Effects of Single-Dose Pregabalin on Postoperative Pain in Dacryocystorhinostomy Surgery

AUTHORS

Mahzad Alimian 1 , * , Farnad Imani 1 , Valiollah Hassani 1 , Poupak Rahimzadeh 1 , Mahshid Sharifian 1 , Saeid Safari 1

1 Department of Anesthesiology, Rasoul-Akram Medical Center, Tehran University of Medical Sciences (TUMS), [email protected], IR Iran

How to Cite: Alimian M, Imani F, Hassani V, Rahimzadeh P, Sharifian M, et al. Effects of Single-Dose Pregabalin on Postoperative Pain in Dacryocystorhinostomy Surgery, Anesth Pain Med. Online ahead of Print ; 2(2):72-76. doi: 10.5812/aapm.4301.

ARTICLE INFORMATION

Anesthesiology and Pain Medicine: 2 (2); 72-76
Published Online: September 26, 2012
Article Type: Research Article
Received: February 2, 2012
Accepted: May 1, 2012
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Abstract

Background: Postoperative pain of dacryocystorhinostomy (DCA) surgery is one of the serious issues to be considered. Administrating opioids to relieve postoperative pain and facing their increasing side effects in eye surgeries, make the use of non-opioid drugs inevitable.

Objectives: The present study examined the efficacy of pregabalin in alleviating the postoperative pain of DCA surgery.

Patients and Methods: The present study has been carried out as a double-blind, randomized clinical trial on the patient candidates for DCR. The patients were randomly divided in to two groups of pregabalin and placebo. Patients in pregabalin group received 300 mg of pregabalin, an hour before the operation in the morning of the surgery. Pain intensity on visual analog scale (VAS) was recorded until 24 hours after the operation; also the rate of administrated opioids and nausea/vomiting frequency were recorded during the first 24-hour period after the operation and the resultsof the two groups were compared.

Results: Postoperative pain intensity in the pregabalin group at the time of recovery was significantly lower than that of the placebo group (P = 0.001) until 24 hours after the surgery. In the pregabalin group 17.5% of the patients received opioids while in the placebo group the figure was 52.5% (P = 0.001). Nausea frequency was also higher in the placebo group than the pregabalin group (P = 0.003).

Conclusions: A single 300 mg dose of pregabalin, an hour before DCA can effectively reduce pain intensity and also reduce opioid dose and nausea/vomiting.

Keywords

Pregabalin Pain, Postoperative Dacryocystorhinostomy

© 2012, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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