI: 10.5812/aapm.28110

To Cite: Malik K M, M. Nelson A, J. Avram M, Lee Robak S, T. Benzon H. Efficacy of Pregabalin in the Treatment of Radicular Pain: Results of a Controlled Trial, Anesth Pain Med. 2015 ; 5(4):e28110. doi: 10.5812/aapm.28110.

Copyright © 2015, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Wiffen PJ, Derry S, Moore RA, Aldington D, Cole P, Rice AS, et al. Antiepileptic drugs for neuropathic pain and fibromyalgia - an overview of Cochrane reviews. Cochrane Database Syst Rev. 2013; 11[DOI][PubMed]
  • 2. Parke-Davis Division of Pfizer Inc. 2013;
  • 3. Merskey H, Bogduk N. Classification of chronic pain: description of chronic pain syndromes and definitions of pain terms. 1994;
  • 4. Backonja MM. Defining neuropathic pain. Anesth Analg. 2003; 97(3): 785-90[PubMed]
  • 5. Dworkin RH, Backonja M, Rowbotham MC, Allen RR, Argoff CR, Bennett GJ, et al. Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations. Arch Neurol. 2003; 60(11): 1524-34[DOI][PubMed]
  • 6. Stafford MA, Peng P, Hill DA. Sciatica: a review of history, epidemiology, pathogenesis, and the role of epidural steroid injection in management. Br J Anaesth. 2007; 99(4): 461-73[DOI][PubMed]
  • 7. Wall PD, Devor M. Sensory afferent impulses originate from dorsal root ganglia as well as from the periphery in normal and nerve injured rats. Pain. 1983; 17(4): 321-39[PubMed]
  • 8. Howe JF, Loeser JD, Calvin WH. Mechanosensitivity of dorsal root ganglia and chronically injured axons: a physiological basis for the radicular pain of nerve root compression. Pain. 1977; 3(1): 25-41[PubMed]
  • 9. Deyo RA, Tsui-Wu YJ. Descriptive epidemiology of low-back pain and its related medical care in the United States. Spine (Phila Pa 1976). 1987; 12(3): 264-8[PubMed]
  • 10. Frymoyer JW, Cats-Baril WL. An overview of the incidences and costs of low back pain. Orthop Clin North Am. 1991; 22(2): 263-71[PubMed]
  • 11. Svensson HO, Andersson GB. Low-back pain in 40- to 47-year-old men: work history and work environment factors. Spine (Phila Pa 1976). 1983; 8(3): 272-6[PubMed]
  • 12. Farrar JT, Young JJ, LaMoreaux L, Werth JL, Poole RM. Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale. Pain. 2001; 94(2): 149-58[PubMed]
  • 13. Fairbank JC, Couper J, Davies JB, O'Brien JP. The Oswestry low back pain disability questionnaire. Physiotherapy. 1980; 66(8): 271-3[PubMed]
  • 14. Hurst H, Bolton J. Assessing the clinical significance of change scores recorded on subjective outcome measures. J Manipulative Physiol Ther. 2004; 27(1): 26-35[DOI][PubMed]
  • 15. Siddall PJ, Cousins MJ, Otte A, Griesing T, Chambers R, Murphy TK. Pregabalin in central neuropathic pain associated with spinal cord injury: a placebo-controlled trial. Neurology. 2006; 67(10): 1792-800[DOI][PubMed]
  • 16. Sabatowski R, Galvez R, Cherry DA, Jacquot F, Vincent E, Maisonobe P, et al. Pregabalin reduces pain and improves sleep and mood disturbances in patients with post-herpetic neuralgia: results of a randomised, placebo-controlled clinical trial. Pain. 2004; 109(1-2): 26-35[DOI][PubMed]
  • 17. van Seventer R, Feister HA, Young JJ, Stoker M, Versavel M, Rigaudy L. Efficacy and tolerability of twice-daily pregabalin for treating pain and related sleep interference in postherpetic neuralgia: a 13-week, randomized trial. Curr Med Res Opin. 2006; 22(2): 375-84[DOI][PubMed]
  • 18. Lesser H, Sharma U, LaMoreaux L, Poole RM. Pregabalin relieves symptoms of painful diabetic neuropathy: a randomized controlled trial. Neurology. 2004; 63(11): 2104-10[PubMed]
  • 19. Richter RW, Portenoy R, Sharma U, Lamoreaux L, Bockbrader H, Knapp LE. Relief of painful diabetic peripheral neuropathy with pregabalin: a randomized, placebo-controlled trial. J Pain. 2005; 6(4): 253-60[DOI][PubMed]
  • 20. Arnold LM, Russell IJ, Diri EW, Duan WR, Young JJ, Sharma U, et al. A 14-week, randomized, double-blinded, placebo-controlled monotherapy trial of pregabalin in patients with fibromyalgia. J Pain. 2008; 9(9): 792-805[DOI][PubMed]
  • 21. Baron R, Freynhagen R, Tolle TR, Cloutier C, Leon T, Murphy TK, et al. The efficacy and safety of pregabalin in the treatment of neuropathic pain associated with chronic lumbosacral radiculopathy. Pain. 2010; 150(3): 420-7[DOI][PubMed]
  • 22. Lo YL, Cheong PW, George JM, Tan SB, Yue WM, Guo CM, et al. Pregabalin and Radicular Pain Study (PARPS) for Cervical Spondylosis in a Multiracial Asian Population. J Clin Med Res. 2014; 6(1): 66-71[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments