Anesthesiology and Pain Medicine

Published by: Kowsar

Comparing the Effects of Isoflurane-Sufentanil Anesthesia and Propofol-Sufentanil Anesthesia on Serum Cortisol Levels in Open Heart Surgery with Cardiopulmonary Bypass

Abbas Sedighinejad 1 , Vali Imantalab 1 , * , Ali Mirmansouri 1 , Bahram Naderi Nabi 2 , Masoud Tarbiat 1 , Ali Mohammad Sadeghi 3 , Nassir Nassiri Sheikhani 3 , Mohammad Haghighi 4 and Zahra Sayahe Varag 5
Authors Information
1 Associate Professor of Anesthesiology, Fellowship of Anesthesia in Cardiac Surgery, Anesthesiology Research Center, Guilan University of Medical Sciences (GUMS), Rasht, Iran
2 MD, Associate Professor of Anesthesiology, Fellowship of Anesthesia and Pain (FIPP), Anesthesiology Department, Anesthesiology Research Center, Guilan University of Medical Sciences, Rasht, Iran
3 Department of Cardiology, Assistant Professor of Cardiac Surgery, Guilan University of Medical Sciences, Rasht, Iran
4 Associate Professor of Anesthesiology, Anesthesiology Research Center, Guilan University of Medical Sciences (GUMS), Rasht, Iran
5 Department of Anesthesiology, Anesthesiology Research Center, Guilan University of Medical Sciences, Rasht, Iran
Article information
  • Anesthesiology and Pain Medicine: December 01, 2016, 6 (6); e42066
  • Published Online: November 21, 2016
  • Article Type: Research Article
  • Received: September 4, 2016
  • Revised: October 13, 2016
  • Accepted: November 5, 2016
  • DOI: 10.5812/aapm.42066

To Cite: Sedighinejad A, Imantalab V, Mirmansouri A, Naderi Nabi B, Tarbiat M, et al. Comparing the Effects of Isoflurane-Sufentanil Anesthesia and Propofol-Sufentanil Anesthesia on Serum Cortisol Levels in Open Heart Surgery with Cardiopulmonary Bypass, Anesth Pain Med. 2016 ; 6(6):e42066. doi: 10.5812/aapm.42066.

Copyright © 2016, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Aggo AT, Fyneface-Ogan S, Mato CN. The differential impact of two anesthetic techniques on cortisol levels in Nigerian surgical patients. Niger J Clin Pract. 2012; 15(1): 68-74[DOI][PubMed]
  • 2. Taylor KM, Jones JV, Walker MS, Rao S, Bain WH. The cortisol response during heart-lung bypass. Circulation. 1976; 54(1): 20-5[PubMed]
  • 3. Chen X, Thee C, Gruenewald M, Ilies C, Hocker J, Hanss R, et al. Correlation of surgical pleth index with stress hormones during propofol-remifentanil anaesthesia. ScientificWorldJournal. 2012; 2012: 879158[DOI][PubMed]
  • 4. Mujagic Z, Cicko E, Vegar-Brozovic V, Praso M. Serum levels of cortisol and prolactin in patients treated under total intravenous anesthesia with propofol-fentanyl and under balanced anesthesia with isoflurane-fentanyl. Open Med. 2008; 3(4)[DOI]
  • 5. Cok OY, Ozkose Z, Pasaoglu H, Yardim S. Glucose response during craniotomy: propofol-remifentanil versus isoflurane-remifentanil. Minerva Anestesiol. 2011; 77(12): 1141-8[PubMed]
  • 6. Marrocco-Trischitta MM, Tiezzi A, Svampa MG, Bandiera G, Camilli S, Stillo F, et al. Perioperative stress response to carotid endarterectomy: the impact of anesthetic modality. J Vasc Surg. 2004; 39(6): 1295-304[DOI][PubMed]
  • 7. Norman JG, Fink GW. The effects of epidural anesthesia on the neuroendocrine response to major surgical stress: a randomized prospective trial. Am Surg. 1997; 63(1): 75-80[PubMed]
  • 8. Anaesthesia and stress response to surgery. Proceedings of the latvian academy of sciences. Section b. Natural, exact, and applied sciences. : 141-7
  • 9. Burton D, Nicholson G, Hall G. Endocrine and metabolic response to surgery. Continuing Education In Anaesthesia, Critical Care & Pain. 2004; 4(5): 144-7[DOI]
  • 10. Scholl R, Bekker A, Babu R. Neuroendocrine and immune responses to surgery. Internet J Anesthesiol. 2012; 30(3)
  • 11. Ji FH, Wang YL, Yang JP. Effects of propofol anesthesia and sevoflurane anesthesia on the differentiation of human T-helper cells during surgery. Chin Med J (Engl). 2011; 124(4): 525-9[PubMed]
  • 12. Shaikh S, Verma H, Yadav N, Jauhari M, Bullangowda J. Applications of steroid in clinical practice: a review. ISRN Anesthesiol. 2012; 2012
  • 13. Sedighinejad A, Imantalab V, Mirmansouri A, Mohammadzadeh Jouryabi A, Kanani G, Nassiri Sheikhani N, et al. Effects of Low-dose Selenium on the Inflammatory Response in Coronary Artery Bypass Graft Surgery: A Clinical Trial. Iran Red Crescent Med J. 2016; 18(8)[DOI][PubMed]
  • 14. Imantalab V, Mirmansouri A, Sedighinejad A, Naderi Nabi B, Farzi F, Atamanesh H, et al. Comparing the effects of morphine sulfate and diclofenac suppositories on postoperative pain in coronary artery bypass graft patients. Anesth Pain Med. 2014; 4(4)[DOI][PubMed]
  • 15. Farzi F, Naderi Nabi B, Mirmansouri A, Fakoor F, Atrkar Roshan Z, Biazar G, et al. Postoperative pain after abdominal hysterectomy: A randomized, double-blind, controlled trial comparing the effects of tramadol and gabapentin as premedication. Anesth Pain Med. 2016; 6(1)[DOI]
  • 16. Nabi BN, Sedighinejad A, Haghighi M, Biazar G, Hashemi M, Haddadi S, et al. Comparison of transcutaneous electrical nerve stimulation and pulsed radiofrequency sympathectomy for treating painful diabetic neuropathy. Anesth Pain Med. 2015; 5(5)[DOI][PubMed]
  • 17. Sedighinejad A, Haghighi M, Naderi Nabi B, Rahimzadeh P, Mirbolook A, Mardani-Kivi M, et al. Magnesium sulfate and sufentanil for patient-controlled analgesia in orthopedic surgery. Anesth Pain Med. 2014; 4(1)[DOI][PubMed]
  • 18. Marzban S, Haddadi S, Mahmoudi Nia H, Heidarzadeh A, Nemati S, Naderi Nabi B. Comparison of surgical conditions during propofol or isoflurane anesthesia for endoscopic sinus surgery. Anesth Pain Med. 2013; 3(2): 234-8[DOI][PubMed]
  • 19. Imantalab V, Seddighi Nejad A, Mir Mansouri A, Sadeghi Meibodi A, Haghighi M, Dadkhah H, et al. A comparative study of cardioprotective effect of three anesthetic agents by measuring serum level of troponin-T after coronary artery bypass grafting. Int Cardiovasc Res J. 2012; 6(3): 70-4[PubMed]
  • 20. Adams HA, Schmitz CS, Baltes-Gotz B. [Endocrine stress reaction, hemodynamics and recovery in total intravenous and inhalation anesthesia. Propofol versus isoflurane]. Anaesthesist. 1994; 43(11): 730-7[PubMed]
  • 21. Hoda MR, El-Achkar H, Schmitz E, Scheffold T, Vetter HO, De Simone R. Systemic stress hormone response in patients undergoing open heart surgery with or without cardiopulmonary bypass. Ann Thorac Surg. 2006; 82(6): 2179-86[DOI][PubMed]
  • 22. Sedighinejad A, Naderi Nabi B, Haghighi M, Biazar G, Imantalab V, Rimaz S, et al. Comparison of the Effects of Low-Dose Midazolam, Magnesium Sulfate, Remifentanil and Low-Dose Etomidate on Prevention of Etomidate-Induced Myoclonus in Orthopedic Surgeries. Anesth Pain Med. 2016; 6(2)[DOI][PubMed]
  • 23. Sedighinejad A, Naderi Nabi B, Haghighi M, Imantalab V, Hadadi S, Erfani Sayar R, et al. Propofol is Effective to Depress Fentanyl-Induced Cough during Induction of Anesthesia. Anesth Pain Med. 2013; 2(4): 170-3[DOI][PubMed]
  • 24. Ram E, Vishne TH, Weinstein T, Beilin B, Dreznik Z. General anesthesia for surgery influences melatonin and cortisol levels. World J Surg. 2005; 29(7): 826-9[DOI][PubMed]
  • 25. Kelbel I, Weiss M. Anaesthetics and immune function. Curr Opin Anaesthesiol. 2001; 14(6): 685-91[PubMed]
  • 26. Nussmeier NNA, Sarwar M. Anesthesia for cardiac surgical procedures. Miller's anesthesia. 2015; : 2047-9
  • 27. VuykJ S, Reekers M. Intravenous anesthetics. Miller's anesthesia. 2015; : 829
  • 28. Schricker T, Carli F, Schreiber M, Wachter U, Geisser W, Lattermann R, et al. Propofol/sufentanil anesthesia suppresses the metabolic and endocrine response during, not after, lower abdominal surgery. Anesth. Analg. 2000; 90(2): 450-5
  • 29. Ihn CH, Joo JD, Choi JW, Kim DW, Jeon YS, Kim YS, et al. Comparison of stress hormone response, interleukin-6 and anaesthetic characteristics of two anaesthetic techniques: volatile induction and maintenance of anaesthesia using sevoflurane versus total intravenous anaesthesia using propofol and remifentanil. J Int Med Res. 2009; 37(6): 1760-71[PubMed]
  • 30. Van Hemelrijck J, Weekers F, Van Aken H, Bouillon R, Heyns W. Propofol anesthesia does not inhibit stimulation of cortisol synthesis. Anesth. Analg. 1995; 80(3): 573-6[DOI]
  • 31. Modifying the neuroendocrine stress response. Seminars in anesthesia, perioperative medicine and pain. : 16-25
  • 32. Velissaris T, Tang ATM, Murray M, Mehta RL, Wood PJ, Hett DA, et al. A prospective randomized study to evaluate stress response during beating-heart and conventional coronary revascularization. Ann Thorac Surg. 2004; 78(2): 506-12[DOI]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments