Anesthesiology and Pain Medicine

Published by: Kowsar

Comparing the Effect of Clonidine and Dexmedetomidine on Intraoperative Bleeding in Spine Surgery

Farahzad Janatmakan 1 , Sholeh Nesioonpour 1 , Fatemeh Javaherforoosh Zadeh 2 , Alireza Teimouri 3 and Mahshid Vaziri 1 , *
Authors Information
1 Department of Anesthesia, Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Department of Anesthesia, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Department of Neurosurgery, Tehran Medical Science Branch, Islamic Azad University Tehran, Iran
Article information
  • Anesthesiology and Pain Medicine: 9 (1); e83967
  • Published Online: February 24, 2019
  • Article Type: Research Article
  • Received: September 5, 2018
  • Revised: November 14, 2018
  • Accepted: November 21, 2018
  • DOI: 10.5812/aapm.83967

To Cite: Janatmakan F, Nesioonpour S, Javaherforoosh Zadeh F, Teimouri A, Vaziri M. Comparing the Effect of Clonidine and Dexmedetomidine on Intraoperative Bleeding in Spine Surgery, Anesth Pain Med. Online ahead of Print ; 9(1):e83967. doi: 10.5812/aapm.83967.

Copyright © 2019, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
  • 1. Cole JW, Murray DJ, Snider RJ, Bassett GS, Bridwell KH, Lenke LG. Aprotinin reduces blood loss during spinal surgery in children. Spine (Phila Pa 1976). 2003;28(21):2482-5. doi: 10.1097/01.BRS.0000090835.45437.7F. [PubMed: 14595168].
  • 2. Szpalski M, Gunzburg R, Sztern B. An overview of blood-sparing techniques used in spine surgery during the perioperative period. Eur Spine J. 2004;13 Suppl 1:S18-27. doi: 10.1007/s00586-004-0752-y. [PubMed: 15480823]. [PubMed Central: PMC3592191].
  • 3. Jabalameli M, Hashemi M, Soltani H, Hashemi SJ. Oral clonidine premedication decreases intraoperative bleeding in patients undergoing endoscopic sinus surgery. J Res Med Sci. 2005;1:25-30.
  • 4. Ayoglu H, Yapakci O, Ugur MB, Uzun L, Altunkaya H, Ozer Y, et al. Effectiveness of dexmedetomidine in reducing bleeding during septoplasty and tympanoplasty operations. J Clin Anesth. 2008;20(6):437-41. doi: 10.1016/j.jclinane.2008.04.008. [PubMed: 18929284].
  • 5. Wijeysundera DN, Naik JS, Beattie WS. Alpha-2 adrenergic agonists to prevent perioperative cardiovascular complications: A meta-analysis. Am J Med. 2003;114(9):742-52. [PubMed: 12829201].
  • 6. Javaherforooshzadeh F, Monajemzadeh SA, Soltanzadeh M, Janatmakan F, Salari A, Saeed H. A comparative study of the amount of bleeding and hemodynamic changes between dexmedetomidine infusion and remifentanil infusion for controlled hypotensive anesthesia in lumbar discopathy surgery: A double-blind, randomized, clinical trial. Anesth Pain Med. 2018;8(2). e66959. doi: 10.5812/aapm.66959. [PubMed: 30009153]. [PubMed Central: PMC6035495].
  • 7. Somayaji A, Raveendra U. Effect of dexmedetomidine on blood loss and quality of surgical field in functional endoscopic sinus surgery: A double blinded prospective controlled study. Karnataka Anaesth J. 2016;2(3):90-8. doi: 10.4103/kaj.kaj_14_17.
  • 8. Rahimzadeh P, Faiz SH, Alimian M, Mohammadian Erdi A. Remifentanil versus dexmedtomidine for posterior spinal fusion surgery. Med J Islam Repub Iran. 2015;29:215. [PubMed: 26478873]. [PubMed Central: PMC4606949].
  • 9. Singh A. A study to evaluate the effectiveness of clonidine vs atenolol in providing optimal surgical field in nasal surgeries under general anaesthesia. J Anesth Clin Res. 2014;5(3). doi: 10.4172/2155-6148.1000396.
  • 10. Taghipour Anvari Z, Afshar-Fereydouniyan N, Imani F, Sakhaei M, Alijani B, Mohseni M. Effect of clonidine premedication on blood loss in spine surgery. Anesth Pain Med. 2012;1(4):252-6. doi: 10.5812/aapm.2197. [PubMed: 24904810]. [PubMed Central: PMC4018704].
  • 11. Ibraheim OA, Abdulmonem A, Baaj J, Zahrani TA, Arlet V. Esmolol versus dexmedetomidine in scoliosis surgery: Study on intraoperative blood loss and hemodynamic changes. Middle East J Anaesthesiol. 2013;22(1):27-33. [PubMed: 23833847].
  • 12. Ebneshahidi A, Mohseni M. Premedication with oral clonidine decreases intraoperative bleeding and provides hemodynamic stability in cesarean section. Anesth Pain Med. 2011;1(1):30-3. doi: 10.5812/kowsar.22287523.1337. [PubMed: 25729653]. [PubMed Central: PMC4335754].
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments