Anesthesiology and Pain Medicine

Published by: Kowsar

Acute Pain Management in Emergency Department, Low Dose Ketamine Versus Morphine, A Randomized Clinical Trial

Babak Mahshidfar 1 , * , Mani Mofidi 1 , Maryam Fattahi 1 , Davood Farsi 1 , Peyman Hafezi Moghadam 1 , Saeed Abbasi 1 and Mahdi Rezai 1
Authors Information
1 Emergency Medicine Management Research Center, Iran University of Medical Sciences, Hazrat Rasoul Akram Complex Emergency Department, Tehran, Iran
Article information
  • Anesthesiology and Pain Medicine: December 2017, 7 (6); e60561
  • Published Online: December 26, 2017
  • Article Type: Research Article
  • Received: October 26, 2016
  • Revised: October 16, 2017
  • Accepted: November 29, 2017
  • DOI: 10.5812/aapm.60561

To Cite: Mahshidfar B, Mofidi M, Fattahi M, Farsi D, Hafezi Moghadam P, et al. Acute Pain Management in Emergency Department, Low Dose Ketamine Versus Morphine, A Randomized Clinical Trial, Anesth Pain Med. 2017 ; 7(6):e60561. doi: 10.5812/aapm.60561.

Abstract
Copyright © 2017, Anesthesiology and Pain Medicine. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Footnote
References
  • 1. Dale J, Bjornsen LP. Assessment of pain in a Norwegian Emergency Department. Scand J Trauma Resusc Emerg Med. 2015;23:86. doi: 10.1186/s13049-015-0166-3. [PubMed: 26514633].
  • 2. McCaig LF, Nawar EW. National Hospital Ambulatory Medical Care Survey: 2004 emergency department summary. Adv Data. 2006;(372):1-29. [PubMed: 16841785].
  • 3. Bhakta HC, Marco CA. Pain management: association with patient satisfaction among emergency department patients. J Emerg Med. 2014;46(4):456-64. doi: 10.1016/j.jemermed.2013.04.018. [PubMed: 23849365].
  • 4. Jennings PA, Cameron P, Bernard S, Walker T, Jolley D, Fitzgerald M, et al. Long-term pain prevalence and health-related quality of life outcomes for patients enrolled in a ketamine versus morphine for prehospital traumatic pain randomised controlled trial. Emerg Med J. 2014;31(10):840-3. doi: 10.1136/emermed-2013-202862. [PubMed: 23851034].
  • 5. Farahmand S, Shiralizadeh S, Talebian MT, Bagheri-Hariri S, Arbab M, Basirghafouri H, et al. Nebulized fentanyl vs intravenous morphine for ED patients with acute limb pain: a randomized clinical trial. Am J Emerg Med. 2014;32(9):1011-5. doi: 10.1016/j.ajem.2014.05.051. [PubMed: 25027194].
  • 6. Miner JR, Moore J, Gray RO, Skinner L, Biros MH. Oral versus intravenous opioid dosing for the initial treatment of acute musculoskeletal pain in the emergency department. Acad Emerg Med. 2008;15(12):1234-40. doi: 10.1111/j.1553-2712.2008.00266.x. [PubMed: 18945240].
  • 7. Birnbaum A, Esses D, Bijur PE, Holden L, Gallagher EJ. Randomized double-blind placebo-controlled trial of two intravenous morphine dosages (0.10 mg/kg and 0.15 mg/kg) in emergency department patients with moderate to severe acute pain. Ann Emerg Med. 2007;49(4):445-53. 453 e1-2. doi: 10.1016/j.annemergmed.2006.06.030. [PubMed: 16978739].
  • 8. Jennings PA, Cameron P, Bernard S, Walker T, Jolley D, Fitzgerald M, et al. Morphine and ketamine is superior to morphine alone for out-of-hospital trauma analgesia: a randomized controlled trial. Ann Emerg Med. 2012;59(6):497-503. doi: 10.1016/j.annemergmed.2011.11.012. [PubMed: 22243959].
  • 9. Bijur PE, Kenny MK, Gallagher EJ. Intravenous morphine at 0.1 mg/kg is not effective for controlling severe acute pain in the majority of patients. Ann Emerg Med. 2005;46(4):362-7. [PubMed: 16187470].
  • 10. Imani F, Faiz HR, Sedaghat M, Hajiashrafi M. Effects of adding ketamine to fentanyl plus acetaminophen on postoperative pain by patient controlled analgesia in abdominal surgery. Anesth Pain Med. 2014;4(1):12162. doi: 10.5812/aapm.12162. [PubMed: 24660145].
  • 11. Miner JR, Gray RO, Bahr J, Patel R, McGill JW. Randomized clinical trial of propofol versus ketamine for procedural sedation in the emergency department. Acad Emerg Med. 2010;17(6):604-11. doi: 10.1111/j.1553-2712.2010.00776.x. [PubMed: 20624140].
  • 12. Riediger C, Haschke M, Bitter C, Fabbro T, Schaeren S, Urwyler A, et al. The analgesic effect of combined treatment with intranasal S-ketamine and intranasal midazolam compared with morphine patient-controlled analgesia in spinal surgery patients: a pilot study. J Pain Res. 2015;8:87-94. doi: 10.2147/JPR.S75928. [PubMed: 25709497].
  • 13. Sin B, Ternas T, Motov SM. The use of subdissociative-dose ketamine for acute pain in the emergency department. Acad Emerg Med. 2015;22(3):251-7. doi: 10.1111/acem.12604. [PubMed: 25716117].
  • 14. Beaudoin FL, Lin C, Guan W, Merchant RC. Low-dose ketamine improves pain relief in patients receiving intravenous opioids for acute pain in the emergency department: results of a randomized, double-blind, clinical trial. Acad Emerg Med. 2014;21(11):1193-202. doi: 10.1111/acem.12510. [PubMed: 25377395].
  • 15. Galinski M, Dolveck F, Combes X, Limoges V, Smail N, Pommier V, et al. Management of severe acute pain in emergency settings: ketamine reduces morphine consumption. Am J Emerg Med. 2007;25(4):385-90. doi: 10.1016/j.ajem.2006.11.016. [PubMed: 17499654].
  • 16. Ahmadi O, Isfahani MN, Feizi A. Comparing low-dose intravenous ketamine-midazolam with intravenous morphine with respect to pain control in patients with closed limb fracture. J Res Med Sci. 2014;19(6):502-8. [PubMed: 25197290].
  • 17. Ahern TL, Herring AA, Anderson ES, Madia VA, Fahimi J, Frazee BW. The first 500: initial experience with widespread use of low-dose ketamine for acute pain management in the ED. Am J Emerg Med. 2015;33(2):197-201. doi: 10.1016/j.ajem.2014.11.010. [PubMed: 25488336].
  • 18. Majidinejad S, Esmailian M, Emadi M. Comparison of Intravenous Ketamine with Morphine in Pain Relief of Long Bones Fractures: a Double Blind Randomized Clinical Trial. Emerg (Tehran). 2014;2(2):77-80. [PubMed: 26495351].
  • 19. Motov S, Rockoff B, Cohen V, Pushkar I, Likourezos A, McKay C, et al. Intravenous Subdissociative-Dose Ketamine Versus Morphine for Analgesia in the Emergency Department: A Randomized Controlled Trial. Ann Emerg Med. 2015;66(3):222-229 e1. doi: 10.1016/j.annemergmed.2015.03.004. [PubMed: 25817884].
  • 20. Miller JP, Schauer SG, Ganem VJ, Bebarta VS. Low-dose ketamine vs morphine for acute pain in the ED: a randomized controlled trial. Am J Emerg Med. 2015;33(3):402-8. doi: 10.1016/j.ajem.2014.12.058. [PubMed: 25624076].
  • 21. Jennings PA, Cameron P, Bernard S. Ketamine as an analgesic in the pre-hospital setting: a systematic review. Acta Anaesthesiol Scand. 2011;55(6):638-43. doi: 10.1111/j.1399-6576.2011.02446.x. [PubMed: 21574967].
  • 22. Losvik OK, Murad MK, Skjerve E, Husum H. Ketamine for prehospital trauma analgesia in a low-resource rural trauma system: a retrospective comparative study of ketamine and opioid analgesia in a ten-year cohort in Iraq. Scand J Trauma Resusc Emerg Med. 2015;23:94. doi: 10.1186/s13049-015-0176-1. [PubMed: 26552691].
  • 23. Lak M, Foroozanmehr MJ, Ramazani MA, Araghizadeh H, Zahedi-Shoolami L. Assessment of ketamine effect as adjuvant to morphine in post- operative pain reduction in donor kidney transplanted. Iran Red Crescent Med J. 2010;12:38-44.
  • 24. Javid MJ, Hajijafari M, Hajipour A, Makarem J, Khazaeipour Z. Evaluation of a low dose ketamine in post tonsillectomy pain relief: a randomized trial comparing intravenous and subcutaneous ketamine in pediatrics. Anesth Pain Med. 2012;2(2):85-9. doi: 10.5812/aapm.4399. [PubMed: 24223344].
  • 25. Hosseini Jahromi SA, Hosseini Valami SM, Hatamian S. Comparison between effect of lidocaine, morphine and ketamine spray on post-tonsillectomy pain in children. Anesth Pain Med. 2012;2(1):17-21. doi: 10.5812/aapm.4092. [PubMed: 24223328].
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments