Anesthesiology and Pain Medicine

Published by: Kowsar

The Role of Inhalational Anesthetic Drugs in Patients With Hepatic Dysfunction: A Review Article

Hassan Soleimanpour 1 , Saeid Safari 2 , Farzad Rahmani 3 , Hoorolnesa Ameli 4 and Seyed Moayed Alavian 5 , *
Authors Information
1 Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Department of Anesthesiology, Iran University of Medical Sciences, Tehran, Iran
3 Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4 Students’ Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
5 Hepatitis B Molecular Laboratory, Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Article information
  • Anesthesiology and Pain Medicine: February 01, 2015, 5 (1); e23409
  • Published Online: January 7, 2015
  • Article Type: Review Article
  • Received: September 9, 2014
  • Revised: September 26, 2014
  • Accepted: December 14, 2014
  • DOI: 10.5812/aapm.23409

To Cite: Soleimanpour H, Safari S, Rahmani F, Ameli H, Alavian S M. The Role of Inhalational Anesthetic Drugs in Patients With Hepatic Dysfunction: A Review Article, Anesth Pain Med. 2015 ; 5(1):e23409. doi: 10.5812/aapm.23409.

Copyright © 2015, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Results
4. Conclusions
  • 1. Kamath PS, Kim WR, Advanced Liver Disease Study G. The model for end-stage liver disease (MELD). Hepatology. 2007; 45(3): 797-805[DOI][PubMed]
  • 2. Manti S, Marseglia L, D'Angelo G, Filippelli M, Cuppari C, Gitto E, et al. Portal hypertension as immune mediate disease. Hepat Mon. 2014; 14(6)[DOI][PubMed]
  • 3. Murray JF, Dawson AM, Sherlock S. Circulatory changes in chronic liver disease. Am J Med. 1958; 24(3): 358-67[PubMed]
  • 4. Mahboobi N, Esmaili S, Safari S, Habibollahi P, Dabbagh A, Alavian SM. Halothane: How should it be treated in a developing country? EMHJ. 2011;
  • 5. Golzari SE, Soleimanpour H, Rahmani F, Zamani Mehr N, Safari S, Heshmat Y, et al. Therapeutic approaches for renal colic in the emergency department: a review article. Anesth Pain Med. 2014; 4(1)[DOI][PubMed]
  • 6. Shams Vahdati S, Morteza Baghi HR, Ghobadi J, Rajaei Ghafouri R, Habibollahi P. Comparison of paracetamol (apotel(R)) and morphine in reducing post pure head trauma headache. Anesth Pain Med. 2014; 4(3)[DOI][PubMed]
  • 7. Longo D, Fauci A, Kasper D, Hauser S, Jameson J, Loscalzo J. Harrison's Principles of Internal Medicine, 18th Edition. 2011;
  • 8. Parker BM, Bhatia S, Younossi Z, Henderson JM, Tetzlaff JE. Autonomic dysfunction in end-stage liver disease manifested as defecation syncope: impact of orthotopic liver transplantation. Liver Transpl Surg. 1999; 5(6): 497-501[PubMed]
  • 9. De Wolf AM. 6/2/06 Perioperative assessment of the cardiovascular system in ESLD and transplantation. Int Anesthesiol Clin. 2006; 44(4): 59-78[DOI][PubMed]
  • 10. Durak I, Guven T, Birey M, Ozturk HS, Kurtipek O, Yel M, et al. Halothane hepatotoxicity and hepatic free radical metabolism in guinea pigs; the effects of vitamin E. Can J Anaesth. 1996; 43(7): 741-8[DOI][PubMed]
  • 11. Tripodi A, Mannucci PM. The coagulopathy of chronic liver disease. N Engl J Med. 2011; 365(2): 147-56[DOI][PubMed]
  • 12. Vaja R, McNicol L, Sisley I. Anaesthesia for patients with liver disease. Continuing Education in Anaesthesia, Critical Care & Pain. 2010; 10(1): 15-9
  • 13. Dabbagh A, Rajaei S. The role of anesthetic drugs in liver apoptosis. Hepat Mon. 2013; 13(8)[DOI][PubMed]
  • 14. Soleimanpour H, Gholipouri C, Panahi JR, Afhami MR, Ghafouri RR, Golzari SE, et al. Role of anesthesiology curriculum in improving bag-mask ventilation and intubation success rates of emergency medicine residents: a prospective descriptive study. BMC Emerg Med. 2011; 11: 8[DOI][PubMed]
  • 15. Soleimanpour H, Panahi JR, Mahmoodpoor A, Rajaei Ghafouri R. Digital intubation training in residency program, as an alternative method in airway management. Pakistan J Med Sci. 2011; 27(2)
  • 16. Soleimanpour H, Gholipouri C, Golzari SEJ, Rahmani F, Sabahi M. Capnography in the emergency department. Emergency Med. 2012; 2
  • 17. Suckling CW. Some chemical and physical factors in the development of fluothane. Br J Anaesth. 1957; 29(10): 466-72[PubMed]
  • 18. Miller RD. Miller's Anesthesia: .... 1. 2010;
  • 19. Nishiyama T, Yokoyama T, Hanaoka K. Liver function after sevoflurane or isoflurane anaesthesia in neurosurgical patients. Can J Anaesth. 1998; 45(8): 753-6[DOI][PubMed]
  • 20. Malhotra P, Mychaskiw G, Rai A. Desflurane versus opioid anesthesia for cardiac shunt procedures in infants with cyantoic congential heart disease. Anesth Pain Med. 2013; 3(1): 191-7[DOI][PubMed]
  • 21. Anderson JS, Rose NR, Martin JL, Eger EI, Njoku DB. Desflurane hepatitis associated with hapten and autoantigen-specific IgG4 antibodies. Anesth Analg. 2007; 104(6): 1452-3[DOI][PubMed]
  • 22. Njoku DB. Drug-induced hepatotoxicity: metabolic, genetic and immunological basis. Int J Mol Sci. 2014; 15(4): 6990-7003[DOI][PubMed]
  • 23. Lee HT, Ota-Setlik A, Fu Y, Nasr SH, Emala CW. Differential protective effects of volatile anesthetics against renal ischemia-reperfusion injury in vivo. Anesthesiology. 2004; 101(6): 1313-24[PubMed]
  • 24. Zhou SP, Jiang P, Liu L, Liu H. Protective effect of sevoflurane on hepatic ischaemia/reperfusion injury in the rat: A dose-response study. Eur J Anaesthesiol. 2013; [DOI][PubMed]
  • 25. Kusuma HR, Venkataramana NK, Rao SA, Naik AL, Gangadhara D, Venkatesh KH. Fulminant hepatic failure after repeated exposure to isoflurane. Indian J Anaesth. 2011; 55(3): 290-2[DOI][PubMed]
  • 26. Rahimzadeh P, Safari S, Faiz SH, Alavian SM. Anesthesia for patients with liver disease. Hepat Mon. 2014; 14(7)[DOI][PubMed]
  • 27. Hajijafari M, Ziloochi MH, Fazel MR. Inhalation anesthesia in a patient with xeroderma pigmentosum: a case report. Anesth Pain Med. 2014; 4(3)[DOI][PubMed]
  • 28. Mohseni M, Safari S, Alavian SM. Volatile anesthetics in ischemic liver injury: enemy or friend? Hepat Mon. 2014; 14(6)[DOI][PubMed]
  • 29. Hoetzel A, Ryan H, Schmidt R. Anesthetic considerations for the patient with liver disease. Curr Opin Anaesthesiol. 2012; 25(3): 340-7[DOI][PubMed]
  • 30. Wiklund RA. Preoperative preparation of patients with advanced liver disease. Crit Care Med. 2004; 32(4 Suppl)-15[PubMed]
  • 31. Eger EI, 2nd., Koblin DD, Bowland T, Ionescu P, Laster MJ, Fang Z, et al. Nephrotoxicity of sevoflurane versus desflurane anesthesia in volunteers. Anesth Analg. 1997; 84(1): 160-8[PubMed]
  • 32. Safari S, Motavaf M, Seyed Siamdoust SA, Alavian SM. Hepatotoxicity of Halogenated Inhalational Anesthetics. Iran Red Crescent Med J. 2014; 16(9)
  • 33. Dabbagh A, Rajaei S, Golzari SE. History of anesthesia and pain in old Iranian texts. Anesth Pain Med. 2014; 4(3)[DOI][PubMed]
  • 34. Albeldawi M, Aggarwal A, Madhwal S, Cywinski J, Lopez R, Eghtesad B, et al. Cumulative risk of cardiovascular events after orthotopic liver transplantation. Liver Transpl. 2012; 18(3): 370-5[DOI][PubMed]
  • 35. Kashani A, Landaverde C, Medici V, Rossaro L. Fluid retention in cirrhosis: pathophysiology and management. QJM. 2008; 101(2): 71-85[DOI][PubMed]
  • 36. Aydin OA, Yemisen M, Karaosmanoglu HK, Sargin F, Gunduz A, Ceylan B, et al. Low Prevalence of Hepatitis C Virus Infection Among HIV-Positive Patients: Data From a Large-Scale Cohort Study in Istanbul, Turkey. Hepat Mon. 2014; 14(8)[DOI][PubMed]
  • 37. Hu Z, Yang J, Xiong G, Shi H, Yuan Y, Fan L, et al. HLA-DPB1 Variant Effect on Hepatitis B Virus Clearance and Liver Cirrhosis Development Among Southwest Chinese Population. Hepat Mon. 2014; 14(8)[DOI][PubMed]
  • 38. Keyvani H, Sohrabi M, Zamani F, Poustchi H, Ashrafi H, Saeedian F, et al. A population based study on hepatitis B virus in northern iran, amol. Hepat Mon. 2014; 14(8)[DOI][PubMed]
  • 39. Fleifel WAN. Effects of halothane anesthesia on patients with abnormal liver function tests. J Basrah Res ((Sciences)). 2011; 4: 84-92
  • 40. Ihtiyar E, Algin C, Haciolu A, Isiksoy S. Fatal isoflurane hepatotoxicity without re-exposure. Indian J Gastroenterol. 2006; 25(1): 41-2[PubMed]
  • 41. Fox E, Landrum-McNiff K, Zhong Z, Dawson NV, Wu AW, Lynn J. Evaluation of prognostic criteria for determining hospice eligibility in patients with advanced lung, heart, or liver disease. SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. JAMA. 1999; 282(17): 1638-45[PubMed]
  • 42. Huh IY, Park ES, Kim KI, Lee AR, Hwang GS. Alteration of the QT variability index in end-stage liver disease. Korean J Anesthesiol. 2014; 66(3): 199-203[DOI][PubMed]
  • 43. Katzung B, Masters S, Trevor A. Basic and Clinical Pharmacology 12/E. 2012;
  • 44. Katz RL, Bigger Jr JT. Cardiac arrhythmias during anesthesia and operation. Anesthesiology. 1970; 33(2): 193-213
  • 45. Ghayumi SM, Khalafi-Nezhad A, Jowkar Z. Pulse oximeter oxygen saturation in prediction of arterial oxygen saturation in liver transplant candidates. Hepat Mon. 2014; 14(4)[DOI][PubMed]
  • 46. Dabbagh A, Rajaei S. Halothane: Is there still any place for using the gas as an anesthetic? Hepat Mon. 2011; 11(7): 511-2[PubMed]
  • 47. Rodriguez-Roisin R, Krowka MJ. Hepatopulmonary syndrome--a liver-induced lung vascular disorder. N Engl J Med. 2008; 358(22): 2378-87[DOI][PubMed]
  • 48. Soleimanpour H, Shams Vahdati S, Mahmoodpoor A, Rahimi Panahi J, Afhami MR, Pouraghaei M, et al. Modified cricothyroidotomy in skill laboratory. J Cardiovasc Thorac Res. 2012; 4(3): 73-6[DOI][PubMed]
  • 49. Marzban S, Haddadi S, Mahmoudi Nia H, Heidarzadeh A, Nemati S, Naderi Nabi B. Comparison of surgical conditions during propofol or isoflurane anesthesia for endoscopic sinus surgery. Anesth Pain Med. 2013; 3(2): 234-8[DOI][PubMed]
  • 50. Mikatti NE, Healy TE. Hepatic injury associated with halogenated anaesthetics: cross-sensitization and its clinical implications. Eur J Anaesthesiol. 1997; 14(1): 7-14[PubMed]
  • 51. Anesthesia for patients with liver disease. Conferencias Magistrales. : 45-7
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