Anesthesiology and Pain Medicine

Published by: Kowsar

Prophylactic Effects of Doxapram, Ketamine and Meperidine in Postoperative Shivering

Bahman Hasannasab 1 , Nadia Banihashem 1 , * and Arash Khoshbakht 1
Authors Information
1 Anesthesiology Department, Babol University of Medical Sciences, Babol, Iran
Article information
  • Anesthesiology and Pain Medicine: February 01, 2016, 6 (1); e27515
  • Published Online: January 10, 2016
  • Article Type: Research Article
  • Received: April 12, 2015
  • Revised: June 6, 2015
  • Accepted: September 1, 2015
  • DOI: 10.5812/aapm.27515

To Cite: Hasannasab B, Banihashem N, Khoshbakht A. Prophylactic Effects of Doxapram, Ketamine and Meperidine in Postoperative Shivering, Anesth Pain Med. 2016 ; 6(1):e27515. doi: 10.5812/aapm.27515.

Copyright © 2016, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Elvan EG, Oc B, Uzun S, Karabulut E, Coskun F, Aypar U. Dexmedetomidine and postoperative shivering in patients undergoing elective abdominal hysterectomy. Eur J Anaesthesiol. 2008; 25(5): 357-64[DOI][PubMed]
  • 2. Sessler DI. Miller's Anesthesia. 2005; : 1533-52
  • 3. Kim YA, Kweon TD, Kim M, Lee HI, Lee YJ, Lee KY. Comparison of meperidine and nefopam for prevention of shivering during spinal anesthesia. Korean J Anesthesiol. 2013; 64(3): 229-33[DOI][PubMed]
  • 4. Kose EA, Dal D, Akinci SB, Saricaoglu F, Aypar U. The efficacy of ketamine for the treatment of postoperative shivering. Anesth Analg. 2008; 106(1): 120-2[DOI][PubMed]
  • 5. De Witte J, Sessler DI. Perioperative shivering: physiology and pharmacology. Anesthesiology. 2002; 96(2): 467-84[PubMed]
  • 6. Iqbal A, Ahmed A, Rudra A, Wankhede RG, Sengupta S, Das T, et al. Prophylactic granisetron vs pethidine for the prevention of postoperative shivering: a randomized control trial. Indian J Anaesth. 2009; 53(3): 330-4[PubMed]
  • 7. Dal D, Kose A, Honca M, Akinci SB, Basgul E, Aypar U. Efficacy of prophylactic ketamine in preventing postoperative shivering. Br J Anaesth. 2005; 95(2): 189-92[DOI][PubMed]
  • 8. Sagir O, Gulhas N, Toprak H, Yucel A, Begec Z, Ersoy O. Control of shivering during regional anaesthesia: prophylactic ketamine and granisetron. Acta Anaesthesiol Scand. 2007; 51(1): 44-9[DOI][PubMed]
  • 9. Gecaj-Gashi A, Hashimi M, Sada F, Salihu S, Terziqi H. Prophylactic ketamine reduces incidence of postanaesthetic shivering. Niger J Med. 2010; 19(3): 267-70[PubMed]
  • 10. Kose EA, Honca M, Dal D, Akinci SB, Aypar U. Prophylactic ketamine to prevent shivering in parturients undergoing Cesarean delivery during spinal anesthesia. J Clin Anesth. 2013; 25(4): 275-80[DOI][PubMed]
  • 11. Bhukal I, Solanki SL, Kumar S, Jain A. Pre-induction low dose pethidine does not decrease incidence of postoperative shivering in laparoscopic gynecological surgeries. J Anaesthesiol Clin Pharmacol. 2011; 27(3): 349-53[DOI][PubMed]
  • 12. Wason R, Jain N, Gupta P, Gogia AR. Randomized double-blind comparison of prophylactic ketamine, clonidine and tramadol for the control of shivering under neuraxial anaesthesia. Indian J Anaesth. 2012; 56(4): 370-5[DOI][PubMed]
  • 13. Gangopadhyay S, Gupta K, Acharjee S, Nayak SK, Dawn S, Piplai G. Ketamine, tramadol and pethidine in prophylaxis of shivering during spinal anaesthesia. J Anaesthesiol Clin Pharmacol. 2010; 26(1): 59
  • 14. Wrench IJ, Singh P, Dennis AR, Mahajan RP, Crossley AW. The minimum effective doses of pethidine and doxapram in the treatment of post-anaesthetic shivering. Anaesthesia. 1997; 52(1): 32-6[PubMed]
  • 15. Shrestha AB. Comparative study on effectiveness of doxapram and pethidine for postanaesthetic shivering. JNMA J Nepal Med Assoc. 2009; 48(174): 116-20[PubMed]
  • 16. Komatsu R, Sengupta P, Cherynak G, Wadhwa A, Sessler DI, Liu J, et al. Doxapram only slightly reduces the shivering threshold in healthy volunteers. Anesth Analg. 2005; 101(5): 1368-73[DOI][PubMed]
  • 17. Ayatollahi V, Hajiesmaeili MR, Behdad S, Gholipur M, Abbasi HR. Comparison of prophylactic use of meperidine and two low doses of ketamine for prevention of post-anesthetic shivering: A randomized double-blind placebo controlled trial. J Res Med Sci. 2011; 16(10): 1340-6[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments