Anesthesiology and Pain Medicine

Published by: Kowsar

The Role of Caffeine in Pain Management: A Brief Literature Review

Alireza Baratloo 1 , Alaleh Rouhipour 2 , Mohammad Mehdi Forouzanfar 1 , Saeed Safari 1 , Marzieh Amiri 3 and Ahmed Negida 4 , *
Authors Information
1 Department of Emergency Medicine, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Pediatric Specialist, Tehran, Iran
3 Department of Emergency Medicine, Shahid Beheshti Hospital, Guilan University of Medical Sciences, Anzali, Iran
4 Student Research Unit, Zagazig University, Zagazig, Egypt
Article information
  • Anesthesiology and Pain Medicine: June 01, 2016, 6 (3); e33193
  • Published Online: March 26, 2016
  • Article Type: Review Article
  • Received: September 15, 2015
  • Revised: October 17, 2015
  • Accepted: October 20, 2015
  • DOI: 10.5812/aapm.33193

To Cite: Baratloo A, Rouhipour A, Forouzanfar M M, Safari S, Amiri M, et al. The Role of Caffeine in Pain Management: A Brief Literature Review, Anesth Pain Med. 2016 ; 6(3):e33193. doi: 10.5812/aapm.33193.

Copyright © 2016, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Results
4. Conclusions
  • 1. Nehlig A, Daval JL, Debry G. Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res Brain Res Rev. 1992; 17(2): 139-70[PubMed]
  • 2. Waldvogel SR. Caffeine--a drug with a surprise. Angew Chem Int Ed Engl. 2003; 42(6): 604-5[DOI][PubMed]
  • 3. Xu J. Coffee. Journal of Agricultural & Food Information. 2003; 5(3): 79-86[DOI]
  • 4. Fredholm BB. Notes on the history of caffeine use. Handb Exp Pharmacol. 2011; (200): 1-9[DOI][PubMed]
  • 5. Ennis D. The Effects of Caffeine on Health: The Benefits Outweigh the Risks. 2014;
  • 6. Glade MJ. Caffeine-Not just a stimulant. Nutrition. 2010; 26(10): 932-8[DOI][PubMed]
  • 7. Imani F, Rahimzadeh P, Faiz SH. Comparison of the efficacy of adding clonidine, chlorpromazine, promethazine, and midazolam to morphine pumps in postoperative pain control of addicted patients. Anesth Pain Med. 2011; 1(1): 10-4[DOI][PubMed]
  • 8. Sluijter ME, Imani F. Evolution and mode of action of pulsed radiofrequency. Anesth Pain Med. 2013; 2(4): 139-41[DOI][PubMed]
  • 9. Alimian M, Imani F, Hassani V, Rahimzadeh P, Sharifian M, Safari S. Effects of single-dose pregabalin on postoperative pain in dacryocystorhinostomy surgery. Anesth Pain Med. 2012; 2(2): 72-6[DOI][PubMed]
  • 10. Imani F, Rahimzadeh P. Gabapentinoids: gabapentin and pregabalin for postoperative pain management. Anesth Pain Med. 2012; 2(2): 52-3[DOI][PubMed]
  • 11. Sawynok J. Methylxanthines and pain. Handb Exp Pharmacol. 2011; (200): 311-29[DOI][PubMed]
  • 12. Zylka MJ. Pain-relieving prospects for adenosine receptors and ectonucleotidases. Trends Mol Med. 2011; 17(4): 188-96[DOI][PubMed]
  • 13. Zylka MJ. Needling adenosine receptors for pain relief. Nat Neurosci. 2010; 13(7): 783-4[DOI][PubMed]
  • 14. Sawynok J. Adenosine. 2013; : 343-60[DOI]
  • 15. Sawynok J. Adenosine receptor activation and nociception. Eur J Pharmacol. 1998; 347(1): 1-11[PubMed]
  • 16. Latini S, Pedata F. Adenosine in the central nervous system: release mechanisms and extracellular concentrations. J Neurochem. 2001; 79(3): 463-84[PubMed]
  • 17. Rogers NL, Dinges DF. Caffeine: implications for alertness in athletes. Clin Sports Med. 2005; 24(2)-13[DOI][PubMed]
  • 18. Sollevi A. Adenosine for pain control. Acta Anaesthesiol Scand Suppl. 1997; 110: 135-6[PubMed]
  • 19. Astorino TA, Terzi MN, Roberson DW, Burnett TR. Effect of caffeine intake on pain perception during high-intensity exercise. Int J Sport Nutr Exerc Metab. 2011; 21(1): 27-32[PubMed]
  • 20. Benowitz NL. Clinical pharmacology of caffeine. Annu Rev Med. 1990; 41: 277-88[DOI][PubMed]
  • 21. Carvey CE, Thompson LA, Mahoney CR. Sleep Deprivation, Stimulant Medications, and Cognition. 2012; : 93
  • 22. Derry CJ, Derry S, Moore RA. Caffeine as an analgesic adjuvant for acute pain in adults. The Cochrane Library. 2014; [DOI]
  • 23. Laska EM, Sunshine A, Mueller F, Elvers WB, Siegel C, Rubin A. Caffeine as an analgesic adjuvant. JAMA. 1984; 251(13): 1711-8[PubMed]
  • 24. Nikolajsen L, Haroutiunian S. [Caffeine as adjuvant analgeticum for treating acute pain]. Ugeskr Laeger. 2013; 175(42): 2486-8[PubMed]
  • 25. Derry CJ, Derry S, Moore RA. Caffeine as an analgesic adjuvant for acute pain in adults. Cochrane Database Syst Rev. 2012; 3[DOI][PubMed]
  • 26. Suh SY, Choi YS, Oh SC, Kim YS, Cho K, Bae WK, et al. Caffeine as an adjuvant therapy to opioids in cancer pain: a randomized, double-blind, placebo-controlled trial. J Pain Symptom Manage. 2013; 46(4): 474-82[DOI][PubMed]
  • 27. Raskin NH. The hypnic headache syndrome. Headache. 1988; 28(8): 534-6[PubMed]
  • 28. Lanteri-Minet M, Donnet A. Hypnic headache. Curr Pain Headache Rep. 2010; 14(4): 309-15[DOI][PubMed]
  • 29. Lanteri-Minet M. Hypnic headache. Headache. 2014; 54(9): 1556-9[DOI][PubMed]
  • 30. Holle D, Obermann M. Hypnic headache and caffeine. Expert Rev Neurother. 2012; 12(9): 1125-32[DOI][PubMed]
  • 31. Evers S, Goadsby PJ. Hypnic headache: clinical features, pathophysiology, and treatment. Neurology. 2003; 60(6): 905-9[PubMed]
  • 32. Liang JF, Wang SJ. Hypnic headache: a review of clinical features, therapeutic options and outcomes. Cephalalgia. 2014; 34(10): 795-805[DOI][PubMed]
  • 33. Dodick DW, Mosek AC, Campbell JK. The hypnic ("alarm clock") headache syndrome. Cephalalgia. 1998; 18(3): 152-6[PubMed]
  • 34. Bezov D, Lipton RB, Ashina S. Post-dural puncture headache: part I diagnosis, epidemiology, etiology, and pathophysiology. Headache. 2010; 50(7): 1144-52[DOI][PubMed]
  • 35. Ragab A, Facharzt KN. Caffeine, Is it effective for prevention of postdural puncture headache in young adult patients? Egypt J Anaesthesia. 2014; 30(2): 181-6[DOI]
  • 36. Halker RB, Demaerschalk BM, Wellik KE, Wingerchuk DM, Rubin DI, Crum BA, et al. Caffeine for the prevention and treatment of postdural puncture headache: debunking the myth. Neurologist. 2007; 13(5): 323-7[DOI][PubMed]
  • 37. Jarvis AP, Greenawalt JW, Fagraeus L. Intravenous caffeine for postdural puncture headache. Anesth Analg. 1986; 65(3): 316-7[PubMed]
  • 38. Camann WR, Murray RS, Mushlin PS, Lambert DH. Effects of oral caffeine on postdural puncture headache. A double-blind, placebo-controlled trial. Anesth Analg. 1990; 70(2): 181-4[PubMed]
  • 39. Yucel A, Ozyalcin S, Talu GK, Yucel EC, Erdine S. Intravenous administration of caffeine sodium benzoate for postdural puncture headache. Reg Anesth Pain Med. 1999; 24(1): 51-4[PubMed]
  • 40. Straube A, Neudert C, Glas M, Bruning R, Padovan CS. [The so-called spontaneous low CSF pressure pressure syndrome. Case results indicating a disturbance in CSF/blood volume regulation]. Nervenarzt. 2004; 75(12): 1194-9[DOI][PubMed]
  • 41. Lin W, Geiderman J. Myth: fluids, bed rest, and caffeine are effective in preventing and treating patients with post-lumbar puncture headache. West J Med. 2002; 176(1): 69-70[PubMed]
  • 42. Baratloo A, Negida A, El Ashal G. Intravenous Caffeine for the Treatment of Acute Migraine: A Pilot Study. J Caffeine Res. 2015; 5(3): 125-9[DOI]
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