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Comparison of Fentanyl and Fentanyl Plus Lidocaine on Attenuation of Hemodynamic Responses to Tracheal Intubation in Controlled Hypertensive Patients Undergoing General Anesthesia

AUTHORS

Valiallah Hassani 2 , Gholamreza Movassaghi 3 , Vahid Goodarzi 1 , * , Saeid Safari 1

2 Minimally Invasive Surgery Research Center, Rasoul-Akram Medical Center, Iran University of Medical Sciences (IUMS), Iran

3 Department of Anesthesiology, Hasheminezhad Hospital, Iran University of Medical Sciences (IUMS), Iran

1 Department of Anesthesiology, Rasoul-Akram Medical Center, Iran University of Medical Sciences (IUMS), vahid_md_58@yahoo.com, Iran

How to Cite: Hassani V, Movassaghi G, Goodarzi V, Safari S . Comparison of Fentanyl and Fentanyl Plus Lidocaine on Attenuation of Hemodynamic Responses to Tracheal Intubation in Controlled Hypertensive Patients Undergoing General Anesthesia, Anesth Pain Med. Online ahead of Print ; 2(3):115-118. doi: 10.5812/aapm.6442.

ARTICLE INFORMATION

Anesthesiology and Pain Medicine: 2 (3); 115-118
Published Online: January 1, 2013
Article Type: Research Article
Received: May 21, 2012
Accepted: August 5, 2012
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Abstract

Background: Induction of anesthesia and endotracheal intubation often creates a period of hemodynamic instability in hypertensive patients. Endotracheal intubation of the trachea stimulates laryngeal and tracheal sensory receptors, resulting in a marked increase in the elaboration of sympathetic amines.

Objectives: This trial aimed to evaluate and compare the efficacy of fentanyl and fentanyl plus lidocaine in attenuating the hemodynamic responses to laryngoscopy and endotracheal intubation in hypertensive patients.

Patients and Methods: We conducted a prospective, randomized, double-blind trial in 37 patients with hypertension in the Rasoul-Akram Hospital, Tehran, Iran, from March to December 2011. The patients were randomly divided into two groups (fentanyl group and fentanyl plus lidocaine group). The fentanyl group received 2 mcg/kg and the fentanyl plus lidocaine group received 1.5mg lidocaine and 2mcg/kg fentanyl. Hemodynamic variables were recorded at baseline, after giving inductive anesthetic agents, and 1, 3 and 5 minutes after performing endotracheal intubation.

Results: We evaluated 37 patients including 15 males (40.54%) and 22 females (59.46%), with a mean age of 56.08 10.85 years. There were no significant differences between the two groups regarding; heart rate, systolic blood pressure and diastolic blood pressure before induction, 3 minutes before intubation and 1, 3 and 5 minutes after intubation.

Conclusions: Fentanyl and fentanyl plus lidocaine effectively decreased the hemodynamic response to tracheal intubation, however, neither fentanyl nor fentanyl plus lidocaine, could inhibit all hemodynamic responses, moreover fentanyl plus lidocaine was not more effective than fentanyl alone.

Keywords

Hemodynamics Lidocaine Fentanyl Intubation Intratracheal Drug Stability

© 2013, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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