Anesthesiology and Pain Medicine

Published by: Kowsar

Interventional Therapies for Chronic Low Back Pain: A Focused Review (Efficacy and Outcomes)

Vikram B. Patel 1 , * , Ronald Wasserman 2 and Farnad Imani 3
Authors Information
1 Phoenix Interventional Center for Advanced Learning, Algonquin, Illinois, USA
2 Back and Pain Center, University of Michigan, Ann Arbor, Michigan, USA
3 Pain Research Center, Iran University of Medical Sciences, Tehran, Iran
Article information
  • Anesthesiology and Pain Medicine: August 01, 2015, 5 (4); e29716
  • Published Online: August 22, 2015
  • Article Type: Review Article
  • Received: May 4, 2015
  • Accepted: May 17, 2015
  • DOI: 10.5812/aapm.29716

To Cite: Patel V B, Wasserman R, Imani F. Interventional Therapies for Chronic Low Back Pain: A Focused Review (Efficacy and Outcomes), Anesth Pain Med. 2015 ; 5(4):e29716. doi: 10.5812/aapm.29716.

Copyright © 2015, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Relevant Anatomy
3. Etiology of Low Back Pain
4. Interventions
5. Conclusions
  • 1. Williams KA, Gonzalez-Fernandez M, Hamzehzadeh S, Wilkinson I, Erdek MA, Plunkett A, et al. A multi-center analysis evaluating factors associated with spinal cord stimulation outcome in chronic pain patients. Pain Med. 2011; 12(8): 1142-53[DOI][PubMed]
  • 2. van Dulmen S, Sluijs E, van Dijk L, de Ridder D, Heerdink R, Bensing J. Patient adherence to medical treatment: a review of reviews. BMC Health Serv Res. 2007; 7: 55[DOI][PubMed]
  • 3. Manchikanti L, Cash KA, Pampati V, McManus CD, Damron KS. Evaluation of fluoroscopically guided caudal epidural injections. Pain Physician. 2004; 7(1): 81-92[PubMed]
  • 4. Hansen HC. Is fluoroscopy necessary for sacroiliac joint injections? Pain Physician. 2003; 6(2): 155-8[PubMed]
  • 5. Jasper JF. Role of digital subtraction fluoroscopic imaging in detecting intravascular injections. Pain Physician. 2003; 6(3): 369-72[PubMed]
  • 6. Jasper JF. Is digital subtraction flouroscopy a useful tool for the interventional pain physician? Pain Physician. 2002; 5(1): 36-9[PubMed]
  • 7. Gandini R, Chiocchi M, Maresca L, Pipitone V, Messina M, Simonetti G. Chronic contained rupture of an abdominal aortic aneurysm: from diagnosis to endovascular resolution. Cardiovasc Intervent Radiol. 2008; 31 Suppl 2-6[DOI][PubMed]
  • 8. Hasegawa K, Katsuta E, Iwata N, Aoyagi H, Yoshida T, Takahata T, et al. [A case of locally advanced pancreas cancer effectively treated by multidisciplinary strategy]. Gan To Kagaku Ryoho. 2011; 38(12): 2152-4[PubMed]
  • 9. Patel SN, Kettner NW. Abdominal aortic aneurysm presenting as back pain to a chiropractic clinic: a case report. J Manipulative Physiol Ther. 2006; 29(5): 409 e1-7[DOI][PubMed]
  • 10. Lavelle ED, Lavelle W, Smith HS. Myofascial trigger points. Med Clin North Am. 2007; 91(2): 229-39[DOI][PubMed]
  • 11. Alvarez DJ, Rockwell PG. Trigger points: diagnosis and management. Am Fam Physician. 2002; 65(4): 653-60[PubMed]
  • 12. Soares A, Andriolo RB, Atallah AN, da Silva EM. Botulinum toxin for myofascial pain syndromes in adults. Cochrane Database Syst Rev. 2012; 4[DOI][PubMed]
  • 13. Jabbari B. Treatment of chronic low back pain with botulinum neurotoxins. Curr Pain Headache Rep. 2007; 11(5): 352-8[PubMed]
  • 14. Manchikanti KN, Pampati V, Damron KS, McManus CD. A double-blind, controlled evaluation of the value of sarapin in neural blockade. Pain Physician. 2004; 7(1): 59-62[PubMed]
  • 15. Cotchett MP, Landorf KB, Munteanu SE. Effectiveness of dry needling and injections of myofascial trigger points associated with plantar heel pain: a systematic review. J Foot Ankle Res. 2010; 3: 18[DOI][PubMed]
  • 16. Ay S, Evcik D, Tur BS. Comparison of injection methods in myofascial pain syndrome: a randomized controlled trial. Clin Rheumatol. 2010; 29(1): 19-23[DOI][PubMed]
  • 17. Mathis JM. Epidural steroid injections. Neuroimaging Clin N Am. 2010; 20(2): 193-202[DOI][PubMed]
  • 18. Manchikanti L, Cash KA, McManus CD, Pampati V, Benyamin R. Fluoroscopic lumbar interlaminar epidural injections in managing chronic lumbar axial or discogenic pain. J Pain Res. 2012; 5: 301-11[DOI][PubMed]
  • 19. Cannon DT, Aprill CN. Lumbosacral epidural steroid injections. Arch Phys Med Rehabil. 2000; 81(3 Suppl 1)-98[PubMed]
  • 20. Manchikanti L, Cash KA, McManus CD, Pampati V. Fluoroscopic caudal epidural injections in managing chronic axial low back pain without disc herniation, radiculitis, or facet joint pain. J Pain Res. 2012; 5: 381-90[DOI][PubMed]
  • 21. Kranz PG, Raduazo P, Gray L, Kilani RK, Hoang JK. CT fluoroscopy-guided cervical interlaminar steroid injections: safety, technique, and radiation dose parameters. AJNR Am J Neuroradiol. 2012; 33(7): 1221-4[DOI][PubMed]
  • 22. Kim H, Lee SH, Kim MH. Multislice CT fluoroscopy-assisted cervical transforaminal injection of steroids: technical note. J Spinal Disord Tech. 2007; 20(6): 456-61[PubMed]
  • 23. Manchikanti L, Malla Y, Wargo BW, Cash KA, Pampati V, Fellows B. A prospective evaluation of complications of 10,000 fluoroscopically directed epidural injections. Pain Physician. 2012; 15(2): 131-40[PubMed]
  • 24. Manchikanti L, Singh V, Cash KA, Pampati V, Falco FJE. The Role of Fluoroscopic Interlaminar Epidural Injections in Managing Chronic Pain of Lumbar Disc Herniation or Radiculitis: A Randomized, Double-Blind Trial. Pain Pract. 2013; 13(7): 547-58[DOI]
  • 25. Benyamin RM, Manchikanti L, Parr AT, Diwan S, Singh V, Falco FJ, et al. The effectiveness of lumbar interlaminar epidural injections in managing chronic low back and lower extremity pain. Pain Physician. 2012; 15(4)-404[PubMed]
  • 26. Stitz MY, Sommer HM. Accuracy of blind versus fluoroscopically guided caudal epidural injection. Spine (Phila Pa 1976). 1999; 24(13): 1371-6[PubMed]
  • 27. Sekiguchi M, Yabuki S, Satoh K, Kikuchi S. An anatomic study of the sacral hiatus: a basis for successful caudal epidural block. Clin J Pain. 2004; 20(1): 51-4[PubMed]
  • 28. Nagar SK. A study of sacral hiatus in dry human sacra. J Anat Soc India. 2004; 53(2): 18-21
  • 29. Kumar V, Nayak SR, Potu BK, Pulakunta T. Sacral hiatus in relation to low back pain in south Indian population. Bratisl Lek Listy. 2009; 110(7): 436-41[PubMed]
  • 30. Cleary M, Keating C, Poynton AR. The flow patterns of caudal epidural in upper lumbar spinal pathology. Eur Spine J. 2011; 20(5): 804-7[DOI][PubMed]
  • 31. Rabinovitch DL, Peliowski A, Furlan AD. Influence of lumbar epidural injection volume on pain relief for radicular leg pain and/or low back pain. Spine J. 2009; 9(6): 509-17[DOI][PubMed]
  • 32. Botwin KP, Gruber RD, Bouchlas CG, Torres-Ramos FM, Hanna A, Rittenberg J, et al. Complications of fluoroscopically guided caudal epidural injections. Am J Phys Med Rehabil. 2001; 80(6): 416-24[PubMed]
  • 33. Parr AT, Manchikanti L, Hameed H, Conn A, Manchikanti KN, Benyamin RM, et al. Caudal epidural injections in the management of chronic low back pain: a systematic appraisal of the literature. Pain Physician. 2012; 15(3)-98[PubMed]
  • 34. Conn A, Buenaventura RM, Datta S, Abdi S, Diwan S. Systematic review of caudal epidural injections in the management of chronic low back pain. Pain Physician. 2009; 12(1): 109-35[PubMed]
  • 35. Vad VB, Bhat AL, Lutz GE, Cammisa F. Transforaminal epidural steroid injections in lumbosacral radiculopathy: a prospective randomized study. Spine (Phila Pa 1976). 2002; 27(1): 11-6[PubMed]
  • 36. Benny B, Azari P. The efficacy of lumbosacral transforaminal epidural steroid injections: a comprehensive literature review. J Back Musculoskelet Rehabil. 2011; 24(2): 67-76[DOI][PubMed]
  • 37. Schaufele MK, Hatch L, Jones W. Interlaminar versus transforaminal epidural injections for the treatment of symptomatic lumbar intervertebral disc herniations. Pain Physician. 2006; 9(4): 361-6[PubMed]
  • 38. Manchikanti L, Cash KA, Pampati V, Damron KS, McManus CD. Evaluation of lumbar transforaminal epidural injections with needle placement and contrast flow patterns: a prospective, descriptive report. Pain Physician. 2004; 7(2): 217-23[PubMed]
  • 39. Jasper JF. Lumbar retrodiscal transforaminal injection. Pain Physician. 2007; 10(3): 501-10[PubMed]
  • 40. Park KD, Lee JH, Park Y. Injectate Volumes Needed to Reach Specific Landmarks and Contrast Pattern in Kambin's Triangle Approach with Spinal Stenosis. Ann Rehabil Med. 2012; 36(4): 480-7[DOI][PubMed]
  • 41. Park JW, Nam HS, Cho SK, Jung HJ, Lee BJ, Park Y. Kambin's Triangle Approach of Lumbar Transforaminal Epidural Injection with Spinal Stenosis. Ann Rehabil Med. 2011; 35(6): 833-43[DOI][PubMed]
  • 42. Choi YK, Barbella JD. Evaluation of epidurographic contrast patterns with fluoroscopic-guided lumbar interlaminar ventral epidural injection. Pain Pract. 2009; 9(4): 275-81[DOI][PubMed]
  • 43. Levi D. Intradiscal flow during a transforaminal epidural steroid injection. Pain Med. 2010; 11(5): 716-8[DOI][PubMed]
  • 44. Moon HS, Shin BC, Im HS, Song BH, Cha YD. Inadvertent discogram during transforaminal epidural injection in patients with lumbar disc herniation -A report of 2 cases. Korean J Anesthesiol. 2010; 58(1): 104-8[DOI][PubMed]
  • 45. Lutz GE, Vad VB, Wisneski RJ. Fluoroscopic transforaminal lumbar epidural steroids: an outcome study. Arch Phys Med Rehabil. 1998; 79(11): 1362-6[PubMed]
  • 46. Manchikanti L. Transforaminal lumbar epidural steroid injections. Pain Physician. 2000; 3(4): 374-98[PubMed]
  • 47. Boswell MV, Colson JD, Sehgal N, Dunbar EE, Epter R. A systematic review of therapeutic facet joint interventions in chronic spinal pain. Pain Physician. 2007; 10(1): 229-53[PubMed]
  • 48. Issack PS, Cunningham ME, Pumberger M, Hughes AP, Cammisa FJ. Degenerative lumbar spinal stenosis: evaluation and management. J Am Acad Orthop Surg. 2012; 20(8): 527-35[DOI][PubMed]
  • 49. Manchikanti L, Singh V, Cash KA, Pampati V, Datta S. Preliminary results of a randomized, equivalence trial of fluoroscopic caudal epidural injections in managing chronic low back pain: Part 3--Post surgery syndrome. Pain Physician. 2008; 11(6): 817-31[PubMed]
  • 50. Datta S, Lee M, Falco FJ, Bryce DA, Hayek SM. Systematic assessment of diagnostic accuracy and therapeutic utility of lumbar facet joint interventions. Pain Physician. 2009; 12(2): 437-60[PubMed]
  • 51. Cohen SP, Raja SN. Pathogenesis, diagnosis, and treatment of lumbar zygapophysial (facet) joint pain. Anesthesiology. 2007; 106(3): 591-614[PubMed]
  • 52. Bogduk N. The innervation of the lumbar spine. Spine (Phila Pa 1976). 1983; 8(3): 286-93[PubMed]
  • 53. Stojanovic MP, Zhou Y, Hord ED, Vallejo R, Cohen SP. Single needle approach for multiple medial branch blocks: a new technique. Clin J Pain. 2003; 19(2): 134-7[PubMed]
  • 54. Stojanovic MP, Dey D, Hord ED, Zhou Y, Cohen SP. A prospective crossover comparison study of the single-needle and multiple-needle techniques for facet-joint medial branch block. Reg Anesth Pain Med. 2005; 30(5): 484-90[DOI][PubMed]
  • 55. Greher M, Kirchmair L, Enna B, Kovacs P, Gustorff B, Kapral S, et al. Ultrasound-guided lumbar facet nerve block: accuracy of a new technique confirmed by computed tomography. Anesthesiology. 2004; 101(5): 1195-200[PubMed]
  • 56. Dreyfuss P, Schwarzer AC, Lau P, Bogduk N. Specificity of lumbar medial branch and L5 dorsal ramus blocks. A computed tomography study. Spine (Phila Pa 1976). 1997; 22(8): 895-902[PubMed]
  • 57. Manchikanti L, Singh V, Pampati V. Are diagnostic lumbar medial branch blocks valid? Results of 2-year follow-up. Pain Physician. 2003; 6(2): 147-53[PubMed]
  • 58. Sehgal N, Dunbar EE, Shah RV, Colson J. Systematic review of diagnostic utility of facet (zygapophysial) joint injections in chronic spinal pain: an update. Pain Physician. 2007; 10(1): 213-28[PubMed]
  • 59. Falco FJ, Manchikanti L, Datta S, Sehgal N, Geffert S, Onyewu O, et al. An update of the effectiveness of therapeutic lumbar facet joint interventions. Pain Physician. 2012; 15(6)-53[PubMed]
  • 60. Dory MA. Arthrography of the lumbar facet joints. Radiology. 1981; 140(1): 23-7[DOI][PubMed]
  • 61. McCormick CC, Taylor JR, Twomey LT. Facet joint arthrography in lumbar spondylolysis: anatomic basis for spread of contrast medium. Radiology. 1989; 171(1): 193-6[DOI][PubMed]
  • 62. Schleifer J, Fenzl G, Wolf A, Diehl K. [Treatment of lumbar facet joint syndrome by CT-guided infiltration of the intervertebral joints]. Radiologe. 1994; 34(11): 666-70[PubMed]
  • 63. Yun DH, Kim HS, Yoo SD, Kim DH, Chon JM, Choi SH, et al. Efficacy of ultrasonography-guided injections in patients with facet syndrome of the low lumbar spine. Ann Rehabil Med. 2012; 36(1): 66-71[DOI][PubMed]
  • 64. Civelek E, Cansever T, Kabatas S, Kircelli A, Yilmaz C, Musluman M, et al. Comparison of effectiveness of facet joint injection and radiofrequency denervation in chronic low back pain. Turk Neurosurg. 2012; 22(2): 200-6[DOI][PubMed]
  • 65. Shealy CN. Percutaneous radiofrequency denervation of spinal facets. Treatment for chronic back pain and sciatica. J Neurosurg. 1975; 43(4): 448-51[DOI][PubMed]
  • 66. Shealy CN. Facet denervation in the management of back and sciatic pain. Clin Orthop Relat Res. 1976; (115): 157-64[PubMed]
  • 67. Lau P, Mercer S, Govind J, Bogduk N. The surgical anatomy of lumbar medial branch neurotomy (facet denervation). Pain Med. 2004; 5(3): 289-98[DOI][PubMed]
  • 68. Dobrogowski J, Wrzosek A, Wordliczek J. Radiofrequency denervation with or without addition of pentoxifylline or methylprednisolone for chronic lumbar zygapophysial joint pain. Pharmacol Rep. 2005; 57(4): 475-80[PubMed]
  • 69. Demazumder D, Mirotznik MS, Schwartzman D. Comparison of irrigated electrode designs for radiofrequency ablation of myocardium. J Interv Card Electrophysiol. 2001; 5(4): 391-400[PubMed]
  • 70. Bogduk N, Macintosh J, Marsland A. Technical limitations to the efficacy of radiofrequency neurotomy for spinal pain. Neurosurgery. 1987; 20(4): 529-35[PubMed]
  • 71. Buijs EJ, van Wijk RM, Geurts JW, Weeseman RR, Stolker RJ, Groen GG. Radiofrequency lumbar facet denervation: a comparative study of the reproducibility of lesion size after 2 current radiofrequency techniques. Reg Anesth Pain Med. 2004; 29(5): 400-7[PubMed]
  • 72. Gofeld M, Faclier G. Radiofrequency denervation of the lumbar zygapophysial joints--targeting the best practice. Pain Med. 2008; 9(2): 204-11[DOI][PubMed]
  • 73. Leclaire R, Fortin L, Lambert R, Bergeron YM, Rossignol M. Radiofrequency facet joint denervation in the treatment of low back pain: a placebo-controlled clinical trial to assess efficacy. Spine (Phila Pa 1976). 2001; 26(13): 1411-6[PubMed]
  • 74. van Kleef M, Barendse GA, Kessels A, Voets HM, Weber WE, de Lange S. Randomized trial of radiofrequency lumbar facet denervation for chronic low back pain. Spine (Phila Pa 1976). 1999; 24(18): 1937-42[PubMed]
  • 75. Klessinger S. Radiofrequency neurotomy for treatment of low back pain in patients with minor degenerative spondylolisthesis. Pain Physician. 2012; 15(1)-8[PubMed]
  • 76. Klessinger S. Zygapophysial joint pain in post lumbar surgery syndrome. The efficacy of medial branch blocks and radiofrequency neurotomy. Pain Med. 2013; 14(3): 374-7[DOI][PubMed]
  • 77. Forst SL, Wheeler MT, Fortin JD, Vilensky JA. The sacroiliac joint: anatomy, physiology and clinical significance. Pain Physician. 2006; 9(1): 61-7[PubMed]
  • 78. Nakagawa T. [Study on the distribution of nerve filaments over the iliosacral joint and its adjacent regio n in the Japanese]. Nihon Seikeigeka Gakkai Zasshi. 1966; 40(4): 419-30[PubMed]
  • 79. Vanelderen P, Szadek K, Cohen SP, De Witte J, Lataster A, Patijn J, et al. 13. Sacroiliac joint pain. Pain Pract. 2010; 10(5): 470-8[DOI][PubMed]
  • 80. Fortin JD, Tolchin RB. Sacroiliac arthrograms and post-arthrography computerized tomography. Pain Physician. 2003; 6(3): 287-90[PubMed]
  • 81. Klauser A, De Zordo T, Feuchtner G, Sogner P, Schirmer M, Gruber J, et al. Feasibility of ultrasound-guided sacroiliac joint injection considering sonoanatomic landmarks at two different levels in cadavers and patients. Arthritis Rheum. 2008; 59(11): 1618-24[DOI][PubMed]
  • 82. Migliore A, Bizzi E, Massafra U, Vacca F, Martin-Martin LS, Granata M, et al. A new technical contribution for ultrasound-guided injections of sacro-iliac joints. Eur Rev Med Pharmacol Sci. 2010; 14(5): 465-9[PubMed]
  • 83. Hartung W, Ross CJ, Straub R, Feuerbach S, Scholmerich J, Fleck M, et al. Ultrasound-guided sacroiliac joint injection in patients with established sacroiliitis: precise IA injection verified by MRI scanning does not predict clinical outcome. Rheumatology (Oxford). 2010; 49(8): 1479-82[DOI][PubMed]
  • 84. Hansen H, Manchikanti L, Simopoulos TT, Christo PJ, Gupta S, Smith HS, et al. A systematic evaluation of the therapeutic effectiveness of sacroiliac joint interventions. Pain Physician. 2012; 15(3)-78[PubMed]
  • 85. Simopoulos TT, Manchikanti L, Singh V, Gupta S, Hameed H, Diwan S, et al. A systematic evaluation of prevalence and diagnostic accuracy of sacroiliac joint interventions. Pain Physician. 2012; 15(3)-44[PubMed]
  • 86. Rupert MP, Lee M, Manchikanti L, Datta S, Cohen SP. Evaluation of sacroiliac joint interventions: a systematic appraisal of the literature. Pain Physician. 2009; 12(2): 399-418[PubMed]
  • 87. Kapural L, Nageeb F, Kapural M, Cata JP, Narouze S, Mekhail N. Cooled radiofrequency system for the treatment of chronic pain from sacroiliitis: the first case-series. Pain Pract. 2008; 8(5): 348-54[DOI][PubMed]
  • 88. Stelzer W, Aiglesberger M, Stelzer D, Stelzer V. Use of cooled radiofrequency lateral branch neurotomy for the treatment of sacroiliac joint-mediated low back pain: a large case series. Pain Med. 2013; 14(1): 29-35[DOI][PubMed]
  • 89. Patel N, Gross A, Brown L, Gekht G. A randomized, placebo-controlled study to assess the efficacy of lateral branch neurotomy for chronic sacroiliac joint pain. Pain Med. 2012; 13(3): 383-98[DOI][PubMed]
  • 90. Ferrante FM, King LF, Roche EA, Kim PS, Aranda M, Delaney LR, et al. Radiofrequency sacroiliac joint denervation for sacroiliac syndrome. Reg Anesth Pain Med. 2001; 26(2): 137-42[DOI][PubMed]
  • 91. Burnham RS, Yasui Y. An alternate method of radiofrequency neurotomy of the sacroiliac joint: a pilot study of the effect on pain, function, and satisfaction. Reg Anesth Pain Med. 2007; 32(1): 12-9[DOI][PubMed]
  • 92. Vallejo R, Benyamin RM, Kramer J, Stanton G, Joseph NJ. Pulsed radiofrequency denervation for the treatment of sacroiliac joint syndrome. Pain Med. 2006; 7(5): 429-34[DOI][PubMed]
  • 93. Sacroiliac joint radiofrequency denervation using the Neurotherm Simplicity III system - a case series. 6th World Congress
  • 94. Videman T, Nurminen M. The occurrence of anular tears and their relation to lifetime back pain history: a cadaveric study using barium sulfate discography. Spine (Phila Pa 1976). 2004; 29(23): 2668-76[PubMed]
  • 95. Palmgren T, Gronblad M, Virri J, Kaapa E, Karaharju E. An immunohistochemical study of nerve structures in the anulus fibrosus of human normal lumbar intervertebral discs. Spine (Phila Pa 1976). 1999; 24(20): 2075-9[PubMed]
  • 96. Peng B, Wu W, Hou S, Li P, Zhang C, Yang Y. The pathogenesis of discogenic low back pain. J Bone Joint Surg Br. 2005; 87(1): 62-7[PubMed]
  • 97. Stout A. Discography. Phys Med Rehabil Clin N Am. 2010; 21(4): 859-67[DOI][PubMed]
  • 98. Berg S, Isberg B, Josephson A, Fallman M. The impact of discography on the surgical decision in patients with chronic low back pain. Spine J. 2012; 12(4): 283-91[DOI][PubMed]
  • 99. Carragee EJ, Alamin TF, Miller J, Grafe M. Provocative discography in volunteer subjects with mild persistent low back pain. Spine J. 2002; 2(1): 25-34[PubMed]
  • 100. Carragee EJ. Is lumbar discography a determinate of discogenic low back pain: provocative discography reconsidered. Curr Rev Pain. 2000; 4(4): 301-8[PubMed]
  • 101. Zucherman J, Derby R, Hsu K, Picetti G, Kaiser J, Schofferman J, et al. Normal magnetic resonance imaging with abnormal discography. Spine (Phila Pa 1976). 1988; 13(12): 1355-9[PubMed]
  • 102. Peng B, Hou S, Wu W, Zhang C, Yang Y. The pathogenesis and clinical significance of a high-intensity zone (HIZ) of lumbar intervertebral disc on MR imaging in the patient with discogenic low back pain. Eur Spine J. 2006; 15(5): 583-7[DOI][PubMed]
  • 103. Vanharanta H, Sachs BL, Spivey MA, Guyer RD, Hochschuler SH, Rashbaum RF, et al. The relationship of pain provocation to lumbar disc deterioration as seen by CT/discography. Spine (Phila Pa 1976). 1987; 12(3): 295-8[PubMed]
  • 104. Sachs BL, Vanharanta H, Spivey MA, Guyer RD, Videman T, Rashbaum RF, et al. Dallas discogram description. A new classification of CT/discography in low-back disorders. Spine (Phila Pa 1976). 1987; 12(3): 287-94[PubMed]
  • 105. Nachemson AL. Disc pressure measurements. Spine (Phila Pa 1976). 1981; 6(1): 93-7[PubMed]
  • 106. Lee SH, Derby R, Chen Y, Seo KS, Kim MJ. In vitro measurement of pressure in intervertebral discs and annulus fibrosus with and without annular tears during discography. Spine J. 2004; 4(6): 614-8[DOI][PubMed]
  • 107. Quinnell RC, Stockdale HR, Harmon B. Pressure standardized lumbar discography. Br J Radiol. 1980; 53(635): 1031-6[DOI][PubMed]
  • 108. Derby R, Howard MW, Grant JM, Lettice JJ, Van Peteghem PK, Ryan DP. The ability of pressure-controlled discography to predict surgical and nonsurgical outcomes. Spine (Phila Pa 1976). 1999; 24(4): 364-71[PubMed]
  • 109. Phillips H, Glazebrook JJ, Timothy J. Cauda equina compression post lumbar discography. Acta Neurochir (Wien). 2012; 154(6): 1033-6[DOI][PubMed]
  • 110. Poynton AR, Hinman A, Lutz G, Farmer JC. Discography-induced acute lumbar disc herniation: a report of five cases. J Spinal Disord Tech. 2005; 18(2): 188-92[PubMed]
  • 111. Lopez WO, Vialle EN, Anillo CC, Guzmao M, Vialle LR. Clinical and radiological association with positive lumbar discography in patients with chronic low back pain. Evid Based Spine Care J. 2012; 3(1): 27-34[DOI][PubMed]
  • 112. Derby R, Kim BJ, Lee SH, Chen Y, Seo KS, Aprill C. Comparison of discographic findings in asymptomatic subject discs and the negative discs of chronic LBP patients: can discography distinguish asymptomatic discs among morphologically abnormal discs? Spine J. 2005; 5(4): 389-94[DOI][PubMed]
  • 113. Manchikanti L, Glaser SE, Wolfer L, Derby R, Cohen SP. Systematic review of lumbar discography as a diagnostic test for chronic low back pain. Pain Physician. 2009; 12(3): 541-59[PubMed]
  • 114. Fritsch EW, Heisel J, Rupp S. The failed back surgery syndrome: reasons, intraoperative findings, and long-term results: a report of 182 operative treatments. Spine (Phila Pa 1976). 1996; 21(5): 626-33[PubMed]
  • 115. Deyo RA, Gray DT, Kreuter W, Mirza S, Martin BI. United States trends in lumbar fusion surgery for degenerative conditions. Spine (Phila Pa 1976). 2005; 30(12): 1441-5[PubMed]
  • 116. Katz JN. Lumbar spinal fusion. Surgical rates, costs, and complications. Spine (Phila Pa 1976). 1995; 20(24 Suppl): 78S-83S[PubMed]
  • 117. Atlas SJ, Keller RB, Wu YA, Deyo RA, Singer DE. Long-term outcomes of surgical and nonsurgical management of sciatica secondary to a lumbar disc herniation: 10 year results from the maine lumbar spine study. Spine (Phila Pa 1976). 2005; 30(8): 927-35[PubMed]
  • 118. Hirsch JA, Singh V, Falco FJ, Benyamin RM, Manchikanti L. Automated percutaneous lumbar discectomy for the contained herniated lumbar disc: a systematic assessment of evidence. Pain Physician. 2009; 12(3): 601-20[PubMed]
  • 119. Singh V, Benyamin RM, Datta S, Falco FJ, Helm S2, Manchikanti L. Systematic review of percutaneous lumbar mechanical disc decompression utilizing Dekompressor. Pain Physician. 2009; 12(3): 589-99[PubMed]
  • 120. Manchikanti L, Derby R, Benyamin RM, Helm S, Hirsch JA. A systematic review of mechanical lumbar disc decompression with nucleoplasty. Pain Physician. 2009; 12(3): 561-72[PubMed]
  • 121. Lierz P, Alo KM, Felleiter P. Percutaneous lumbar discectomy using the Dekompressor system under CT-control. Pain Pract. 2009; 9(3): 216-20[DOI][PubMed]
  • 122. Singh V, Piryani C, Liao K. Evaluation of percutaneous disc decompression using coblation in chronic back pain with or without leg pain. Pain Physician. 2003; 6(3): 273-80[PubMed]
  • 123. Zhu H, Zhou XZ, Cheng MH, Shen YX, Dong QR. The efficacy of coblation nucleoplasty for protrusion of lumbar intervertebral disc at a two-year follow-up. Int Orthop. 2011; 35(11): 1677-82[DOI][PubMed]
  • 124. Singh V, Manchikanti L, Benyamin RM, Helm S, Hirsch JA. Percutaneous lumbar laser disc decompression: a systematic review of current evidence. Pain Physician. 2009; 12(3): 573-88[PubMed]
  • 125. Zhao XL, Fu ZJ, Xu YG, Zhao XJ, Song WG, Zheng H. Treatment of lumbar intervertebral disc herniation using C-arm fluoroscopy guided target percutaneous laser disc decompression. Photomed Laser Surg. 2012; 30(2): 92-5[DOI][PubMed]
  • 126. Wegener B, Rieskamp K, Buttner A, Habiyambere V, von Schultze-Pellangahr C, Schaffer V, et al. Experimental evaluation of the risk of extradiscal thermal damage in intradiscal electrothermal therapy (IDET). Pain Physician. 2012; 15(1)[PubMed]
  • 127. Saal JA, Saal JS. Intradiscal electrothermal treatment for chronic discogenic low back pain: a prospective outcome study with minimum 1-year follow-up. Spine (Phila Pa 1976). 2000; 25(20): 2622-7[PubMed]
  • 128. Freeman BJ, Fraser RD, Cain CM, Hall DJ, Chapple DC. A randomized, double-blind, controlled trial: intradiscal electrothermal therapy versus placebo for the treatment of chronic discogenic low back pain. Spine (Phila Pa 1976). 2005; 30(21): 2369-77[PubMed]
  • 129. Pauza KJ, Howell S, Dreyfuss P, Peloza JH, Dawson K, Bogduk N. A randomized, placebo-controlled trial of intradiscal electrothermal therapy for the treatment of discogenic low back pain. Spine J. 2004; 4(1): 27-35[PubMed]
  • 130. Kvarstein G, Mawe L, Indahl A, Hol PK, Tennoe B, Digernes R, et al. A randomized double-blind controlled trial of intra-annular radiofrequency thermal disc therapy--a 12-month follow-up. Pain. 2009; 145(3): 279-86[DOI][PubMed]
  • 131. Kapural L, Mekhail N. Novel intradiscal biacuplasty (IDB) for the treatment of lumbar discogenic pain. Pain Pract. 2007; 7(2): 130-4[DOI][PubMed]
  • 132. Kapural L, Ng A, Dalton J, Mascha E, Kapural M, de la Garza M, et al. Intervertebral disc biacuplasty for the treatment of lumbar discogenic pain: results of a six-month follow-up. Pain Med. 2008; 9(1): 60-7[DOI][PubMed]
  • 133. Kapural L, Vrooman B, Sarwar S, Krizanac-Bengez L, Rauck R, Gilmore C, et al. A randomized, placebo-controlled trial of transdiscal radiofrequency, biacuplasty for treatment of discogenic lower back pain. Pain Med. 2013; 14(3): 362-73[DOI][PubMed]
  • 134. Cheng J, Pope JE, Dalton JE, Cheng O, Bensitel A. Comparative outcomes of cooled versus traditional radiofrequency ablation of the lateral branches for sacroiliac joint pain. Clin J Pain. 2013; 29(2): 132-7[DOI][PubMed]
  • 135. Helm Ii S, Deer TR, Manchikanti L, Datta S, Chopra P, Singh V, et al. Effectiveness of thermal annular procedures in treating discogenic low back pain. Pain Physician. 2012; 15(3)-304[PubMed]
  • 136. 2015;
  • 137. Gupta A, Martindale T, Christo PJ. Intrathecal catheter granuloma associated with continuous sufentanil infusion. Pain Med. 2010; 11(6): 847-52[DOI][PubMed]
  • 138. Cabbell KL, Taren JA, Sagher O. Spinal cord compression by catheter granulomas in high-dose intrathecal morphine therapy: case report. Neurosurgery. 1998; 42(5): 1176-80[PubMed]
  • 139. Abejon D, del Saz JM, Ley L, Sanchez MR, del Pozo C. [Spinal granuloma in a patient receiving a spinal infusion of morphine and clonidine]. Rev Esp Anestesiol Reanim. 2009; 56(6): 380-4[PubMed]
  • 140. Bejjani GK, Karim NO, Tzortzidis F. Intrathecal granuloma after implantation of a morphine pump: case report and review of the literature. Surg Neurol. 1997; 48(3): 288-91[PubMed]
  • 141. Miele VJ, Price K, Bloomfield S, Hogg J, Bailes J. Intrathecal morphine therapy related granulomas: two case reports. W V Med J. 2006; 102(5): 16-8[PubMed]
  • 142. Patel VB, Manchikanti L, Singh V, Schultz DM, Hayek SM, Smith HS. Systematic review of intrathecal infusion systems for long-term management of chronic non-cancer pain. Pain Physician. 2009; 12(2): 345-60[PubMed]
  • 143. Deer T, Chapple I, Classen A, Javery K, Stoker V, Tonder L, et al. Intrathecal drug delivery for treatment of chronic low back pain: report from the National Outcomes Registry for Low Back Pain. Pain Med. 2004; 5(1): 6-13[PubMed]
  • 144. Lara NJ, Teixeira MJ, Fonoff ET. Long term intrathecal infusion of opiates for treatment of failed back surgery syndrome. Acta Neurochir Suppl. 2011; 108: 41-7[DOI][PubMed]
  • 145. Anderson VC, Burchiel KJ. A prospective study of long-term intrathecal morphine in the management of chronic nonmalignant pain. Neurosurgery. 1999; 44(2): 289-300[PubMed]
  • 146. Kumar K, Kelly M, Pirlot T. Continuous intrathecal morphine treatment for chronic pain of nonmalignant etiology: long-term benefits and efficacy. Surg Neurol. 2001; 55(2): 79-86[PubMed]
  • 147. Rauck RL, Wallace MS, Burton AW, Kapural L, North JM. Intrathecal ziconotide for neuropathic pain: a review. Pain Pract. 2009; 9(5): 327-37[DOI][PubMed]
  • 148. Lynch SS, Cheng CM, Yee JL. Intrathecal ziconotide for refractory chronic pain. Ann Pharmacother. 2006; 40(7-8): 1293-300[DOI][PubMed]
  • 149. Pope JE, Deer TR. Ziconotide: a clinical update and pharmacologic review. Expert Opin Pharmacother. 2013; 14(7): 957-66[DOI][PubMed]
  • 150. Bala MM, Riemsma RP, Nixon J, Kleijnen J. Systematic review of the (cost-)effectiveness of spinal cord stimulation for people with failed back surgery syndrome. Clin J Pain. 2008; 24(9): 741-56[DOI][PubMed]
  • 151. Simpson EL, Duenas A, Holmes MW, Papaioannou D, Chilcott J. Spinal cord stimulation for chronic pain of neuropathic or ischaemic origin: systematic review and economic evaluation. Health Technol Assess. 2009; 13(17)-154[DOI][PubMed]
  • 152. Hollingworth W, Turner JA, Welton NJ, Comstock BA, Deyo RA. Costs and cost-effectiveness of spinal cord stimulation (SCS) for failed back surgery syndrome: an observational study in a workers' compensation population. Spine (Phila Pa 1976). 2011; 36(24): 2076-83[DOI][PubMed]
  • 153. Rutten S, Komp M, Godolias G. [Spinal cord stimulation (SCS) using an 8-pole electrode and double-electrode system as minimally invasive therapy of the post-discotomy and post-fusion syndrome--prospective study results in 34 patients]. Z Orthop Ihre Grenzgeb. 2002; 140(6): 626-31[DOI][PubMed]
  • 154. Rainov NG, Heidecke V, Burkert W. Short test-period spinal cord stimulation for failed back surgery syndrome. Minim Invasive Neurosurg. 1996; 39(2): 41-4[DOI][PubMed]
  • 155. Sarubbo S, Latini F, Tugnoli V, Quatrale R, Granieri E, Cavallo MA. Spinal anesthesia and minimal invasive laminotomy for paddle electrode placement in spinal cord stimulation: technical report and clinical results at long-term followup. ScientificWorldJournal. 2012; 2012: 201053[DOI][PubMed]
  • 156. Deer T, Bowman R, Schocket SM, Kim C, Ranson M, Amirdelfan K, et al. The prospective evaluation of safety and success of a new method of introducing percutaneous paddle leads and complex arrays with an epidural access system. Neuromodulation. 2012; 15(1): 21-9[DOI][PubMed]
  • 157. Loge D, De Coster O, Washburn S. Technological innovation in spinal cord stimulation: use of a newly developed delivery device for introduction of spinal cord stimulation leads. Neuromodulation. 2012; 15(4): 392-401[DOI][PubMed]
  • 158. Kinfe TM, Schu S, Quack FJ, Wille C, Vesper J. Percutaneous implanted paddle lead for spinal cord stimulation: technical considerations and long-term follow-up. Neuromodulation. 2012; 15(4): 402-7[DOI][PubMed]
  • 159. Epstein LJ, Palmieri M. Managing chronic pain with spinal cord stimulation. Mt Sinai J Med. 2012; 79(1): 123-32[DOI][PubMed]
  • 160. Ohnmeiss DD, Rashbaum RF. Patient satisfaction with spinal cord stimulation for predominant complaints of chronic, intractable low back pain. Spine J. 2001; 1(5): 358-63[PubMed]
  • 161. Burchiel KJ, Anderson VC, Brown FD, Fessler RG, Friedman WA, Pelofsky S, et al. Prospective, multicenter study of spinal cord stimulation for relief of chronic back and extremity pain. Spine (Phila Pa 1976). 1996; 21(23): 2786-94[PubMed]
  • 162. de Vos CC, Dijkstra C, Lenders MW, Holsheimer J. Spinal cord stimulation with hybrid lead relieves pain in low back and legs. Neuromodulation. 2012; 15(2): 118-23[DOI][PubMed]
  • 163. Taylor RJ, Taylor RS. Spinal cord stimulation for failed back surgery syndrome: a decision-analytic model and cost-effectiveness analysis. Int J Technol Assess Health Care. 2005; 21(3): 351-8[PubMed]
  • 164. North RB, Kidd DH, Farrokhi F, Piantadosi SA. Spinal cord stimulation versus repeated lumbosacral spine surgery for chronic pain: a randomized, controlled trial. Neurosurgery. 2005; 56(1): 98-106[PubMed]
  • 165. North RB, Kidd DH, Piantadosi S. Spinal cord stimulation versus reoperation for failed back surgery syndrome: a prospective, randomized study design. Acta Neurochir Suppl. 1995; 64: 106-8[PubMed]
  • 166. Frey ME, Manchikanti L, Benyamin RM, Schultz DM, Smith HS, Cohen SP. Spinal cord stimulation for patients with failed back surgery syndrome: a systematic review. Pain Physician. 2009; 12(2): 379-97[PubMed]
  • 167. Sharan A, Cameron T, Barolat G. Evolving patterns of spinal cord stimulation in patients implanted for intractable low back and leg pain. Neuromodulation. 2002; 5(3): 167-79[DOI][PubMed]
  • 168. Abejon D, Deer T, Verrills P. Subcutaneous stimulation: how to assess optimal implantation depth. Neuromodulation. 2011; 14(4): 343-7[DOI][PubMed]
  • 169. Verrills P, Vivian D, Mitchell B, Barnard A. Peripheral nerve field stimulation for chronic pain: 100 cases and review of the literature. Pain Med. 2011; 12(9): 1395-405[DOI][PubMed]
  • 170. Bernstein CA, Paicius RM, Barkow SH, Lempert-Cohen C. Spinal cord stimulation in conjunction with peripheral nerve field stimulation for the treatment of low back and leg pain: a case series. Neuromodulation. 2008; 11(2): 116-23[DOI][PubMed]
  • 171. Mironer YE, Hutcheson JK, Satterthwaite JR, LaTourette PC. Prospective, two-part study of the interaction between spinal cord stimulation and peripheral nerve field stimulation in patients with low back pain: development of a new spinal-peripheral neurostimulation method. Neuromodulation. 2011; 14(2): 151-4[DOI][PubMed]
  • 172. Reverberi C, Dario A, Barolat G. Spinal cord stimulation (SCS) in conjunction with peripheral nerve field stimulation (PNfS) for the treatment of complex pain in failed back surgery syndrome (FBSS). Neuromodulation. 2013; 16(1): 78-82[DOI][PubMed]
  • 173. Yakovlev AE, Resch BE, Yakovleva VE. Peripheral nerve field stimulation in the treatment of postlaminectomy syndrome after multilevel spinal surgeries. Neuromodulation. 2011; 14(6): 534-8[DOI][PubMed]
  • 174. Burgher AH, Huntoon MA, Turley TW, Doust MW, Stearns LJ. Subcutaneous peripheral nerve stimulation with inter-lead stimulation for axial neck and low back pain: case series and review of the literature. Neuromodulation. 2012; 15(2): 100-6[DOI][PubMed]
  • 175. Cuellar JM, Alataris K, Walker A, Yeomans DC, Antognini JF. Effect of high-frequency alternating current on spinal afferent nociceptive transmission. Neuromodulation. 2013; 16(4): 318-27[DOI][PubMed]
  • 176. Van Buyten JP, Al-Kaisy A, Smet I, Palmisani S, Smith T. High-frequency spinal cord stimulation for the treatment of chronic back pain patients: results of a prospective multicenter European clinical study. Neuromodulation. 2013; 16(1): 59-65[DOI][PubMed]
  • 177. Tiede J, Brown L, Gekht G, Vallejo R, Yearwood T, Morgan D. Novel spinal cord stimulation parameters in patients with predominant back pain. Neuromodulation. 2013; 16(4): 370-5[DOI][PubMed]
  • 178. Perruchoud C, Eldabe S, Batterham AM, Madzinga G, Brookes M, Durrer A, et al. Analgesic efficacy of high-frequency spinal cord stimulation: a randomized double-blind placebo-controlled study. Neuromodulation. 2013; 16(4): 363-9[DOI][PubMed]
  • 179. Kelsey JL, White A3. Epidemiology and impact of low-back pain. Spine (Phila Pa 1976). 1980; 5(2): 133-42[PubMed]
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