Anesthesiology and Pain Medicine

Published by: Kowsar

Influence of Ketamine on Early Postoperative Cognitive Function After Orthopedic Surgery in Elderly Patients

Ki Hwa Lee 1 , Ji Yeon Kim 2 , Jeong Won Kim 2 , Jang Su Park 2 , * , Kyu Won Lee 1 and Sang Yoon Jeon 3
Authors Information
1 Department of Anesthesia and Pain Medicine, Haeundae Paik Hospital, Inje University, Busan, South Korea
2 Department of Anesthesia and Pain Medicine, Ilsan Paik Hospital, Inje University, Goyang, South Korea
3 Department of Anesthesia and Pain Medicine, Halla Hospital, Jeju, South Korea
Article information
  • Anesthesiology and Pain Medicine: October 01, 2015, 5 (5); e28844
  • Published Online: October 17, 2015
  • Article Type: Research Article
  • Received: March 24, 2015
  • Revised: May 11, 2015
  • Accepted: June 6, 2015
  • DOI: 10.5812/aapm.28844

To Cite: Lee K H, Kim J Y, Kim J W, Park J S, Lee K W, et al. Influence of Ketamine on Early Postoperative Cognitive Function After Orthopedic Surgery in Elderly Patients, Anesth Pain Med. 2015 ; 5(5):e28844. doi: 10.5812/aapm.28844.

Copyright © 2015, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Deiner S, Silverstein JH. Postoperative delirium and cognitive dysfunction. Br J Anaesth. 2009; 103 Suppl 1-6[DOI][PubMed]
  • 2. Monk TG, Weldon BC, Garvan CW, Dede DE, van der Aa MT, Heilman KM, et al. Predictors of cognitive dysfunction after major noncardiac surgery. Anesthesiology. 2008; 108(1): 18-30[DOI][PubMed]
  • 3. Newman MF, Kirchner JL, Phillips-Bute B, Gaver V, Grocott H, Jones RH, et al. Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery. N Engl J Med. 2001; 344(6): 395-402[DOI][PubMed]
  • 4. Postler A, Neidel J, Gunther KP, Kirschner S. Incidence of early postoperative cognitive dysfunction and other adverse events in elderly patients undergoing elective total hip replacement (THR). Arch Gerontol Geriatr. 2011; 53(3): 328-33[DOI][PubMed]
  • 5. Rohan D, Buggy DJ, Crowley S, Ling FK, Gallagher H, Regan C, et al. Increased incidence of postoperative cognitive dysfunction 24 hr after minor surgery in the elderly. Can J Anaesth. 2005; 52(2): 137-42[DOI][PubMed]
  • 6. Bekker AY, Weeks EJ. Cognitive function after anaesthesia in the elderly. Best Pract Res Clin Anaesthesiol. 2003; 17(2): 259-72[PubMed]
  • 7. Yaffe K, Lindquist K, Penninx BW, Simonsick EM, Pahor M, Kritchevsky S, et al. Inflammatory markers and cognition in well-functioning African-American and white elders. Neurology. 2003; 61(1): 76-80[PubMed]
  • 8. Wersching H, Duning T, Lohmann H, Mohammadi S, Stehling C, Fobker M, et al. Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function. Neurology. 2010; 74(13): 1022-9[DOI][PubMed]
  • 9. Komulainen P, Lakka TA, Kivipelto M, Hassinen M, Penttila IM, Helkala EL, et al. Serum high sensitivity C-reactive protein and cognitive function in elderly women. Age Ageing. 2007; 36(4): 443-8[DOI][PubMed]
  • 10. Beloosesky Y, Hendel D, Weiss A, Hershkovitz A, Grinblat J, Pirotsky A, et al. Cytokines and C-reactive protein production in hip-fracture-operated elderly patients. J Gerontol A Biol Sci Med Sci. 2007; 62(4): 420-6[PubMed]
  • 11. Hudetz JA, Patterson KM, Iqbal Z, Gandhi SD, Byrne AJ, Hudetz AG, et al. Ketamine attenuates delirium after cardiac surgery with cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 2009; 23(5): 651-7[DOI][PubMed]
  • 12. Hudetz JA, Iqbal Z, Gandhi SD, Patterson KM, Byrne AJ, Hudetz AG, et al. Ketamine attenuates post-operative cognitive dysfunction after cardiac surgery. Acta Anaesthesiol Scand. 2009; 53(7): 864-72[DOI][PubMed]
  • 13. Moller JT, Cluitmans P, Rasmussen LS, Houx P, Rasmussen H, Canet J, et al. Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction. Lancet. 1998; 351(9106): 857-61[PubMed]
  • 14. Rasmussen LS. Postoperative cognitive dysfunction: incidence and prevention. Best Pract Res Clin Anaesthesiol. 2006; 20(2): 315-30[PubMed]
  • 15. Hosseini K, Amouei M, Alemohammad M. Evaluating the Postoperative Complications of Coronary Artery Bypass Graft Surgery in the Elderly. Thrita. 2014; 3(3)[DOI]
  • 16. Chan MT, Cheng BC, Lee TM, Gin T, Coda Trial Group. . BIS-guided anesthesia decreases postoperative delirium and cognitive decline. J Neurosurg Anesthesiol. 2013; 25(1): 33-42[DOI][PubMed]
  • 17. Meineke M, Applegate R2, Rasmussen T, Anderson D, Azer S, Mehdizadeh A, et al. Cognitive dysfunction following desflurane versus sevoflurane general anesthesia in elderly patients: a randomized controlled trial. Med Gas Res. 2014; 4(1): 6[DOI][PubMed]
  • 18. Kim BJ, Kim SO, Park JW. Cognitive Changes after Open Heart Surgery with Cardiopulmonary Bypass. Korean J Anesthesiol. 2004; 47(6): 816-23
  • 19. Green MS, Green P, Neubert L, Voralu K, Saththasivam P, Mychaskiw G. Recovery following desflurane versus sevoflurane anesthesia for outpatient urologic surgery in elderly females. Anesth Pain Med. 2015; 5(1)[DOI][PubMed]
  • 20. Kotekar N, Kuruvilla CS, Murthy V. Post-operative cognitive dysfunction in the elderly: A prospective clinical study. Indian J Anaesth. 2014; 58(3): 263-8[DOI][PubMed]
  • 21. Newman S, Stygall J, Hirani S, Shaefi S, Maze M. Postoperative cognitive dysfunction after noncardiac surgery: a systematic review. Anesthesiology. 2007; 106(3): 572-90[PubMed]
  • 22. Rortgen D, Kloos J, Fries M, Grottke O, Rex S, Rossaint R, et al. Comparison of early cognitive function and recovery after desflurane or sevoflurane anaesthesia in the elderly: a double-blinded randomized controlled trial. Br J Anaesth. 2010; 104(2): 167-74[DOI][PubMed]
  • 23. Hogue CW, Fucetola R, Hershey T, Freedland K, Davila-Roman VG, Goate AM, et al. Risk factors for neurocognitive dysfunction after cardiac surgery in postmenopausal women. Ann Thorac Surg. 2008; 86(2): 511-6[DOI][PubMed]
  • 24. Bhaskar SB, Bajwa SJ. From pre-operative comorbidities to post-operative cognitive dysfunction: The challenging face of geriatric anaesthesia. Indian J Anaesth. 2014; 58(3): 248-50[DOI][PubMed]
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