Anesthesiology and Pain Medicine

Published by: Kowsar

Comparison of Intranasal Dexmedetomidine and Oral Ketamine Versus Intranasal Midazolam Premedication for Children Undergoing Dental Rehabilitation

Mohamed E Oriby 1 , 2 , *
Author Information
1 Department of Anesthesia and Surgical Intensive Care, Tanta University, Tanta, Egypt
2 Anesthesia Department, Magrabi Center, Doha, Qatar
Article information
  • Anesthesiology and Pain Medicine: 9 (1); e85227
  • Published Online: February 6, 2019
  • Article Type: Research Article
  • Received: October 10, 2018
  • Revised: December 15, 2018
  • Accepted: December 17, 2018
  • DOI: 10.5812/aapm.85227

To Cite: Oriby M E. Comparison of Intranasal Dexmedetomidine and Oral Ketamine Versus Intranasal Midazolam Premedication for Children Undergoing Dental Rehabilitation, Anesth Pain Med. Online ahead of Print ; 9(1):e85227. doi: 10.5812/aapm.85227.

Abstract
Copyright © 2019, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Footnotes
References
  • 1. Creedon LR, Dock M. Pharmacological management of patient behavior. In: McDonald RE, Avery DR, editors. Dentistry for the children and adolescent. 8th ed. China: Louis: Mosby CV; 2004. p. 285-311.
  • 2. Davidson A, McKenzie I. Distress at induction: Prevention and consequences. Curr Opin Anaesthesiol. 2011;24(3):301-6. doi: 10.1097/ACO.0b013e3283466b27. [PubMed: 21494130].
  • 3. Kain ZN, Caldwell-Andrews AA, Maranets I, McClain B, Gaal D, Mayes LC, et al. Preoperative anxiety and emergence delirium and postoperative maladaptive behaviors. Anesth Analg. 2004;99(6):1648-54. table of contents. doi: 10.1213/01.ANE.0000136471.36680.97. [PubMed: 15562048].
  • 4. Calipel S, Lucas-Polomeni MM, Wodey E, Ecoffey C. Premedication in children: Hypnosis versus midazolam. Paediatr Anaesth. 2005;15(4):275-81. doi: 10.1111/j.1460-9592.2004.01514.x. [PubMed: 15787917].
  • 5. Kain ZN, Hofstadter MB, Mayes LC, Krivutza DM, Alexander G, Wang SM, et al. Midazolam: Effects on amnesia and anxiety in children. Anesthesiology. 2000;93(3):676-84. [PubMed: 10969300].
  • 6. Yuen VM, Irwin MG, Hui TW, Yuen MK, Lee LH. A double-blind, crossover assessment of the sedative and analgesic effects of intranasal dexmedetomidine. Anesth Analg. 2007;105(2):374-80. doi: 10.1213/01.ane.0000269488.06546.7c. [PubMed: 17646493].
  • 7. Cortinas M, Oya B, Caparros P, Cano G, Ibarra M, Martinez L. [Oral ketamine-midazolam premedication of uncooperative patients in major outpatient surgery]. Rev Esp Anestesiol Reanim. 2010;57(8):479-85. Spanish. doi: 10.1016/S0034-9356(10)70708-8. [PubMed: 21033454].
  • 8. Peltoniemi MA, Hagelberg NM, Olkkola KT, Saari TI. Ketamine: A review of clinical pharmacokinetics and pharmacodynamics in anesthesia and pain therapy. Clin Pharmacokinet. 2016;55(9):1059-77. doi: 10.1007/s40262-016-0383-6. [PubMed: 27028535].
  • 9. Levanen J, Makela ML, Scheinin H. Dexmedetomidine premedication attenuates ketamine-induced cardiostimulatory effects and postanesthetic delirium. Anesthesiology. 1995;82(5):1117-25. doi: 10.1097/00000542-199505000-00005. [PubMed: 7741286].
  • 10. Almenrader N, Passariello M, Coccetti B, Haiberger R, Pietropaoli P. Premedication in children: A comparison of oral midazolam and oral clonidine. Paediatr Anaesth. 2007;17(12):1143-9. doi: 10.1111/j.1460-9592.2007.02332.x. [PubMed: 17263737].
  • 11. Feng JF, Wang XX, Lu YY, Pang DG, Peng W, Mo JL. Effects of dexmedetomidine versus midazolam for premedication in paediatric anaesthesia with sevoflurane: A meta-analysis. J Int Med Res. 2017;45(3):912-23. doi: 10.1177/0300060517704595. [PubMed: 28425829]. [PubMed Central: PMC5536403].
  • 12. Jannu V, Mane RS, Dhorigol MG, Sanikop CS. A comparison of oral midazolam and oral dexmedetomidine as premedication in pediatric anesthesia. Saudi J Anaesth. 2016;10(4):390-4. doi: 10.4103/1658-354X.177333. [PubMed: 27833480]. [PubMed Central: PMC5044721].
  • 13. Talon MD, Woodson LC, Sherwood ER, Aarsland A, McRae L, Benham T. Intranasal dexmedetomidine premedication is comparable with midazolam in burn children undergoing reconstructive surgery. J Burn Care Res. 2009;30(4):599-605. doi: 10.1097/BCR.0b013e3181abff90. [PubMed: 19506498].
  • 14. Lonnqvist PA, Habre W. Midazolam as premedication: Is the emperor naked or just half-dressed? Paediatr Anaesth. 2005;15(4):263-5. doi: 10.1111/j.1460-9592.2005.01600.x. [PubMed: 15787915].
  • 15. Kanegaye JT, Favela JL, Acosta M, Bank DE. High-dose rectal midazolam for pediatric procedures: A randomized trial of sedative efficacy and agitation. Pediatr Emerg Care. 2003;19(5):329-36. doi: 10.1097/01.pec.0000092578.40174.85. [PubMed: 14578832].
  • 16. Qiao H, Xie Z, Jia J. Pediatric premedication: A double-blind randomized trial of dexmedetomidine or ketamine alone versus a combination of dexmedetomidine and ketamine. BMC Anesthesiol. 2017;17(1):158. doi: 10.1186/s12871-017-0454-8. [PubMed: 29187151]. [PubMed Central: PMC5708105].
  • 17. Yuen VM, Hui TW, Irwin MG, Yuen MK. A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: A double-blinded randomized controlled trial. Anesth Analg. 2008;106(6):1715-21. doi: 10.1213/ane.0b013e31816c8929. [PubMed: 18499600].
  • 18. Bergendahl H, Lonnqvist PA, Eksborg S. Clonidine: An alternative to benzodiazepines for premedication in children. Curr Opin Anaesthesiol. 2005;18(6):608-13. doi: 10.1097/01.aco.0000191891.44314.36. [PubMed: 16534300].
  • 19. Bergendahl H, Lonnqvist PA, Eksborg S. Clonidine in paediatric anaesthesia: Review of the literature and comparison with benzodiazepines for premedication. Acta Anaesthesiol Scand. 2006;50(2):135-43. doi: 10.1111/j.1399-6576.2006.00940.x. [PubMed: 16430532].
  • 20. Nelson LE, Lu J, Guo T, Saper CB, Franks NP, Maze M. The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects. Anesthesiology. 2003;98(2):428-36. [PubMed: 12552203].
  • 21. Jia JE, Chen JY, Hu X, Li WX. A randomised study of intranasal dexmedetomidine and oral ketamine for premedication in children. Anaesthesia. 2013;68(9):944-9. doi: 10.1111/anae.12312. [PubMed: 23848405].
  • 22. Zanaty OM, El Metainy SA. A comparative evaluation of nebulized dexmedetomidine, nebulized ketamine, and their combination as premedication for outpatient pediatric dental surgery. Anesth Analg. 2015;121(1):167-71. doi: 10.1213/ANE.0000000000000728. [PubMed: 25822924].
  • 23. Behrle N, Birisci E, Anderson J, Schroeder S, Dalabih A. Intranasal dexmedetomidine as a sedative for pediatric procedural sedation. J Pediatr Pharmacol Ther. 2017;22(1):4-8. doi: 10.5863/1551-6776-22.1.4. [PubMed: 28337075]. [PubMed Central: PMC5341530].
  • 24. Faritus SZ, Khazaee-Koohpar M, Ziyaeifard M, Mehrabanian MJ. Oral dexmedetomidine versus midazolam as anesthetic premedication in children undergoing congenital heart surgery. Anesth Pain Med. 2015;5(3). e25032. doi: 10.5812/aapm.5(3)2015.25032. [PubMed: 26161325]. [PubMed Central: PMC4493729].
  • 25. Sheta SA, Al-Sarheed MA, Abdelhalim AA. Intranasal dexmedetomidine vs midazolam for premedication in children undergoing complete dental rehabilitation: A double-blinded randomized controlled trial. Paediatr Anaesth. 2014;24(2):181-9. doi: 10.1111/pan.12287. [PubMed: 24237879].
  • 26. Akin A, Bayram A, Esmaoglu A, Tosun Z, Aksu R, Altuntas R, et al. Dexmedetomidine vs midazolam for premedication of pediatric patients undergoing anesthesia. Paediatr Anaesth. 2012;22(9):871-6. doi: 10.1111/j.1460-9592.2012.03802.x. [PubMed: 22268591].
  • 27. Imani F, Rahimzadeh P, Faiz HR, Nowruzina S, Shakeri A, Ghahremani M. Comparison of the post-caesarean analgesic effect of adding dexmedetomidine to paracetamol and ketorolac: A randomized clinical trial. Anesth Pain Med. 2018;8(5). e85311. doi: 10.5812/aapm.85311. [PubMed: 30538943]. [PubMed Central: PMC6252045].
  • 28. Blaine Easley R, Brady KM, Tobias JD. Dexmedetomidine for the treatment of postanesthesia shivering in children. Paediatr Anaesth. 2007;17(4):341-6. doi: 10.1111/j.1460-9592.2006.02100.x. [PubMed: 17359402].
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .
Readers' Comments