Propofol is Effective to Depress Fentanyl-Induced Cough during Induction of Anesthesia
Anesthesiology and Pain Medicine: 2 (4); 170-3
March 26, 2013
Article Type: Research Article
October 2, 2012
December 8, 2012
A, Naderi Nabi
S, et al. Propofol is Effective to Depress Fentanyl-Induced Cough during Induction of Anesthesia,
Anesth Pain Med.
Online ahead of Print
Various attempts have been made to reduce the incidence of fentanyl-induced cough during anesthesia induction. We hypothesized that an appropriate dose of propofol might suppress fentanyl-induced cough.
A study had been designed to observe the effects of propofol on a fentanyl-induced cough during anesthesia induction.
Patients and Methods:
We performed a randomized, double-blind study to evaluate the effect of the pre-emptive use of minimal dose intravenous propofol (20 mg) on the incidence of cough caused by a larger bolus of intravenous fentanyl. Group 1 patients were given fentanyl at a dosage of 4 g/kg. Group 2 received 4g/kg fentanyl and 20 mg propofol. The two groups were evaluated in 0, 5 and 10 second intervals following the injection of fentanyl.
Mean age, weight, and, height was 35 10.45, 67.99 10.92, and 165.33 31.84 respectively. The incidence of fentanyl induced cough was 29 (74.4%) in placebo group compared with 10 (25.6%) in the propofol group. There was a significant difference in the incidence and severity of cough between group 1 and 2 (P < 0.0001). This study also showed that propofol could decrease cough incidence in patients who smoke.
Priming dose of propofol (20mg) one minute prior to fentanyl injection was effective in suppressing a fentanyl-induced cough.
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