Anesthesiology and Pain Medicine

Published by: Kowsar

Comparison of Intravenous Dexmedetomidine-Propofol Versus Ketofol for Sedation During Awake Fiberoptic Intubation: A Prospective, Randomized Study

Mona Blough El Mourad 1 , * , Mona Raafat Elghamry 1 , Radwa Fathy Mansour 1 and Mohamed Elsayed Afandy 1
Authors Information
1 Department of Anesthesia and Surgical Intensive Care, Faculty of Medicine, Tanta University, Tanta, Egypt
Article information
  • Anesthesiology and Pain Medicine: 9 (1); e86442
  • Published Online: February 26, 2019
  • Article Type: Research Article
  • Received: November 16, 2018
  • Revised: February 6, 2019
  • Accepted: February 10, 2019
  • DOI: 10.5812/aapm.86442

To Cite: El Mourad M B, Elghamry M R, Mansour R F, Afandy M E. Comparison of Intravenous Dexmedetomidine-Propofol Versus Ketofol for Sedation During Awake Fiberoptic Intubation: A Prospective, Randomized Study, Anesth Pain Med. Online ahead of Print ; 9(1):e86442. doi: 10.5812/aapm.86442.

Abstract
Copyright © 2019, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Footnotes
References
  • 1. Lee SY, Hahm TS, Jin HS. Endotracheal intubation in a patient with an almost complete obstruction of the glottis due to a movable supraglottic tumor: A case report. Korean J Anesthesiol. 2009;56(1):87-91. doi: 10.4097/kjae.2009.56.1.87. [PubMed: 30625701].
  • 2. Lallo A, Billard V, Bourgain JL. A comparison of propofol and remifentanil target-controlled infusions to facilitate fiberoptic nasotracheal intubation. Anesth Analg. 2009;108(3):852-7. doi: 10.1213/ane.0b013e318184eb31. [PubMed: 19224793].
  • 3. Liu HH, Zhou T, Wei JQ, Ma WH. Comparison between remifentanil and dexmedetomidine for sedation during modified awake fiberoptic intubation. Exp Ther Med. 2015;9(4):1259-64. doi: 10.3892/etm.2015.2288. [PubMed: 25780419]. [PubMed Central: PMC4353735].
  • 4. Avitsian R, Manlapaz M, Doyle JD. Dexmedetomidine as a sedative for awake fiberoptic intubation. J Cli Anesth. 2007;17:19-24.
  • 5. Abdalla MW, El Shal SM, El Sombaty AI, Abdalla NM, Zeedan RB. Propofol dexmedetomidine versus propofol ketamine for anesthesia of endoscopic retrograde cholangiopancreatography (ERCP) (A randomized comparative study). Egypt J Anaesth. 2015;31(2):97-105. doi: 10.1016/j.egja.2014.12.008.
  • 6. Himmelseher S, Durieux ME. Ketamine for perioperative pain management. Anesthesiology. 2005;102(1):211-20. [PubMed: 15618805].
  • 7. Shams T, El-Masry R. Ketofol-Dexmedetomidine combination in ECT: A punch for depression and agitation. Indian J Anaesth. 2014;58(3):275-80. doi: 10.4103/0019-5049.135037. [PubMed: 25024469]. [PubMed Central: PMC4090992].
  • 8. Rapeport DA, Martyr JW, Wang LP. The use of "ketofol" (ketamine-propofol admixture) infusion in conjunction with regional anaesthesia. Anaesth Intensive Care. 2009;37(1):121-3. [PubMed: 19157358].
  • 9. Ryu JH, Lee SW, Lee JH, Lee EH, Do SH, Kim CS. Randomized double-blind study of remifentanil and dexmedetomidine for flexible bronchoscopy. Br J Anaesth. 2012;108(3):503-11. doi: 10.1093/bja/aer400. [PubMed: 22174346].
  • 10. Ayoglu H, Altunkaya H, Ozer Y, Yapakci O, Ozkocak I, Oz O, et al. Dexmedetomidine sedation during cataract surgery under regional anaesthesia. Br J Anaesth. 2007;99(3):448. doi: 10.1093/bja/aem226. [PubMed: 17702833].
  • 11. Bergese SD, Candiotti KA, Bokesch PM, Zura A, Wisemandle W, Bekker AY, et al. A Phase IIIb, randomized, double-blind, placebo-controlled, multicenter study evaluating the safety and efficacy of dexmedetomidine for sedation during awake fiberoptic intubation. Am J Ther. 2010;17(6):586-95. doi: 10.1097/MJT.0b013e3181d69072. [PubMed: 20535016].
  • 12. Yagan O, Karakahya RH, Tas N, Kucuk A. Comparison of dexmedetomidine versus ketamine-propofol combination for sedation in cataract surgery. Turk J Anaesthesiol Reanim. 2015;43(2):84-90. doi: 10.5152/TJAR.2014.45220. [PubMed: 27366473]. [PubMed Central: PMC4917163].
  • 13. Sruthi S, Mandal B, Rohit MK, Puri GD. Dexmedetomidine versus ketofol sedation for outpatient diagnostic transesophageal echocardiography: A randomized controlled study. Ann Card Anaesth. 2018;21(2):143-50. doi: 10.4103/aca.ACA_171_17. [PubMed: 29652275]. [PubMed Central: PMC5914214].
  • 14. Hassan HIEA. Dexmedetomidine versus ketofol for moderate sedation in endoscopic retrograde cholangiopancreatography (ERCP) comparative study. Egypt J Anaesth. 2015;31(1):15-21. doi: 10.1016/j.egja.2014.11.002.
  • 15. Boyd BC, Sutter SJ. Dexmedetomidine sedation for awake fiberoptic intubation of patients with difficult airways due to severe odontogenic cervicofacial infections. J Oral Maxillofac Surg. 2011;69(6):1608-12. doi: 10.1016/j.joms.2010.11.004. [PubMed: 21392875].
  • 16. Daabiss M, Elsherbiny M, Al Otaibi R. Assessment of different concentrations of ketofol in procedural operations. Saudi J Anaesth. 2009;3(1):15. doi: 10.4103/1658-354x.51829.
  • 17. Canpolat DG, Yildirim MD, Kutuk N, Dogruel F, Ocak H, Aksu R, et al. Comparison of ketamine-propofol and ketamine-dexmedetomidine combinations in children for sedation during tooth extraction. J Pak Med Assoc. 2017;67(5):693-7. [PubMed: 28507353].
  • 18. Willman EV, Andolfatto G. A prospective evaluation of "ketofol" (ketamine/propofol combination) for procedural sedation and analgesia in the emergency department. Ann Emerg Med. 2007;49(1):23-30. doi: 10.1016/j.annemergmed.2006.08.002. [PubMed: 17059854].
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