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Effects of Clonidine Premedication Upon Postoperative Shivering and Recovery Time in Patients With and Without Opium Addiction After Elective Leg Fracture Surgeries

AUTHORS

Morteza Jabbary Moghaddam 1 , Davood Ommi 1 , Alireza Mirkheshti 1 , * , Ali Dabbagh 1 , Elham Memary 1 , Afsaneh Sadeghi 1 , Mehdi Yaseri 2

1 Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences, alimirkheshti@yahoo.com, Iran

2 Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Iran

How to Cite: Jabbary Moghaddam M, Ommi D, Mirkheshti A, Dabbagh A, Memary E, et al. Effects of Clonidine Premedication Upon Postoperative Shivering and Recovery Time in Patients With and Without Opium Addiction After Elective Leg Fracture Surgeries, Anesth Pain Med. Online ahead of Print ; 2(3):107-110. doi: 10.5812/aapm.7143.

ARTICLE INFORMATION

Anesthesiology and Pain Medicine: 2 (3); 107-110
Published Online: January 1, 2013
Article Type: Research Article
Received: July 7, 2012
Accepted: August 29, 2012
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Abstract

Background: Opium is a highly addictive agent and the most common narcotic often misused in Iran. The pharmacokinetic of anesthetic drugs in patients with opium addiction is one of the great challenges for anesthesiologists. Hemodynamic instability and postoperative side effects are of these challenges which should be managed correctly.

Objectives: In this study we aimed to assess the effects of clonidine upon post anesthesia shivering and recovery time in patients with and without opium addiction after general anesthesia to decrease the subsequent complications related to the shivering and elongation of recovery time.\r\n

Patients and Methods: In a randomized clinical trial, 160 patients candidates for elective leg fracture operations under general anesthesia were studied in four groups of 40 patients: Group 1 (placebo 1) were patients without addiction who got placebo 90 minutes before the operation. Group 2 (placebo 2) were patients with opium addiction which received placebo as group 1. Group 3 (Clonidine 1) patients without addiction who got clonidine 90 minutes before the operation and group 4 (Clonidine 2) who were opium addicted ones which received clonidine as premedication.

Results: None of the patients with and without addiction in clonidine groups had shivering after the operation but in placebo groups shivering was observed and the difference between clonidine and placebo groups was statistically significant (P < 0.01). Recovery time in clonidine groups of patients with and without addiction was less than placebo ones (both P < 0.01) which the magnitude of difference was higher in opium addicted than non-addicted patients (P = 0.04).

Conclusions: Premedication with clonidine in patients with and without opium addiction can be effective to decrease the incidence of shivering and recovery time after operation.

Keywords

Clonidine Opium Behavior Addictive Shivering

© 2013, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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