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Granisetron Versus Dexamethasone in Prophylaxis of Nausea and Vomiting After Laparoscopic Cholecystectomy


Mohammad Ali Ali Hessami 1 , Mitra Yari 2 , *

1 Department of Surgery, Kermanshah University of Medical Sciences, IR Iran

2 Clinical Research Development Center, Imam Reza Hospital, Department of Anesthesiology, Kermanshah University of Medical Sciences,, IR Iran

How to Cite: Hessami M A, Yari M. Granisetron Versus Dexamethasone in Prophylaxis of Nausea and Vomiting After Laparoscopic Cholecystectomy, Anesth Pain Med. Online ahead of Print ; 2(2):81-84. doi: 10.5812/aapm.6945.


Anesthesiology and Pain Medicine: 2 (2); 81-84
Published Online: September 26, 2012
Article Type: Research Article
Received: June 27, 2012
Accepted: July 26, 2012




Background: Post-operative nausea and vomiting (PONV) is one of the common problems after laparoscopic cholecystectomy.

Objectives: The current study aimed to compare Dexamethasone effect with that of Granisetron in prevention of PONV.

Patients and Methods: In the current study 104 patients aged 20-60 with ASA class I or II who were candidates for laparoscopic cholecystectomy were included in the study. Patients were randomly divided into two groups of A and B. 15 minutes before anesthesia induction, in group a patients 3 mg Granisetron and in group B patients 8 mg Dexamethasone was intravenously injected. Then both groups underwent general anesthesia with similar medications. After operation the prevalence of nausea and vomiting was assessed at three time intervals (0-6 hours, 6-12 hours and 12-24 hours after consciousness). SPSS software version 16 was employed to analyze data. T test, chi-square test and Fischer exact test were performed level of significance was P < 0.05.

Results: There was no significant difference between age, gender proportion, weight, height, and body mass index (BMI) of patients in the two groups. In Dexamethasone group, seven patients experienced nausea and three patients had vomiting, and in Granisetron group, five patients experienced nausea and three patients had vomiting after consciousness. Statistical analysis indicated no significant difference between the two groups in this regard.

Conclusions: Intravenous injection of 8 mg Dexamethasone or 3 mg Granisetron before anesthesia induction had similar effects in prophylaxis of nausea and vomiting after laparoscopic cholecystectomy.


Postoperative Nausea and Vomiting Dexamethasone Cholecystectomy

© 2012, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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