Anesthesiology and Pain Medicine

Published by: Kowsar

Comparing Clonidine and Lidocaine on Attenuation of Hemodynamic Responses to Laryngoscopy and Tracheal Intubation in Controlled Hypertensive Patients: A Randomized, Double-Blinded Clinical Trial

Sussan Soltani Mohammadi 1 , * , Alireza Maziar 1 and Alireza Saliminia 1
Authors Information
1 Department of Anesthesiology, Critical Care and Pain Medicine, Dr Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Article information
  • Anesthesiology and Pain Medicine: April 01, 2016, 6 (2); e34271
  • Published Online: March 27, 2016
  • Article Type: Research Article
  • Received: November 4, 2015
  • Revised: December 7, 2015
  • Accepted: December 27, 2015
  • DOI: 10.5812/aapm.34271

To Cite: Soltani Mohammadi S, Maziar A, Saliminia A. Comparing Clonidine and Lidocaine on Attenuation of Hemodynamic Responses to Laryngoscopy and Tracheal Intubation in Controlled Hypertensive Patients: A Randomized, Double-Blinded Clinical Trial, Anesth Pain Med. 2016 ; 6(2):e34271. doi: 10.5812/aapm.34271.

Copyright © 2016, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Imani F, Alebouyeh MR, Taghipour Anvari Z, Faiz SH. Use of remifentanil and alfentanil in endotracheal intubation: a comparative study. Anesth Pain Med. 2011; 1(2): 61-5[DOI][PubMed]
  • 2. Taghipour Anvari Z, Afshar-Fereydouniyan N, Imani F, Sakhaei M, Alijani B, Mohseni M. Effect of clonidine premedication on blood loss in spine surgery. Anesth Pain Med. 2012; 1(4): 252-6[DOI][PubMed]
  • 3. Sameenakousar M, Srinivasan KV. Comparison of fentanyl and clonidine for attenuation of the haemodynamic response to laryngocopy and endotracheal intubation. J Clin Diagn Res. 2013; 7(1): 106-11[DOI][PubMed]
  • 4. Hassani V, Movassaghi G, Goodarzi V, Safari S. Comparison of fentanyl and fentanyl plus lidocaine on attenuation of hemodynamic responses to tracheal intubation in controlled hypertensive patients undergoing general anesthesia. Anesth Pain Med. 2013; 2(3): 115-8[DOI][PubMed]
  • 5. Rahimzadeh P, Faiz SH, Alebouyeh MR. Effects of premedication with metoprolol on bleeding and induced hypotension in nasal surgery. Anesth Pain Med. 2012; 1(3): 157-61[DOI][PubMed]
  • 6. Salihoglu Z, Demiroluk S, Kose Y. Comparison of effects of remifentanil, alfentanil and fentanyl on cardiovascular responses to tracheal intubation in morbidly obese patients. Eur J Anaesthesiol. 2002; 19(2): 125-8[PubMed]
  • 7. Abrams JT, Horrow JC, Bennett JA, Van Riper DF, Storella RJ. Upper airway closure: a primary source of difficult ventilation with sufentanil induction of anesthesia. Anesth Analg. 1996; 83(3): 629-32[PubMed]
  • 8. Farzi F, Haddadi S, Ebrahimpour N, Atrkar Roshan Z, Faghih Habibi A, Mirmansouri A, et al. A Survey on the Effect of Oral Gabapentin on Hemodynamic Changes During Direct Laryngoscopy and Tracheal Intubation and Intraoperative Bleeding in Patients Undergoing Septorhinoplasty. Anesth Pain Med. 2015; 5(5)[DOI][PubMed]
  • 9. Joo HS, Salasidis GC, Kataoka MT, Mazer CD, Naik VN, Chen RB, et al. Comparison of bolus remifentanil versus bolus fentanyl for induction of anesthesia and tracheal intubation in patients with cardiac disease. J Cardiothorac Vasc Anesth. 2004; 18(3): 263-8[PubMed]
  • 10. Ko SH, Kim DC, Han YJ, Song HS. Small-dose fentanyl: optimal time of injection for blunting the circulatory responses to tracheal intubation. Anesth Analg. 1998; 86(3): 658-61[PubMed]
  • 11. Kimura A, Yamakage M, Chen X, Kamada Y, Namiki A. Use of the fibreoptic stylet scope (Styletscope) reduces the hemodynamic response to intubation in normotensive and hypertensive patients. Can J Anaesth. 2001; 48(9): 919-23[DOI][PubMed]
  • 12. Kitamura T, Yamada Y, Chinzei M, Du HL, Hanaoka K. Attenuation of haemodynamic responses to tracheal intubation by the styletscope. Br J Anaesth. 2001; 86(2): 275-7[PubMed]
  • 13. Kim WY, Lee YS, Ok SJ, Chang MS, Kim JH, Park YC, et al. Lidocaine does not prevent bispectral index increases in response to endotracheal intubation. Anesth Analg. 2006; 102(1): 156-9[DOI][PubMed]
  • 14. Aouad MT, Sayyid SS, Zalaket MI, Baraka AS. Intravenous lidocaine as adjuvant to sevoflurane anesthesia for endotracheal intubation in children. Anesth Analg. 2003; 96(5): 1325-7[PubMed]
  • 15. Tripathi DC, Shah KS, Dubey SR, Doshi SM, Raval PV. Hemodynamic stress response during laparoscopic cholecystectomy: Effect of two different doses of intravenous clonidine premedication. J Anaesthesiol Clin Pharmacol. 2011; 27(4): 475-80[DOI][PubMed]
  • 16. Ebneshahidi A, Mohseni M. Premedication with oral clonidine decreases intraoperative bleeding and provides hemodynamic stability in cesarean section. Anesth Pain Med. 2011; 1(1): 30-3[DOI][PubMed]
  • 17. Muzi M, Goff DR, Kampine JP, Roerig DL, Ebert TJ. Clonidine reduces sympathetic activity but maintains baroreflex responses in normotensive humans. Anesthesiology. 1992; 77(5): 864-71[PubMed]
  • 18. Pouttu J, Scheinin B, Rosenberg PH, Viinamaki O, Scheinin M. Oral premedication with clonidine: effects on stress responses during general anaesthesia. Acta Anaesthesiol Scand. 1987; 31(8): 730-4[PubMed]
  • 19. Quintin L, Roudot F, Roux C, Macquin I, Basmaciogullari A, Guyene T, et al. Effect of clonidine on the circulation and vasoactive hormones after aortic surgery. Br J Anaesth. 1991; 66(1): 108-15[PubMed]
  • 20. Byrd BF, 3rd, Collins HW, Primm RK. Risk factors for severe bradycardia during oral clonidine therapy for hypertension. Arch Intern Med. 1988; 148(3): 729-33[PubMed]
  • 21. Routray SS, Raut K, Biswal D, Pradhan K, Mishra D. A Comparative Study of Fentanyl-Clonidine and Fentanyl-Lidocaine on Attenuation of Hemodynamic Stress Response to Laryngoscopy and Tracheal Intubation in Hypertensive Patients. 2 2014; 4: 27-31
  • 22. Shribman AJ, Smith G, Achola KJ. Cardiovascular and catecholamine responses to laryngoscopy with and without tracheal intubation. Br J Anaesth. 1987; 59(3): 295-9[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments