Anesthesiology and Pain Medicine

Published by: Kowsar

Diclofenac Suppository vs. IV Acetaminophen Combined With IV PCA for Postoperative Pain Management in Patients Undergoing Laminectomy: A Randomized, Double-Blinded Clinical Trial

Mahshid Nikooseresht 1 , Mohammad Ali Seifrabiei 2 , Maryam Davoodi 1 , Mashhood Aghajanlou 3 and Mohammad Taghi Sardari 4 , *
Authors Information
1 Department of Anesthesiology, Hamadan University of Medical Sciences, Hamadan, Iran
2 Department of Social Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3 Department of Neurosurgery, Hamadan University of Medical Sciences, Hamadan, Iran
4 Department of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Article information
  • Anesthesiology and Pain Medicine: June 01, 2016, 6 (3); e36812
  • Published Online: June 18, 2016
  • Article Type: Research Article
  • Received: February 1, 2016
  • Revised: May 7, 2016
  • Accepted: May 30, 2016
  • DOI: 10.5812/aapm.36812

To Cite: Nikooseresht M, Seifrabiei M A, Davoodi M, Aghajanlou M, Sardari M T. Diclofenac Suppository vs. IV Acetaminophen Combined With IV PCA for Postoperative Pain Management in Patients Undergoing Laminectomy: A Randomized, Double-Blinded Clinical Trial, Anesth Pain Med. 2016 ; 6(3):e36812. doi: 10.5812/aapm.36812.

Copyright © 2016, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Anastase DM, Cionac Florescu S, Munteanu AM, Ursu T, Stoica CI. Analgesic techniques in hip and knee arthroplasty: from the daily practice to evidence-based medicine. Anesthesiol Res Pract. 2014; 2014: 569319[DOI][PubMed]
  • 2. Svensson I, Sjostrom B, Haljamae H. Assessment of pain experiences after elective surgery. J Pain Symptom Manage. 2000; 20(3): 193-201[PubMed]
  • 3. Apfelbaum JL, Chen C, Mehta SS, Gan TJ. Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg. 2003; 97(2): 534-40[PubMed]
  • 4. Imani F. Postoperative pain management. Anesth Pain Med. 2011; 1(1): 6-7[DOI][PubMed]
  • 5. Alavi SM, Kish RF, Farsad F, Imani F, Sheikhvatan M. Intravenous sufentanil and morphine for post-cardiac surgery pain relief using patient-controlled analgesia (PCA) device: A randomized double-blind clinical trial. Pak J Med Sci. 2010; 26(1): 137-41
  • 6. Acute pain management: the scientific evidence. 2005;
  • 7. Best practice statement, Postoperative Pain Managemen. 2004;
  • 8. Aldwinckle RJ, Montgomery JE. Unplanned admission rates and postdischarge complications in patients over the age of 70 following day case surgery. Anaesthesia. 2004; 59(1): 57-9[PubMed]
  • 9. Tighe SQ, Bie JA, Nelson RA, Skues MA. The acute pain service: effective or expensive care? Anaesthesia. 1998; 53(4): 397-403[PubMed]
  • 10. Imani F, Entezary S, Razi M, Jafarian AA, Yousefshahi F, Etemadi H, et al. The effect of intra-articular meperidine and bupivacaine 0.5% on postoperative pain of arthroscopic knee surgery; a randomized double blind clinical trial. Anesth Pain Med. 2015; 5(1)[DOI][PubMed]
  • 11. Miaskowski C, Crews J, Ready LB, Paul SM, Ginsberg B. Anesthesia-based pain services improve the quality of postoperative pain management. Pain. 1999; 80(1-2): 23-9[PubMed]
  • 12. Coleman SA, Booker-Milburn J. Audit of postoperative pain control. Influence of a dedicated acute pain nurse. Anaesthesia. 1996; 51(12): 1093-6[PubMed]
  • 13. Mackintosh C, Bowles S. Evaluation of a nurse-led acute pain service. Can clinical nurse specialists make a difference? J Adv Nurs. 1997; 25(1): 30-7[PubMed]
  • 14. Moss E, Taverner T, Norton P, Lesser P, Cole P. A survey of postoperative pain management in fourteen hospitals in the UK. Acute Pain. 2005; 7(1): 13-20
  • 15. Imani F, Faiz HR, Sedaghat M, Hajiashrafi M. Effects of adding ketamine to fentanyl plus acetaminophen on postoperative pain by patient controlled analgesia in abdominal surgery. Anesth Pain Med. 2014; 4(1)[DOI][PubMed]
  • 16. Kehlet H, Holte K. Effect of postoperative analgesia on surgical outcome. Br J Anaesth. 2001; 87(1): 62-72[PubMed]
  • 17. Gharaei H, Imani F, Almasi F, Solimani M. The Effect of Ultrasound-guided TAPB on Pain Management after Total Abdominal Hysterectomy. Korean J Pain. 2013; 26(4): 374-8[DOI][PubMed]
  • 18. Powell AE, Davies HT, Bannister J, Macrae WA. Rhetoric and reality on acute pain services in the UK: a national postal questionnaire survey. Br J Anaesth. 2004; 92(5): 689-93[DOI][PubMed]
  • 19. Dolin SJ, Cashman JN, Bland JM. Effectiveness of acute postoperative pain management: I. Evidence from published data. Br J Anaesth. 2002; 89(3): 409-23[PubMed]
  • 20. Rahimzadeh P, Imani F, Faiz SH, Nikoubakht N, Sayarifard A. Effect of intravenous methylprednisolone on pain after intertrochanteric femoral fracture surgery. J Clin Diagn Res. 2014; 8(4)-4[DOI][PubMed]
  • 21. Macrae WA. Chronic pain after surgery. Br J Anaesth. 2001; 87(1): 88-98[PubMed]
  • 22. Perkins FM, Kehlet H. Chronic pain as an outcome of surgery. A review of predictive factors. Anesthesiology. 2000; 93(4): 1123-33[PubMed]
  • 23. Peters ML, Sommer M, de Rijke JM, Kessels F, Heineman E, Patijn J, et al. Somatic and psychologic predictors of long-term unfavorable outcome after surgical intervention. Ann Surg. 2007; 245(3): 487-94[DOI][PubMed]
  • 24. Alimian M, Imani F, Faiz SH, Pournajafian A, Navadegi SF, Safari S. Effect of oral pregabalin premedication on post-operative pain in laparoscopic gastric bypass surgery. Anesth Pain Med. 2012; 2(1): 12-6[DOI][PubMed]
  • 25. Kehlet H, Dahl JB. The value of "multimodal" or "balanced analgesia" in postoperative pain treatment. Anesth Analg. 1993; 77(5): 1048-56[PubMed]
  • 26. Turgut N, Turkmen A, Gokkaya S, Altan A, Hatiboglu MA. Dexmedetomidine-based versus fentanyl-based total intravenous anesthesia for lumbar laminectomy. Minerva Anestesiol. 2008; 74(9): 469-74[PubMed]
  • 27. Peng PW, Sandler AN. A review of the use of fentanyl analgesia in the management of acute pain in adults. Anesthesiology. 1999; 90(2): 576-99[PubMed]
  • 28. Joshi GP, McCarroll SM, O'Rourke K. Postoperative analgesia after lumbar laminectomy: epidural fentanyl infusion versus patient-controlled intravenous morphine. Anesth Analg. 1995; 80(3): 511-4[PubMed]
  • 29. Maund E, McDaid C, Rice S, Wright K, Jenkins B, Woolacott N. Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs for the reduction in morphine-related side-effects after major surgery: a systematic review. Br J Anaesth. 2011; 106(3): 292-7[DOI][PubMed]
  • 30. Dhawan N, Das S, Kiran U, Chauhan S, Bisoi AK, Makhija N. Effect of rectal diclofenac in reducing postoperative pain and rescue analgesia requirement after cardiac surgery. Pain Pract. 2009; 9(5): 385-93[DOI][PubMed]
  • 31. Kuzucuoglu T, Ozok AO, Yakupoglu S, Alatli I, Ital I. Comparison of the effects of diclofenac sodium and paracetamol on morphine consumption and quality of analgesia in patient controlled anesthesia method. J Marmara Univ Inst Health Sci. 2011; 1(2): 117
  • 32. Gulcin Ural S, Yener O, Sahin H, Simsek T, Aydinli B, Ozgok A. The comparison of analgesic effects of various administration methods of diclofenac sodium, transdermal, oral and intramuscular, in early postoperative period in laparoscopic cholecystectomy operations. Pak J Med Sci. 2014; 30(1): 96-100[DOI][PubMed]
  • 33. Darvish H, Memar Ardestani B, Mohammadkhani Shali S, Tajik A. Analgesic Efficacy of Diclofenac and Paracetamol vs. Meperidine in Cesarean Section. Anesth Pain Med. 2014; 4(1)[DOI][PubMed]
  • 34. Sharma S, Balireddy RK, Vorenkamp KE, Durieux ME. Beyond opioid patient-controlled analgesia: a systematic review of analgesia after major spine surgery. Reg Anesth Pain Med. 2012; 37(1): 79-98[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments