Anesthesiology and Pain Medicine

Published by: Kowsar

Multi-Modal Preemptive Analgesia With Pregabalin, Acetaminophen, Naproxen, and Dextromethorphan in Radical Neck Dissection Surgery: A Randomized Clinical Trial

Hamid Reza Amiri 1 , Mojtaba Mirzaei 1 , Mohammad Taghi Beig Mohammadi 1 and Farhad Tavakoli 1 , *
Authors Information
1 Department of Anesthesiology and Critical Care, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
Article information
  • Anesthesiology and Pain Medicine: August 01, 2016, 6 (4); e33526
  • Published Online: July 2, 2016
  • Article Type: Research Article
  • Received: November 13, 2015
  • Revised: April 4, 2016
  • Accepted: May 28, 2016
  • DOI: 10.5812/aapm.33526

To Cite: Amiri H R, Mirzaei M, Beig Mohammadi M T, Tavakoli F. Multi-Modal Preemptive Analgesia With Pregabalin, Acetaminophen, Naproxen, and Dextromethorphan in Radical Neck Dissection Surgery: A Randomized Clinical Trial, Anesth Pain Med. 2016 ; 6(4):e33526. doi: 10.5812/aapm.33526.

Abstract
Copyright © 2016, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
References
  • 1. Brunicardi FC. Schwartz's principles of surgery. 2005;
  • 2. Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet. 2006; 367(9522): 1618-25[DOI][PubMed]
  • 3. Macrae WA. Chronic pain after surgery. Br J Anaesth. 2001; 87(1): 88-98[PubMed]
  • 4. Dashputra AV, Badwaik RT. Utilization of analgesics in perioperative cases of teaching hospital. Inter J Med Pharma Sci. 2013; 3(6): 14-9
  • 5. Apfelbaum JL, Chen C, Mehta SS, Gan TJ. Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg. 2003; 97(2): 534-40[PubMed]
  • 6. Gan TJ, Habib AS, Miller TE, White W, Apfelbaum JL. Incidence, patient satisfaction, and perceptions of post-surgical pain: results from a US national survey. Curr Med Res Opin. 2014; 30(1): 149-60[DOI][PubMed]
  • 7. Hariharan S, Moseley H, Kumar A, Raju S. The effect of preemptive analgesia in postoperative pain relief--a prospective double-blind randomized study. Pain Med. 2009; 10(1): 49-53[DOI][PubMed]
  • 8. Carr DB, Goudas LC. Acute pain. Lancet. 1999; 353(9169): 2051-8[DOI][PubMed]
  • 9. Julius D, Basbaum AI. Molecular mechanisms of nociception. Nature. 2001; 413(6852): 203-10[DOI][PubMed]
  • 10. Gandhi K, Viscusi E. Multimodal pain management techniques in hip and knee arthroplasty. J New York School Regional Anesthesia. 2009; 13: 1-10
  • 11. Anderson BJ. Paracetamol (Acetaminophen): mechanisms of action. Paediatr Anaesth. 2008; 18(10): 915-21[DOI][PubMed]
  • 12. Graham GG, Davies MJ, Day RO, Mohamudally A, Scott KF. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Inflammopharmacology. 2013; 21(3): 201-32[DOI][PubMed]
  • 13. Kis B, Snipes JA, Busija DW. Acetaminophen and the cyclooxygenase-3 puzzle: sorting out facts, fictions, and uncertainties. J Pharmacol Exp Ther. 2005; 315(1): 1-7[DOI][PubMed]
  • 14. Maneuf YP, Gonzalez MI, Sutton KS, Chung FZ, Pinnock RD, Lee K. Cellular and molecular action of the putative GABA-mimetic, gabapentin. Cell Mol Life Sci. 2003; 60(4): 742-50[PubMed]
  • 15. Weinbroum AA, Gorodetzky A, Nirkin A, Kollender Y, Bickels J, Marouani N, et al. Dextromethorphan for the reduction of immediate and late postoperative pain and morphine consumption in orthopedic oncology patients: a randomized, placebo-controlled, double-blind study. Cancer. 2002; 95(5): 1164-70[DOI][PubMed]
  • 16. Suski M, Bujak-Gizycka B, Madej J, Kacka K, Dobrogowski J, Woron J, et al. Co-administration of dextromethorphan and morphine: reduction of post-operative pain and lack of influence on morphine metabolism. Basic Clin Pharmacol Toxicol. 2010; 107(2): 680-4[DOI][PubMed]
  • 17. Helmy SA, Bali A. The effect of the preemptive use of the NMDA receptor antagonist dextromethorphan on postoperative analgesic requirements. Anesth Analg. 2001; 92(3): 739-44[PubMed]
  • 18. Imani F, Faiz HR, Sedaghat M, Hajiashrafi M. Effects of adding ketamine to fentanyl plus acetaminophen on postoperative pain by patient controlled analgesia in abdominal surgery. Anesth Pain Med. 2014; 4(1): 12162[DOI][PubMed]
  • 19. Rafiei MR, Aghadavoudi O, Rezvani M, Poorqasemian M. Evaluation of preemptive analgesia with dextromethorphan gurgling in patients undergoing tonsillectomy. J Rese Med Sci. 2012; 17
  • 20. Alimian M, Imani F, Faiz SH, Pournajafian A, Navadegi SF, Safari S. Effect of oral pregabalin premedication on post-operative pain in laparoscopic gastric bypass surgery. Anesth Pain Med. 2012; 2(1): 12-6[DOI][PubMed]
  • 21. Pandey CK, Navkar DV, Giri PJ, Raza M, Behari S, Singh RB, et al. Evaluation of the optimal preemptive dose of gabapentin for postoperative pain relief after lumbar diskectomy: a randomized, double-blind, placebo-controlled study. J Neurosurg Anesthesiol. 2005; 17(2): 65-8[PubMed]
  • 22. Alimian M, Imani F, Hassani V, Rahimzadeh P, Sharifian M, Safari S. Effects of single-dose pregabalin on postoperative pain in dacryocystorhinostomy surgery. Anesth Pain Med. 2012; 2(2): 72-6[DOI][PubMed]
  • 23. Dierking G, Duedahl TH, Rasmussen ML, Fomsgaard JS, Moiniche S, Romsing J, et al. Effects of gabapentin on postoperative morphine consumption and pain after abdominal hysterectomy: a randomized, double-blind trial. Acta Anaesthesiol Scand. 2004; 48(3): 322-7[DOI][PubMed]
  • 24. Mikkelsen S, Hilsted KL, Andersen PJ, Hjortso NC, Enggaard TP, Jorgensen DG, et al. The effect of gabapentin on post-operative pain following tonsillectomy in adults. Acta Anaesthesiol Scand. 2006; 50(7): 809-15[DOI][PubMed]
  • 25. Fassoulaki A, Stamatakis E, Petropoulos G, Siafaka I, Hassiakos D, Sarantopoulos C. Gabapentin attenuates late but not acute pain after abdominal hysterectomy. Eur J Anaesthesiol. 2006; 23(2): 136-41[DOI][PubMed]
  • 26. Imani F, Rahimzadeh P. Gabapentinoids: gabapentin and pregabalin for postoperative pain management. Anesth Pain Med. 2012; 2(2): 52-3[DOI][PubMed]
  • 27. Khalili G, Janghorbani M, Saryazdi H, Emaminejad A. Effect of preemptive and preventive acetaminophen on postoperative pain score: a randomized, double-blind trial of patients undergoing lower extremity surgery. J Clin Anesth. 2013; 25(3): 188-92[DOI][PubMed]
  • 28. Kashefi P, Honarmand A, Safavi M. Effects of preemptive analgesia with celecoxib or acetaminophen on postoperative pain relief following lower extremity orthopedic surgery. Adv Biomed Res. 2012; 1: 66[DOI][PubMed]
  • 29. Gilron I, Orr E, Tu D, O'Neill JP, Zamora JE, Bell AC. A placebo-controlled randomized clinical trial of perioperative administration of gabapentin, rofecoxib and their combination for spontaneous and movement-evoked pain after abdominal hysterectomy. Pain. 2005; 113(1-2): 191-200[DOI][PubMed]
  • 30. Ong CK, Seymour RA, Lirk P, Merry AF. Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain. Anesth Analg. 2010; 110(4): 1170-9[DOI][PubMed]
  • 31. Wong I, St John-Green C, Walker SM. Opioid-sparing effects of perioperative paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs) in children. Paediatr Anaesth. 2013; 23(6): 475-95[DOI][PubMed]
  • 32. Hurley RW, Chatterjea D, Rose Feng M, Taylor CP, Hammond DL. Gabapentin and pregabalin can interact synergistically with naproxen to produce antihyperalgesia. Anesthesiology. 2002; 97(5): 1263-73[PubMed]
  • 33. Kemp J, Despres O, Dufour A. Unreliability of the visual analog scale in experimental pain assessment: a sensitivity and evoked potentials study. Pain Physician. 2012; 15(5): 693-9[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments