Anesthesiology and Pain Medicine

Published by: Kowsar

Emergency Corrective Surgery of Congenital Diaphragmatic Hernia With Pulmonary Hypertension: Prolonged Use of Dexmedetomidine as a Pharmacologic Adjunct

Badri Prasad Das 1 , * , Anil Prasad Singh 1 and Ram Badan Singh 1
Authors Information
1 Department of Anesthesia, Pain Medicine and Critical Care, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
Article information
  • Anesthesiology and Pain Medicine: June 01, 2016, 6 (3); e31880
  • Published Online: May 6, 2016
  • Article Type: Case Report
  • Received: August 31, 2015
  • Revised: October 8, 2015
  • Accepted: November 14, 2015
  • DOI: 10.5812/aapm.31880

To Cite: Das B P, Singh A P, Singh R B. Emergency Corrective Surgery of Congenital Diaphragmatic Hernia With Pulmonary Hypertension: Prolonged Use of Dexmedetomidine as a Pharmacologic Adjunct, Anesth Pain Med. 2016 ; 6(3):e31880. doi: 10.5812/aapm.31880.

Copyright © 2016, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Case Presentation
3. Discussion
  • 1. Ackerman KG, Pober BR. Congenital diaphragmatic hernia and pulmonary hypoplasia: new insights from developmental biology and genetics. Am J Med Genet C Semin Med Genet. 2007; 145C(2): 105-8[DOI][PubMed]
  • 2. van den Hout L, Reiss I, Felix JF, Hop WC, Lally PA, Lally KP, et al. Risk factors for chronic lung disease and mortality in newborns with congenital diaphragmatic hernia. Neonatology. 2010; 98(4): 370-80[DOI][PubMed]
  • 3. Logan JW, Cotten CM, Goldberg RN, Clark RH. Mechanical ventilation strategies in the management of congenital diaphragmatic hernia. Semin Pediatr Surg. 2007; 16(2): 115-25[DOI][PubMed]
  • 4. Scholz J, Tonner PH. Alpha2-adrenoceptor agonists in anaesthesia: a new paradigm. Curr Opin Anaesthesiol. 2000; 13(4): 437-42[PubMed]
  • 5. Tobias JD. Dexmedetomidine: applications in pediatric critical care and pediatric anesthesiology. Pediatr Crit Care Med. 2007; 8(2): 115-31[DOI][PubMed]
  • 6. Ebert TJ, Hall JE, Barney JA, Uhrich TD, Colinco MD. The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology. 2000; 93(2): 382-94[PubMed]
  • 7. Bloor BC, Ward DS, Belleville JP, Maze M. Effects of intravenous dexmedetomidine in humans. II. Hemodynamic changes. Anesthesiology. 1992; 77(6): 1134-42[PubMed]
  • 8. But AK, Ozgul U, Erdil F, Gulhas N, Toprak HI, Durmus M, et al. The effects of pre-operative dexmedetomidine infusion on hemodynamics in patients with pulmonary hypertension undergoing mitral valve replacement surgery. Acta Anaesthesiol Scand. 2006; 50(10): 1207-12[DOI][PubMed]
  • 9. Lazol JP, Lichtenstein SE, Jooste EH, Shiderly D, Kudchadker NA, Tatum GH, et al. Effect of dexmedetomidine on pulmonary artery pressure after congenital cardiac surgery: A pilot study. Pediatr Crit Care Med. 2010; 11(5): 589-92[DOI][PubMed]
  • 10. Nathan AT, Marino BS, Hanna B, Nicolson SC. Novel use of dexmedetomidine in a patient with pulmonary hypertension. Paediatr Anaesth. 2008; 18(8): 782-4[DOI][PubMed]
  • 11. Munro HM, Felix DE, Nykanen DG. Dexmedetomidine/ketamine for diagnostic cardiac catheterization in a child with idiopathic pulmonary hypertension. J Clin Anesth. 2009; 21(6): 435-8[DOI][PubMed]
  • 12. Shinohara H, Hirota K, Sato M, Kakuyama M, Fukuda K. Monitored anesthesia care with dexmedetomidine of a patient with severe pulmonary arterial hypertension for inguinal hernioplasty. J Anesth. 2010; 24(4): 611-3[DOI][PubMed]
  • 13. Buck ML, Willson DF. Use of dexmedetomidine in the pediatric intensive care unit. Pharmacotherapy. 2008; 28(1): 51-7[DOI][PubMed]
  • 14. Reiter PD, Pietras M, Dobyns EL. Prolonged dexmedetomidine infusions in critically ill infants and children. Indian Pediatr. 2009; 46(9): 767-73[PubMed]
  • 15. Faritus SZ, Khazaee-Koohpar M, Ziyaeifard M, Mehrabanian MJ. Oral Dexmedetomidine Versus Midazolam as Anesthetic Premedication in Children Undergoing Congenital Heart Surgery. Anesth Pain Med. 2015; 5(3)[DOI][PubMed]
  • 16. Tobias JD, Goble TJ, Bates G, Anderson JT, Hoernschemeyer DG. Effects of dexmedetomidine on intraoperative motor and somatosensory evoked potential monitoring during spinal surgery in adolescents. Paediatr Anaesth. 2008; 18(11): 1082-8[DOI][PubMed]
  • 17. Tokuhira N, Atagi K, Shimaoka H, Ujiro A, Otsuka Y, Ramsay M. Dexmedetomidine sedation for pediatric post-Fontan procedure patients. Pediatr Crit Care Med. 2009; 10(2): 207-12[DOI][PubMed]
  • 18. Chrysostomou C, Di Filippo S, Manrique AM, Schmitt CG, Orr RA, Casta A, et al. Use of dexmedetomidine in children after cardiac and thoracic surgery. Pediatr Crit Care Med. 2006; 7(2): 126-31[DOI][PubMed]
  • 19. Mirkheshti A, Saadatniaki A, Salimi A, Manafi Rasi A, Memary E, Yahyaei H. Effects of dexmedetomidine versus ketorolac as local anesthetic adjuvants on the onset and duration of infraclavicular brachial plexus block. Anesth Pain Med. 2014; 4(3)[DOI][PubMed]
  • 20. Solanki SL, Goyal VK. Neuraxial dexmedetomidine: wonder drug or simply harmful. Anesth Pain Med. 2015; 5(2)[DOI][PubMed]
  • 21. Bharati S, Pal A, Biswas C, Biswas R. Incidence of cardiac arrest increases with the indiscriminate use of dexmedetomidine: a case series and review of published case reports. Acta Anaesthesiol Taiwan. 2011; 49(4): 165-7[DOI][PubMed]
  • 22. Shehabi Y, Botha JA, Ernest D, Freebairn RC, Reade M, Roberts BL, et al. Clinical application, the use of dexmedetomidine in intensive care sedation. Crit Care Shock. 2010; 13: 40-50
  • 23. Chrysostomou C, Schulman SR, Herrera Castellanos M, Cofer BE, Mitra S, da Rocha MG, et al. A phase II/III, multicenter, safety, efficacy, and pharmacokinetic study of dexmedetomidine in preterm and term neonates. J Pediatr. 2014; 164(2): 276-82 e1-3[DOI][PubMed]
  • 24. Tobias JD. Dexmedetomidine: Are There Going to be Issues with Prolonged Administration? J Pediatr Pharmacol Ther. 2010; 15(1): 4-9[PubMed]
  • 25. Anand VG. Sedation in intensive care unit: Is Dexmedetomidine the best choice? Int J Crit Illn Inj Sci. 2012; 2(1): 3-5[DOI][PubMed]
  • 26. Fitzgerald M, Beggs S. The neurobiology of pain: developmental aspects. Neuroscientist. 2001; 7(3): 246-57[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments