Anesthesiology and Pain Medicine

Published by: Kowsar

Efficacy of Pregabalin as Premedication for Post-Operative Analgesia in Vaginal Hysterectomy

Geetha Chamanhalli Rajappa 1 , * , Saurabh Vig 2 , Yatish Bevanaguddaiah 1 and Tejesh C Anadaswamy 1
Authors Information
1 Department of Anaesthesiology, MS Ramaiah Medical College, Bangalore, India
2 Department of Anaesthesiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
Article information
  • Anesthesiology and Pain Medicine: June 01, 2016, 6 (3); e34591
  • Published Online: May 14, 2016
  • Article Type: Research Article
  • Received: November 11, 2015
  • Revised: December 28, 2015
  • Accepted: January 26, 2016
  • DOI: 10.5812/aapm.34591

To Cite: Rajappa G C, Vig S, Bevanaguddaiah Y, Anadaswamy T C. Efficacy of Pregabalin as Premedication for Post-Operative Analgesia in Vaginal Hysterectomy, Anesth Pain Med. 2016 ; 6(3):e34591. doi: 10.5812/aapm.34591.

Copyright © 2016, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Cashman JN, Dolin SJ. Respiratory and haemodynamic effects of acute postoperative pain management: evidence from published data. Br J Anaesth. 2004; 93(2): 212-23[DOI][PubMed]
  • 2. Dolin SJ, Cashman JN. Tolerability of acute postoperative pain management: nausea, vomiting, sedation, pruritus, and urinary retention. Evidence from published data. Br J Anaesth. 2005; 95(5): 584-91[DOI][PubMed]
  • 3. Ong CK, Lirk P, Tan CH, Seymour RA. An evidence-based update on nonsteroidal anti-inflammatory drugs. Clin Med Res. 2007; 5(1): 19-34[DOI][PubMed]
  • 4. Gajraj NM. Pregabalin: its pharmacology and use in pain management. Anesth Analg. 2007; 105(6): 1805-15[DOI][PubMed]
  • 5. Imani F, Rahimzadeh P. Gabapentinoids: gabapentin and pregabalin for postoperative pain management. Anesth Pain Med. 2012; 2(2): 52-3[DOI][PubMed]
  • 6. Tiippana EM, Hamunen K, Kontinen VK, Kalso E. Do surgical patients benefit from perioperative gabapentin/pregabalin? A systematic review of efficacy and safety. Anesth Analg. 2007; 104(6): 1545-56[DOI][PubMed]
  • 7. Kohli M, Murali T, Gupta R, Khan P, Bogra J. Optimization of subarachanoid block by oral pregabalin for hysterectomy. J Anaesthesiol Clin Pharmacol. 2011; 27(1): 101-5[PubMed]
  • 8. Ghai A, Gupta M, Hooda S, Singla D, Wadhera R. A randomized controlled trial to compare pregabalin with gabapentin for postoperative pain in abdominal hysterectomy. Saudi J Anaesth. 2011; 5(3): 252-7[DOI][PubMed]
  • 9. Jokela R, Ahonen J, Tallgren M, Haanpaa M, Korttila K. Premedication with pregabalin 75 or 150 mg with ibuprofen to control pain after day-case gynaecological laparoscopic surgery. Br J Anaesth. 2008; 100(6): 834-40[DOI][PubMed]
  • 10. Julius D, Basbaum AI. Molecular mechanisms of nociception. Nature. 2001; 413(6852): 203-10[DOI][PubMed]
  • 11. Werner MU, Mjobo HN, Nielsen PR, Rudin A. Prediction of postoperative pain: a systematic review of predictive experimental pain studies. Anesthesiology. 2010; 112(6): 1494-502[DOI][PubMed]
  • 12. Carli F, Baldini G. Morgan and Mikhail's Clinical Anesthesiology. 2007; : 1087-106
  • 13. Hurley RW, Wu CL. Miller's Anesthesia. 2010; : 2757-82
  • 14. Vadivelu N, Mitra S, Narayan D. Recent advances in postoperative pain management. Yale J Biol Med. 2010; 83(1): 11-25[PubMed]
  • 15. Bandelow B, Wedekind D, Leon T. Pregabalin for the treatment of generalized anxiety disorder: a novel pharmacologic intervention. Expert Rev Neurother. 2007; 7(7): 769-81[DOI][PubMed]
  • 16. White PF, Tufanogullari B, Taylor J, Klein K. The effect of pregabalin on preoperative anxiety and sedation levels: a dose-ranging study. Anesth Analg. 2009; 108(4): 1140-5[DOI][PubMed]
  • 17. Agarwal A, Gautam S, Gupta D, Agarwal S, Singh PK, Singh U. Evaluation of a single preoperative dose of pregabalin for attenuation of postoperative pain after laparoscopic cholecystectomy. Br J Anaesth. 2008; 101(5): 700-4[DOI][PubMed]
  • 18. Alimian M, Imani F, Faiz SH, Pournajafian A, Navadegi SF, Safari S. Effect of oral pregabalin premedication on post-operative pain in laparoscopic gastric bypass surgery. Anesth Pain Med. 2012; 2(1): 12-6[DOI][PubMed]
  • 19. Paech MJ, Goy R, Chua S, Scott K, Christmas T, Doherty DA. A randomized, placebo-controlled trial of preoperative oral pregabalin for postoperative pain relief after minor gynecological surgery. Anesth Analg. 2007; 105(5): 1449-53[DOI][PubMed]
  • 20. Ittichaikulthol W, Virankabutra T, Kunopart M, Khamhom W, Putarawuthichai P, Rungphet S. Effects of pregabalin on post operative morphine consumption and pain after abdominal hysterectomy with/without salphingo-oophorectomy: a randomized, double-blind trial. J Med Assoc Thai. 2009; 92(10): 1318-23[PubMed]
  • 21. Rose MA, Kam PC. Gabapentin: pharmacology and its use in pain management Anaesthesia 2002; 57: 451-62[PubMed]
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