Anesthesiology and Pain Medicine

Published by: Kowsar

Oral Dexmedetomidine Versus Midazolam as Anesthetic Premedication in Children Undergoing Congenital Heart Surgery

Seyedeh Zahra Faritus 1 , Mehrdad Khazaee-Koohpar 1 , Mohsen Ziyaeifard 1 , * and Mohammad Javad Mehrabanian 1
Authors Information
1 Rajaie Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran
Article information
  • Anesthesiology and Pain Medicine: June 01, 2015, 5 (3); e25032
  • Published Online: June 22, 2015
  • Article Type: Research Article
  • Received: October 31, 2014
  • Revised: December 7, 2014
  • Accepted: December 24, 2014
  • DOI: 10.5812/aapm.5(3)2015.25032

To Cite: Faritus S Z, Khazaee-Koohpar M, Ziyaeifard M, Mehrabanian M J. Oral Dexmedetomidine Versus Midazolam as Anesthetic Premedication in Children Undergoing Congenital Heart Surgery, Anesth Pain Med. 2015 ; 5(3):e25032. doi: 10.5812/aapm.5(3)2015.25032.

Copyright © 2015, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Mensah GA, Forouzanfar MH, Naghavi M, Lozano R, Ezzati M, Moran A, et al. Comparable estimates of mortality and trends for cardiovascular diseases including congenital heart disease in 21 world regions in 1990 and 2010: The global burden of diseases, injuries and risk factors study. Am J Cardiol. 2013; 61(10)
  • 2. van der Linde D, Konings EE, Slager MA, Witsenburg M, Helbing WA, Takkenberg JJ, et al. Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis. J Am Coll Cardiol. 2011; 58(21): 2241-7[DOI][PubMed]
  • 3. Rosenbaum A, Kain ZN, Larsson P, Lonnqvist PA, Wolf AR. The place of premedication in pediatric practice. Paediatr Anaesth. 2009; 19(9): 817-28[PubMed]
  • 4. Savla JR, Ghai B, Bansal D, Wig J. Effect of intranasal dexmedetomidine or oral midazolam premedication on sevoflurane EC50 for successful laryngeal mask airway placement in children: a randomized, double-blind, placebo-controlled trial. Paediatr Anaesth. 2014; 24(4): 433-9[DOI][PubMed]
  • 5. Talon MD, Woodson LC, Sherwood ER, Aarsland A, McRae L, Benham T. Intranasal dexmedetomidine premedication is comparable with midazolam in burn children undergoing reconstructive surgery. J Burn Care Res. 2009; 30(4): 599-605[DOI][PubMed]
  • 6. Ghali AM, Mahfouz AK, Al-Bahrani M. Preanesthetic medication in children: A comparison of intranasal dexmedetomidine versus oral midazolam. Saudi J Anaesth. 2011; 5(4): 387-91[PubMed]
  • 7. Sheta SA, Al-Sarheed MA, Abdelhalim AA. Intranasal dexmedetomidine vs midazolam for premedication in children undergoing complete dental rehabilitation: a double-blinded randomized controlled trial. Paediatr Anaesth. 2014; 24(2): 181-9[DOI][PubMed]
  • 8. Yuen VM, Hui TW, Irwin MG, Yuen MK. A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: a double-blinded randomized controlled trial. Anesth Analg. 2008; 106(6): 1715-21[DOI][PubMed]
  • 9. Sun Y, Lu Y, Huang Y, Jiang H. Is dexmedetomidine superior to midazolam as a premedication in children? A meta-analysis of randomized controlled trials. Paediatr Anaesth. 2014; 24(8): 863-74[DOI][PubMed]
  • 10. Ramsay MA, Savege TM, Simpson BR, Goodwin R. Controlled sedation with alphaxalone-alphadolone. Br Med J. 1974; 2(5920): 656-9[PubMed]
  • 11. Hamid M, Khan MA, Khatri A, Akhtar I. Effectiveness of premedication at the time of separation from parent and mask induction in paediatric patients coming for congenital heart disease surgery. J Coll Physicians Surg Pak. 2012; 22(5): 280-4[PubMed]
  • 12. Khatavkar SS, Bakhshi RG. Comparison of nasal Midazolam with Ketamine versus nasal Midazolam as a premedication in children. Saudi J Anaesth. 2014; 8(1): 17-21[PubMed]
  • 13. Mitra S, Kazal S, Anand LK. Intranasal clonidine vs. midazolam as premedication in children: a randomized controlled trial. Indian Pediatr. 2014; 51(2): 113-8[PubMed]
  • 14. Verma RK, Paswan A, De A, Gupta S. Premedication with midazolam nasal spray: an alternative to oral midazolam in children. Anesth Pain Med. 2012; 1(4): 248-51[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments