Anesthesiology and Pain Medicine

Published by: Kowsar

Intravenous Midazolam as More Effective Than Propofol for Preventing Pruritus After Intrathecal Sufentanil in Surgical Patients: A Randomized Blinded Trial

Jalil Makarem 1 , Seyed Mohammad Mireskandari 1 , * , Afshin Jafarzadeh 1 , Laya Rahbar Nikoukar 2 and Sara Aghaii 2
Authors Information
1 Department of Anesthesiology & Critical Care, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
2 Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
Article information
  • Anesthesiology and Pain Medicine: June 2017, 7 (3); e37535
  • Published Online: August 27, 2016
  • Article Type: Research Article
  • Received: March 5, 2016
  • Revised: June 26, 2016
  • Accepted: August 17, 2016
  • DOI: 10.5812/aapm.37535

To Cite: Makarem J, Mireskandari S M, Jafarzadeh A, Rahbar Nikoukar L, Aghaii S. Intravenous Midazolam as More Effective Than Propofol for Preventing Pruritus After Intrathecal Sufentanil in Surgical Patients: A Randomized Blinded Trial, Anesth Pain Med. 2017 ; 7(3):e37535. doi: 10.5812/aapm.37535.

Abstract
Copyright © 2016, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Acknowledgements
Footnote
References
  • 1. Gwirtz KH, Young JV, Byers RS, Alley C, Levin K, Walker SG, et al. The safety and efficacy of intrathecal opioid analgesia for acute postoperative pain: seven years' experience with 5969 surgical patients at Indiana University Hospital. Anesth Analg. 1999; 88(3): 599-604[PubMed]
  • 2. Unlugenc H, Gunduz M, Guzel B, Isik G. A comparative study on the effects of intrathecal morphine added to levobupivacaine for spinal anesthesia. J Opioid Manag. 2012; 8(2): 105-13[PubMed]
  • 3. Yeh HM, Chen LK, Lin CJ, Chan WH, Chen YP, Lin CS, et al. Prophylactic intravenous ondansetron reduces the incidence of intrathecal morphine-induced pruritus in patients undergoing cesarean delivery. Anesth Analg. 2000; 91(1): 172-5[PubMed]
  • 4. Krajnik M, Zylicz Z. Understanding pruritus in systemic disease. J Pain Symptom Manage. 2001; 21(2): 151-68[PubMed]
  • 5. Kumar K, Singh SI. Neuraxial opioid-induced pruritus: An update. J Anaesthesiol Clin Pharmacol. 2013; 29(3): 303-7[DOI][PubMed]
  • 6. Szarvas S, Harmon D, Murphy D. Neuraxial opioid-induced pruritus: a review. J Clin Anesth. 2003; 15(3): 234-9[PubMed]
  • 7. Kyriakides K, Hussain SK, Hobbs GJ. Management of opioid-induced pruritus: a role for 5-HT3 antagonists? Br J Anaesth. 1999; 82(3): 439-41[PubMed]
  • 8. Horta ML, Morejon LC, da Cruz AW, Dos Santos GR, Welling LC, Terhorst L, et al. Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine-induced pruritus. Br J Anaesth. 2006; 96(6): 796-800[DOI][PubMed]
  • 9. Ganesh A, Maxwell LG. Pathophysiology and management of opioid-induced pruritus. Drugs. 2007; 67(16): 2323-33[PubMed]
  • 10. Graham AC, McClure JH. Quantitative assessment of motor block in labouring women receiving epidural analgesia. Anaesthesia. 2001; 56(5): 470-6[PubMed]
  • 11. Ramsay MA, Savege TM, Simpson BR, Goodwin R. Controlled sedation with alphaxalone-alphadolone. Br Med J. 1974; 2(5920): 656-9[PubMed]
  • 12. Phan NQ, Blome C, Fritz F, Gerss J, Reich A, Ebata T, et al. Assessment of pruritus intensity: prospective study on validity and reliability of the visual analogue scale, numerical rating scale and verbal rating scale in 471 patients with chronic pruritus. Acta Derm Venereol. 2012; 92(5): 502-7[DOI][PubMed]
  • 13. Cohen LB, Cattau E, Goetsch A, Shah A, Weber JR, Rex DK, et al. A randomized, double-blind, phase 3 study of fospropofol disodium for sedation during colonoscopy. J Clin Gastroenterol. 2010; 44(5): 345-53[DOI][PubMed]
  • 14. Prieto LN. The use of midazolam to treat itching in a terminally ill patient with biliary obstruction. J Pain Symptom Manage. 2004; 28(6): 531-2[DOI][PubMed]
  • 15. Thomsen JS, Benfeldt E, Serup J. Suppression of spontaneous scratching in hairless rats by sedatives but not by antipruritics. Skin Pharmacol Appl Skin Physiol. 2002; 15(4): 218-24[PubMed]
  • 16. Kim SN, Son SC, Lee SM, Kim CS, Yoo DG, Lee SK, et al. Midazolam inhibits proinflammatory mediators in the lipopolysaccharide-activated macrophage. Anesthesiology. 2006; 105(1): 105-10[PubMed]
  • 17. Borgeat A, Wilder-Smith OH, Saiah M, Rifat K. Subhypnotic doses of propofol relieve pruritus induced by epidural and intrathecal morphine. Anesthesiology. 1992; 76(4): 510-2[PubMed]
  • 18. Beilin Y, Bernstein HH, Zucker-Pinchoff B, Zahn J, Zenzen WJ. Subhypnotic doses of propofol do not relieve pruritus induced by intrathecal morphine after cesarean section. Anesth Analg. 1998; 86(2): 310-3[PubMed]
  • 19. Warwick JP, Kearns CF, Scott WE. The effect of subhypnotic doses of propofol on the incidence of pruritus after intrathecal morphine for caesarean section. Anaesthesia. 1997; 52(3): 270-5[PubMed]
  • 20. Charuluxananan S, Kyokong O, Somboonviboon W, Lertmaharit S, Ngamprasertwong P, Nimcharoendee K. Nalbuphine versus propofol for treatment of intrathecal morphine-induced pruritus after cesarean delivery. Anesth Analg. 2001; 93(1): 162-5[PubMed]
  • 21. Saiah M, Borgeat A, Wilder-Smith OH, Rifat K, Suter PM. Epidural-morphine-induced pruritus: propofol versus naloxone. Anesth Analg. 1994; 78(6): 1110-3[PubMed]
  • 22. Inada T, Kubo K, Kambara T, Shingu K. Propofol inhibits cyclo-oxygenase activity in human monocytic THP-1 cells. Can J Anaesth. 2009; 56(3): 222-9[DOI][PubMed]
  • 23. Peduto VA, Concas A, Santoro G, Biggio G, Gessa GL. Biochemical and electrophysiologic evidence that propofol enhances GABAergic transmission in the rat brain. Anesthesiology. 1991; 75(6): 1000-9[PubMed]
  • 24. Schüttler J, Schwilden H. Modern anesthetics. 2008;
  • 25. Xia WF, Liu Y, Zhou QS, Tang QZ, Zou HD. Comparison of the effects of propofol and midazolam on inflammation and oxidase stress in children with congenital heart disease undergoing cardiac surgery. Yonsei Med J. 2011; 52(2): 326-32[DOI][PubMed]
  • 26. Short TG, Chui PT. Propofol and midazolam act synergistically in combination. Br J Anaesth. 1991; 67(5): 539-45[PubMed]
  • 27. McClune S, McKay AC, Wright PM, Patterson CC, Clarke RS. Synergistic interaction between midazolam and propofol. Br J Anaesth. 1992; 69(3): 240-5[PubMed]
  • 28. Rasooli S, Moslemi F, Khaki A. Effect of Sub hypnotic Doses of Propofol and Midazolam for Nausea and Vomiting During Spinal Anesthesia for Cesarean Section. Anesth Pain Med. 2014; 4(4)[DOI][PubMed]
  • 29. Swegle JM, Logemann C. Management of common opioid-induced adverse effects. Am Fam Physician. 2006; 74(8): 1347-54[PubMed]
  • 30. Imani F, Zafarghandi-Motlagh M. Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopy. J Minim Invasive Surg Sci. 2013; 2(4)
  • 31. Hatamabadi HR, Arhami Dolatabadi A, Derakhshanfar H, Younesian S, Ghaffari Shad E. Propofol Versus Midazolam for Procedural Sedation of Anterior Shoulder Dislocation in Emergency Department: A Randomized Clinical Trial. Trauma Mon. 2015; 20(2)[DOI][PubMed]
  • 32. Gurbulak B, Uzman S, Kabul Gurbulak E, Gul YG, Toptas M, Baltali S, et al. Cardiopulmonary safety of propofol versus midazolam/meperidine sedation for colonoscopy: a prospective, randomized, double-blinded study. Iran Red Crescent Med J. 2014; 16(11)[DOI][PubMed]
  • 33. Carvalho B. Respiratory depression after neuraxial opioids in the obstetric setting. Anesth Analg. 2008; 107(3): 956-61[DOI][PubMed]
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